[1]张晶晶,苏静,郑志勇,等.帕金森病合并快速眼动睡眠行为障碍患者发生MCI的危险因素及列线图构建[J].卒中与神经疾病杂志,2024,31(06):563-567.[doi:10.3969/j.issn.1007-0478.2024.06.010]
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帕金森病合并快速眼动睡眠行为障碍患者发生MCI的危险因素及列线图构建()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第31卷
期数:
2024年06期
页码:
563-567
栏目:
论著
出版日期:
2024-12-20

文章信息/Info

文章编号:
1007-0478(2024)06-0563-05
作者:
张晶晶苏静郑志勇刘艳霞
453100 河南省新乡医学院第一附属医院神经内科五病区[张晶晶 苏静 郑志勇 刘艳霞(通信作者)]
关键词:
帕金森病 快速眼动睡眠行为障碍 认知功能 列线图 轻度认知功能障碍
分类号:
R742.5
DOI:
10.3969/j.issn.1007-0478.2024.06.010
文献标志码:
A
摘要:
目的 建立帕金森病合并快速眼动睡眠行为障碍(Parkinson's disease REM sleep behavior disorder,PD-RBD)患者轻度认知功能障碍(Mild cognitive impairment,MCI)的预测模型并进行初步验证。方法 回顾性分析新乡医学院第一附属医院2018年12月-2022年12月收治的PD-RBD患者235例,根据是否合并MCI将患者分为MCI组(68例)和非MCI组(167例); 收集2组患者的人口学特征、病程、Hoehn-Yahr分期(H-Y分期)、震颤为主/姿势不稳和步态困难(Tremor dominant/postural instability and gait difficulty,TD/PIGD)分型、14项汉密尔顿焦虑量表(Hamilton anxiety scale-14 item,HAMA-14)评分、17项汉密尔顿抑郁量表(Hamilton depression scale-17 item,HAMD-17)评分等指标; 采用Logistics回归筛选危险因素,并绘制列线图模型,受试者工作特征(Receiver operating characteristic,ROC)曲线和校准曲线评价模型的区分度和校准度,并进行内部验证。结果 单因素和多因素分析显示,性别、PD病程、H-Y分级、TD/PIGD分型、HAMD-17评分、HAMA-14评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、39项PD问卷(Parkinson's disease questionnaire-39 items,PDQ-39)评分均是PD-RBD患者发生MCI的最终预测因子; 上述模型预测的曲线下面积为0.879(95%CI=0.83~0.928,P<0.001),同时具有良好的校准度(H-L χ2=4.368,P=0.431)。结论 本研究建立的预测模型有助于评估PD-RBD患者发生MCI的风险,临床价值较好。

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备注/Memo

备注/Memo:
基金项目:河南省医学科技攻关计划联合共建项目(2018020361); 新乡医学院第一附属医院青年培育基金项目(QN-2019-B08)
更新日期/Last Update: 2024-12-20