[1]李新玲 黄怀宇 朱连海等. 急性幕上性脑出血患者脑水肿体积与高迁移率族蛋白B1的关系[J].卒中与神经疾病杂志,2016,23(05):326-328.[doi:10.3969/j.issn.1007-0478.2016.05.005]
 Li Xinling,Huang Huaiyu,Zhu Lianhai,et al. The preliminary study of association between serum HMGB1 levels and perihematoma edema volume after supratentorial intracerebral hemorrhage[J].Stroke and Nervous Diseases,2016,23(05):326-328.[doi:10.3969/j.issn.1007-0478.2016.05.005]
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年05期
页码:
326-328
栏目:
论 著
出版日期:
2016-10-26

文章信息/Info

Title:
 The preliminary study of association between serum HMGB1 levels and perihematoma edema volume after supratentorial intracerebral hemorrhage
作者:
 李新玲 黄怀宇 朱连海等
 226001 江苏南通大学第二附属医院神经内科[李新玲 黄怀宇 朱连海 丁莉(通信作者)陆珍辉],神经外科(汪志峰)
Author(s):
 Li XinlingHuang HuaiyuZhu Lianhaiet al. 
 Neurology Department,The Second Affiliated Hospital of Nantong Universty,Jiangsu 226001
关键词:
 高迁移率族蛋白B1 脑出血 脑水肿
Keywords:
High mobility group protein B1 Intracerebral hemorrhage Brain edema
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.05.005
文献标志码:
A
摘要:
 目的 探讨脑出血后高迁移率族蛋白B1(high mobility group protein B1,HMGB1)水平的变化及其与脑出血后继发性脑水肿的关系。方法 收集152例幕上性脑出血患者的入院各基线资料及发病24 h时的HMGB1水平和发病后3或4 d复查头颅CT显示的相对水肿体积。结果 初入院的HMGBl水平要显著高于对照组(P<0.05),且24 h患者HMGBl水平与第3或4 d CT复查显示的相对水肿体积呈正相关(r=0.87,P=0.001)。结论 脑出血后HMGBl水平显著升高,且与脑水肿体积进展程度呈正相关。
Abstract:
 ObjectiveTo investigate the changes of HMGB1 after cerebral hemorrhage and analyze the relationship between HMGB1 and cerebral hemorrhage secondary brain edema.Methods We collected 152 cases of acute spontaneous supratentorial intracerebral hemorrhage. All patients were measured serum HMGB1 levels within 6 hours and on 24 h after intracerebral hemorrhage. Then they were given a baseline computerized axial tomography(CT)scan within 6 hours after intracerebral hemorrhage, and review head CT 3 or 4 days later.To control for hematoma volume,the hematoma volume was subtracted from that of the absolute edema.Then the absolute edema volume was divided by the hematoma volume,to express perihematoma edema volume as a ratio of the associated hematoma volume(relative edema volume).The collected results were analysised by SPSS 13.0 statistical software package.Correlations were determined using Spearman’s rank correlation coefficients.Results Compared with normal control, patients’ serum HMGB1 level had a significant increase within 6 hours(P<0.05). Furthmore, serum HMGB1 on 24 hours was correlated well with relative perihematoma edema volume on 3 to 4 days(r=0.87, P=0.001).Conclusion This study provides evidence that serum HMGB1 levels were increased significantly after cerebral hemorrhage, and correlate with the relative perihematoma edema volume on 24 hours. This research can shed a light on evaluation and treatment of intracerebral hemorrhage.

参考文献/References:

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备注/Memo

备注/Memo:
 (2016-02-26收稿 2016-08-08修回)
更新日期/Last Update: 2016-10-30