[1]徐志鹏 黎红华 武强等.阿尔茨海默病患者血浆脂联素与Aβ水平的变化[J].卒中与神经疾病杂志,2016,23(01):6-8.[doi:10.3969/j.issn.1007-0478.2016.01.002]
　Xu Zhipeng,Li Honghua,Wu Qiang,et al.Changes of serum adiponectin and Aβ in patients with Alzheimer's disease[J].Stroke and Nervous Diseases,2016,23(01):6-8.[doi:10.3969/j.issn.1007-0478.2016.01.002]
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阿尔茨海默病患者血浆脂联素与Aβ水平的变化()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年01期
页码:
6-8
栏目:
论著
出版日期:
2016-03-01

文章信息/Info

Title:
Changes of serum adiponectin and Aβ in patients with Alzheimer's disease
作者:
徐志鹏 黎红华 武强等
作者单位: 430070 武汉,广州军区武汉总医院神经内科
Author(s):
Xu Zhipeng;  Li Honghua;  Wu Qiang;  et al
Deportment ofNeurology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070
关键词:
阿尔茨海默病 血浆 脂联素 Aβ
Keywords:
Alzheimer's disease Serum Adiponectin Aβ
分类号:
R749.1
DOI:
10.3969/j.issn.1007-0478.2016.01.002
文献标志码:
A
摘要:
目的 探讨AD患者血浆脂联素、Aβ水平的变化及其与MMSE评分的关系。方法 对20例AD患者(AD组)、20例正常认知老年组的血浆脂联素、Aβ40和Aβ42水平进行检测,比较2组血浆脂联素和Aβ水平的差异,并分析血浆脂联素、Aβ与MMSE评分的关系。结果 AD组MMSE评分、血浆脂联素(APN)、Aβ42和Aβ42/Aβ40均低于对照组(P<0.05)。Aβ40水平与Aβ42水平呈显著正相关、与Aβ42/Aβ40呈显著负相关(P<0.01),Aβ42水平与APN水平呈显著正相关(P<0.05),MMSE评分与Aβ42、APN、Aβ42/Aβ40呈显著正相关(P<0.01)。结论 AD组血浆APN、Aβ42水平和Aβ42/Aβ40明显降低,其改变与认知功能评分存在一定的正相关性。
Abstract:
ObjectiveTo investigate the changes of serum adiponectin and Aβ, and the relationships between adiponectin, Aβ and MMSE in patients with Alzheimer's disease(AD).Methods The levels of serum adiponectin, Aβ40 and Aβ42 in twenty AD patients and twenty healthy elderly people were measured and compared.The relationships between serum adiponectin, Aβ and MMSE were analyzed.Results AD patients had lower MMSE score, serum adiponectin, Aβ42 and Aβ42/Aβ40 than healthy elderly controls(P<0.05).Serum Aβ40 level had significantly positive correlation with Aβ42, and negative correlation with Aβ42/Aβ40(P<0.01). There was positive correlation between serum Aβ42 and adiponectin(P<0.05).The levels of serum Aβ42, Aβ42/Aβ40 and adiponectin had significantly positive correlation with MMSE scores(P<0.01).Conclusion The 1evels of serum adiponectin, Aβ42 and Aβ42/Aβ40 were significantly decreased in AD patients, which correlated positively with thescores of cognitive function.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 湖北省自然科学基金项目 2014CFB223
更新日期/Last Update: 1900-01-01