[1]隋淼 张弢 于扬等.前列地尔注射液对糖尿病合并脑梗死患者血清IL-6及sICAM-1水平的影响[J].卒中与神经疾病杂志,2016,23(05):336-338.[doi:10.3969/j.issn.1007-0478.2016.05.008]
　Sui Miao,Zhang Tao,Yu Yang,et al. Effect of alprostadil injection on IL-6 and sICAM-1 serum level in cerebral infarction patients combined with diabetes[J].Stroke and Nervous Diseases,2016,23(05):336-338.[doi:10.3969/j.issn.1007-0478.2016.05.008]
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前列地尔注射液对糖尿病合并脑梗死患者血清IL-6及sICAM-1水平的影响(/HTML)
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年05期
页码:
336-338
栏目:
论著
出版日期:
2016-10-26

文章信息/Info

Title:
 Effect of alprostadil injection on IL-6 and sICAM-1 serum level in cerebral infarction patients combined with diabetes
作者:
 隋淼 张弢 于扬等
 116001 大连大学附属中山医院内分泌一科
Author(s):
 Sui Miao;  Zhang Tao;  Yu Yang;  et al.
 The First Department of Endocrinology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001
关键词:
 ; 前列地尔注射液 2型糖尿病 脑梗死 白细胞介素6 临床疗效
Keywords:
 ; Alprostadil injection Type 2 diabetes Cerebral infarction Interleukin-6 Clinical efficacy
分类号:
R743 R587.1
DOI:
10.3969/j.issn.1007-0478.2016.05.008
文献标志码:
A
摘要:
 目的 研究前列地尔注射液治疗2型糖尿病合并脑梗死患者的临床疗效及其对血清炎性因子白细胞介素6(IL-6)及可溶性细胞间黏附分子-1(sICAM-1)表达的影响。方法 选取2013年7月～2015年3月本院收治的2型糖尿病合并脑梗死患者98例,随机均分为对照组和治疗组,对照组进行常规治疗,治疗组在对照组治疗基础上加用前列地尔注射液,观察患者的总体疗效、神经功能与生活能力改善情况、炎性因子表达、不良反应。结果 治疗后治疗组总有效率(91.84%)明显高于对照组(77.55%),差异具有统计学意义(P<0.05); 与对照组治疗后比较,治疗组患者生活活动能力评分显著增加,神经功能缺损评分显著减小,差异均具有统计学意义(P<0.05); 与对照组治疗后比较,sICAM-1、IL-6水平明显下降(P<0.01); 治疗组与对照组药物治疗安全性比较,差异无统计学意义(P>0.05)。结论 前列地尔注射液治疗2型糖尿病合并脑梗死患者效果显著,改善患者神经功能,可能与抑制炎性因子表达有关。
Abstract:
 ObjectiveTo observe the effect of alprostadil injection on clinical efficacy and changes of the inflammatory cytokines soluble intercellular adhesion molecule-1(sICAM-1), interleukin-6(IL-6)expression levels in cerebral infarction patients with type 2 diabetes.Methods 98 cerebral infarction cases with type 2 diabetes in our hospital from July, 2013 to March, 2015 were randomly divided into control group and experimental group. Patients in control group received conventional drug treatment, patients in experimental group received conventional treatment plus alprostadil injection. The total clinical effective rates, neurological function, activity of daily living, expression levels of inflammatory cytokines and drug safety were compared between two groups.Results The total effective rate of experimental group(91.84%)was significantly higher than control group(77.55%)(P<0.05). Compared to the control group, the values of activity of daily living increased, and the neurological severity score decreased in experimental group, the differences were significant(P<0.05). Compared with the control group, the levels of sICAM-1 and IL-6 in experimental group dropped obviously, the differences were statistically significant(P<0.01). However, there was no statistical difference on drug safety between two groups(P>0.05).Conclusion Alprostadil injection has a significant clinical effect on improving neurological function in patients of type 2 diabetes with cerebral infarction. Its mechanisms may be related to the down-regulation of expression of inflammatory cytokines.

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备注/Memo

备注/Memo:
 (2016-03-25收稿 2016-04-25修回)
更新日期/Last Update: 2016-10-30