参考文献/References:
[1] Ashour W,Al-Anwar AD,Kamel AE,et al.Predictors of early infection in cerebral ischemic stroke[J].J Med Life,2016,9(2):163-169.
[2] Peng Z,Li MM,Tan XD,et al.miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2[J].Biochem Pharmacol,2020,177(1):113983.
[3] Zhao JJ,Xiao H,Zhao WB,et al.Remote ischemic postconditioning for ischemic stroke: a systematic review and Meta-Analysis of randomized controlled trials[J].Chin Med J(Engl),2018,131(8):956-965.
[4] Hu YQ,Chen W,Yan MH,et al.Ischemic preconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PERK pathway[J].Eur Rev Med Pharmacol Sci,2017,21(24):5736-5744.
[5] Wu MY,Yiang GT,Liao WT,et al.Current mechanistic concepts in ischemia and reperfusion injury[J].Cell Physiol Biochem,2018,46(4):1650-1667.
[6] He L,He R,Liang RH,et al.Protein expression profiling in the hippocampus after focal cerebral ischemia injury in rats[J].J Integr Neurosci,2018,17(2):149-158.
[7] Mazighi M,Meseguer E,Labreuche J,et al.TRUST-tPA trial: Telemedicine for remote collaboration with urgentists for stroke-tPA treatment[J].J Telemed Telecare,2017,23(1):174-180.
[8] Jang SH,Lee J,Yeo SS.Central post-stroke pain due to injury of the spinothalamic tract in patients with cerebral infarction: a diffusion tensor tractography imaging study[J].Neural Regen Res,2017,12(12):2021-2024.
[9] Kang X,Zuo Z,Hong W,et al.Progress of research on exosomes in the protection against ischemic brain injury[J].Front Neurosci,2019,13(1):1149.
[10] Tkach M,Théry C.Communication by extracellular vesicles: where we are and where we need to go[J].Cell,2016,164(6):1226-1232.
[11] Shao HL,Im H,Castro CM,et al.New technologies for analysis of extracellular vesicles[J].Chem Rev,2018,118(4):1917-1950.
[12] Merchant ML,Rood IM,Deegens JK,et al.Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery[J].Nat Rev Nephrol,2017,13(12):731-749.
[13] Wang X,Chen YH,Zhao ZA,et al.Engineered exosomes with ischemic Myocardium-Targeting peptide for targeted therapy in myocardial infarction[J].J Am Heart Assoc,2018,7(15):e008737.
[14] Sun LP,Dong L,Song K,et al.Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro[J].Sci Rep,2017,7(1):2552.
[15] Yong XE,Yang X,Emory SR,et al.A potent, minimally invasive and simple strategy of enhancing intracellular targeted delivery of Tat peptide-conjugated quantum dots: organic solvent-based permeation enhancer[J].Biomater Sci,2018,6(11):3085-3095.
[16] Croese T,Furlan R.Extracellular vesicles in neurodegenerative diseases[J].Mol Aspects Med,2018,60(1):52-61.
[17] Mcandrews KM,Kalluri R.Mechanisms associated with biogenesis of exosomes in cancer[J].Mol Cancer,2019,18(1):52.
[18] Ludwig N,Yerneni SS,Razzo BM,et al.Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells[J].Mol Cancer Res,2018,16(11):1798-1808.
[19] Shen B,Liu J,Zhang F,et al.CCR2 positive exosome released by mesenchymal stem cells suppresses macrophage functions and alleviates ischemia/Reperfusion-Induced renal injury[J].Stem Cells Int,2016(1):1240301.
[20] Cao H,Qian H,Xu W,et al.Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats[J].Biotechnol Lett,2010,32(5):725-732.
[21] Chen Q,Liu Y,Ding X,et al.Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7[J].Mol Cell Biochem,2020,465(1/2):103-114.
[22] Li G,Xiao LH,Qin H,et al.Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion[J].Cell Cycle,2020,19(9):1022-1035.
[23] Nalamolu KR,Venkatesh I,Mohandass A,et al.Exosomes treatment mitigates ischemic brain damage but does not improve Post-Stroke neurological outcome[J].Cell Physiol Biochem,2019,52(6):1280-1291.
[24] Jiang XC,Gao JQ.Exosomes as novel bio-carriers for gene and drug delivery[J].Int J Pharm,2017,521(1/2):167-175.
[25] Zhao Y,Gan Y,Xu GW,et al.MSCs-Derived exosomes attenuate acute brain injury and inhibit microglial inflammation by reversing CysLT2R-ERK1/2 mediated microglia M1 polarization[J].Neurochem Res,2020,45(5):1180-1190.
