[1]曾雅清,戚妹,王琴,等.邻苯二甲酸盐暴露与罹患脑卒中风险的相关性:基于NHANES的横断面研究[J].卒中与神经疾病杂志,2025,32(02):190-196.[doi:10.3969/j.issn.1007-0478.2025.02.014]
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邻苯二甲酸盐暴露与罹患脑卒中风险的相关性:基于NHANES的横断面研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第32卷
期数:
2025年02期
页码:
190-196
栏目:
论著
出版日期:
2025-04-20

文章信息/Info

文章编号:
1007-0478(2025)02-0190-07
作者:
曾雅清; 戚妹; 王琴; 何建丽
528415 广东省中山市小榄人民医院神经内科(中山市第五人民医院)(曾雅清),神经内科一区(戚妹 王琴 何建丽)
关键词:
环境暴露 邻苯二甲酸盐 脑卒中 横断面研究 美国国家健康与营养调查
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2025.02.014
文献标志码:
A
摘要:
目的 采用横断面分析方法探讨邻苯二甲酸盐暴露与脑卒中患病率的相关性。方法 基于美国国家健康和营养调查数据库2017～2020年调查数据,选取1335例参与者作为研究对象,根据疾病状况问卷判断脑卒中患者,收集单乙基苯二酸酯(Mono-ethyl phthalate,MEP)、单正丁基苯二酸酯(Mono-n-butyl phthalate,MnBP)、单苯甲基苯二酸酯(Mono-benzyl phthalate,MBzP)和单(3-羧基丙基)苯二酸酯[Mono-(3-carboxypropyl)phthalate,MCPP]等共计十类邻苯二甲酸盐尿液代谢物水平; 采用多因素logistic回归分析探讨邻苯二甲酸盐暴露与脑卒中患病的相关性,构建限制性立方样条模型以明确剂量依赖关系。结果 最终纳入脑卒中患者67例和对照组1268例,脑卒中患者MEP,MnBP,MBzP和MCPP尿液代谢物水平均高于对照组(P<0.05); 多因素logistic回归表明,调整年龄、种族、出生地、受教育程度、吸烟史、高血压病史、糖尿病史等协变量后MEP(OR=1.001,95% CI=1.001～1.002),MnBP(OR=1.020,95% CI=1.006～1.034),MBzP(OR=1.046,95% CI=1.016～1.076),MCPP(OR=1.039,95% CI=1.003～1.076)代谢物水平增高与脑卒中患病风险升高独立相关(P<0.05); 定量分析显示,MEP,MnBP和MBzP水平与脑卒中患病风险的剂量-反应关系具有明显差异(P<0.05),且MnBP和MBzP水平与脑卒中患病呈正向线性关系(非线性P=0.056、0.053)。结论 尿液中MEP,MnBP,MBzP和MCPP的邻苯二甲酸盐代谢物水平与脑卒中患病风险显著相关,邻苯二甲酸盐暴露可能是脑卒中的潜在危险因素。

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备注/Memo

备注/Memo:
基金项目:中山市医学科研项目(2019A020198)
更新日期/Last Update: 2025-04-20