[1]刘杰 任晓艳 张昊.颅内动脉瘤患者手术前后血清MMP-9,NSE,IL-6水平动态变化及其与预后的关系[J].卒中与神经疾病杂志,2021,28(02):202-205.[doi:10.3969/j.issn.1007-0478.2021.02.015]
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颅内动脉瘤患者手术前后血清MMP-9,NSE,IL-6水平动态变化及其与预后的关系()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第28卷
期数:
2021年02期
页码:
202-205
栏目:
论 著
出版日期:
2021-04-20

文章信息/Info

文章编号:
1007-0478(2021)02-0202-05
作者:
刘杰 任晓艳 张昊
463000 河南省驻马店市中心医院急诊科
关键词:
颅内动脉瘤 基质金属蛋白酶9 神经元特异性烯醇化酶 白介素6
分类号:
R543.5
DOI:
10.3969/j.issn.1007-0478.2021.02.015
文献标志码:
A
摘要:
目的 分析颅内动脉瘤患者手术前后血清基质金属蛋白酶9(Matrix metalloproteinase-9,MMP-9)、神经元特异性烯醇化酶(Neuron specific enolase,NSE)、白介素-6(Interleukin-6,IL-6)水平动态变化及其与预后的关系。方法 回顾性分析2016年1月-2019年1月在本院行血管内栓塞治疗的127例颅内动脉瘤患者,根据患者手术1年后的预后情况分为预后良好组(n=95)和预后不良组(n=32); 记录患者入院年龄、有无高血压病、血管痉挛、计算机X线断层扫描(Computed tomography,CT)Fisher分级、Hunt-Hess分级、术后并发症等资料; 分别于手术前、手术1 、7 d后和手术1个月后用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)检测血清MMP-9,NSE和IL-6水平; Pearson相关性分析血清MMP-9,NSE和IL-6水平与术前CT Fisher、Hunt-Hess分级之间的相关性; 受试者工作特征曲线(Receiver operator characteristic curve,ROC)分析血清MMP-9,NSE和IL-6水平对颅内动脉瘤患者术后预后的预测价值。结果 术前CT Fisher分级(OR=1.984,P=0.037)、Hunt-Hess分级(OR=2.063,P=0.018)和有术后并发症(OR=2.026,P=0.033)为影响颅内动脉瘤预后的独立因素(P<0.05); 手术7 d后和手术1个月后预后良好组血清MMP-9,NSE和IL-6水平明显低于预后不良组(P<0.05); 血清MMP-9,NSE和IL-6水平与术前CT Fisher,Hunt-Hess分级呈显著正相关(0.330<r<0.460,P<0.05); 手术7 d后和手术1个月后血清MMP-9,NSE和IL-6水平对颅内动脉瘤患者术后预后具有较高的预测价值(P<0.05),且联合预测的AUC高于单独预测。结论 颅内动脉瘤患者术后血清MMP-9,NSE,IL-6水平升高与患者的预后不良密切相关。

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备注/Memo

备注/Memo:
基金项目:河南省科技攻关计划项目(162102310337)
更新日期/Last Update: 2021-04-20