[26] Hou K,Li G,Zhao JC,et al.Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway[J].J Neuroinflammation,2020,17(1):46.
[27] Shen H,Yao XY,Li HY,et al.Role of exosomes derived from miR-133b modified MSCs in an experimental rat model of intracerebral hemorrhage[J].J Mol Neurosci,2018,64(3):421-430.
[28] Yang J,Gao F,Zhang Y,et al.Buyang huanwu decoction(BYHWD)enhances angiogenic effect of mesenchymal stem cell by upregulating VEGF expression after focal cerebral ischemia[J].J Mol Neurosci,2015,56(4):898-906.
[29] Mullins RJ,Mustapic M,Goetzl EJ,et al.Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer’s disease[J].Hum Brain Mapp,2017,38(4):1933-1940.
[30] Zhao ZH,Chen ZT,Zhou RL,et al.Increased DJ-1 and α-Synuclein in plasma Neural-Derived exosomes as potential markers for parkinson’s disease[J].Front Aging Neurosci,2018,10(2):438.
[31] Chiva-Blanch G,Suades R,Crespo J,et al.Microparticle shedding from neural progenitor cells and vascular compartment cells is increased in ischemic stroke[J].PLoS One,2016,11(1):e0148176.
[32] Goetzl L,Merabova N,Darbinian N,et al.Diagnostic potential of neural exosome cargo as biomarkers for acute brain injury[J].Ann Clin Transl Neurol,2018,5(1):4-10.
[33] Chen Y,Song YY,Huang J,et al.Increased circulating exosomal miRNA-223 is associated with acute ischemic stroke[J].Front Neurol,2017,8(2):57.
[34] Ji Q,Ji Y,Peng JW,et al.Increased Brain-Specific MiR-9 and MiR-124 in the serum exosomes of acute ischemic stroke patients[J].PLoS One,2016,11(9):e0163645.
[35] Li DB,Liu JL,Wei W,et al.Plasma exosomal miR-422a and miR-125b-2-3p serve as biomarkers for ischemic stroke[J].Curr Neurovasc Res,2018,14(4):330-337.
[36] Zhou JX,Lin C,Chen BC,et al.Increased serum exosomal miR-134 expression in the acute ischemic stroke patients[J].BMC Neurol,2018,18(1):198.
[37] Surman M,Stpień E,Hoja-ukowicz D,et al.Deciphering the role of ectosomes in cancer development and progression: focus on the proteome[J].Clin Exp Metastasis,2017,34(3/4):273-289.
[38] Bian X,Xiao YT,Wu TQ,et al.Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression[J].Mol Cancer,2019,18(1):50.
[39] Agrahari V,Agrahari Vad - Conrad EV,Burnouf PA,et al.Extracellular microvesicles as new industrial therapeutic frontiers[J].Trends Biotechnol,2019,37(7):707-729.
[40] Chen W,Yan YB,Song CD,et al.Microvesicles derived from human Wharton’s Jelly mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal fibrosis by releasing from G2/M cell cycle arrest[J].Biochem J,2017,474(24):4207-4218.
[41] Tang M,Liu P,Li X,et al.Protective action of B1R antagonist against cerebral ischemia-reperfusion injury through suppressing miR-200c expression of Microglia-derived microvesicles[J].Neurol Res,2017,39(7):612-620.
[42] Jy L,Kim E,Choi SM,et al.Microvesicles from brain-extract-treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke[J].Sci Rep,2016,6(1):33038.
[43] Wang J,Chen S,Ma X,et al.Effects of endothelial progenitor cell-derived microvesicles on hypoxia/reoxygenation-induced endothelial dysfunction and apoptosis[J].Oxid Med Cell Longev,2013(1):572729.
[44] Chen BY,Sung CW,Chen C,et al.Advances in exosomes technology[J].Clin Chim Acta,2019,493(1):14-19.
[45] Fais S,O’driscoll L,Borras FE,et al.Evidence-Based clinical use of nanoscale extracellular vesicles in nanomedicine[J].ACS Nano,2016,10(4):3886-3899.
[46] Guix FX,Corbett GT,Cha DJ,et al.Detection of Aggregation-Competent Tau in Neuron-Derived extracellular vesicles[J].Int J Mol Sci,2018,19(3):663.
[47] Stahl PD,Raposo G.Exosomes and extracellular vesicles: the path forward[J].Essays Biochem,2018,62(2):119-124.
[48] Yang D,Zhang W,Zhang HY,et al.Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics[J].Theranostics,2020,10(8):3684-3707.
[49] Chen J,Chopp M.Exosome therapy for stroke[J].Stroke,2018,49(5):1083-1090.