[1]余静,史颖颖,卢祖能,等.丁苯酞通过调控Nrf2通路来改善脑小血管病的认知功能障碍[J].卒中与神经疾病杂志,2024,31(06):537-540.[doi:10.3969/j.issn.1007-0478.2024.06.005]
　Yu Jing*,Shi Yingying,Lu Zuneng,et al.DL-3-N-butylphthalide can improve cognitive impairment in cerebral small vascular disease by regulating Nrf2 pathway[J].Stroke and Nervous Diseases,2024,31(06):537-540.[doi:10.3969/j.issn.1007-0478.2024.06.005]
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丁苯酞通过调控Nrf2通路来改善脑小血管病的认知功能障碍()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第31卷
期数:
2024年06期
页码:
537-540
栏目:
论著
出版日期:
2024-12-20

文章信息/Info

Title:
DL-3-N-butylphthalide can improve cognitive impairment in cerebral small vascular disease by regulating Nrf2 pathway
文章编号:
1007-0478(2024)06-0537-04
作者:
余静; 史颖颖; 卢祖能; 尹皓
430300 武汉市黄陂区人民医院检验科(余静),神经内科[尹皓(通信作者)]; 江汉大学医学部(史颖颖); 武汉大学人民医院神经内科(卢祖能)
Author(s):
Yu Jing*;  Shi Yingying;  Lu Zuneng;  et al.
*Department of Medical Laboratory, Huangpi District People's Hospital Affiliated to Jianghan University or Wuhan Huangpi District People's Hospital, Wuhan 430300
关键词:
丁苯酞 Nrf2 脑小血管病 认知功能障碍
Keywords:
DL-3-N-butylphthalein Nrf2 Cerebral small vascular disease Cognitive impairment
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2024.06.005
文献标志码:
A
摘要:
目的 探索丁苯酞通过调控核因子e2(Nuclear factor erythroid-2,NF-E2)相关的转录因子(Related factor 2,Nrf2)信号通路来改善脑小血管病的认知功能障碍。方法 成功建立脑小血管病(Cerebral small vascular disease,CSVD)SD大鼠模型,将成功建立的脑小血管病大鼠模型随机分为空白组、模型组及治疗组,比较3组大鼠水迷宫实验行为学表现,检测3组大鼠脑组织Nrf2蛋白的水平。结果 模型组大鼠在水迷宫实验中穿越平台次数明显减少(P<0.05),治疗组能明显改善其穿越平台次数(P<0.05)。Western blot显示模型组Nrf2蛋白的水平明显低于空白组(P<0.05),而治疗组明显得到改善(P<0.05)。结论 丁苯酞通过调控Nrf2信号通路来改善脑小血管病大鼠模型的认知功能障碍。
Abstract:
ObjectiveTo explore the effect of butylphthalein on cognitive impairment in cerebral small vascular disease by regulating Nrf2 signaling pathway that is related to nuclear factor erythroid-2(NF-E2).Methods Mouse models of cerebral small vascular disease were established successfully and randomly divided into blank group, model group and treatment group. The behavior data of water maze experiment were compared among the three groups. The levels of Nrf2 protein in brain tissue of three groups of mice were detected.Results In the water maze experiment, the times of crossing the platform were significantly reduced in the model group(P<0.05), and the times of crossing the platform was significantly improved in the treatment group(P<0.05)Western blot detection of Nrf2 protein changes in the brain tissues of the three groups of mice and indicated that Nrf2 in the model group was significantly lower than that in the blank group(P<0.05), while Nrf2 in the experimental group was significantly improved(P<0.05).Conclusion DL-3-N-butylphthalein can improve cognitive impairment in small cerebral vascular disease by regulating Nrf2 signaling pathway.

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备注/Memo

备注/Memo:
基金项目:武汉市中医药科研项目(WZ24Z14)
更新日期/Last Update: 2024-12-20