[1]姜海伟 胡晴 鄢艳红等.免疫抑制治疗对36例神经系统副肿瘤综合征相关抗体定量的动态影响[J].卒中与神经疾病杂志,2016,23(02):80-82.[doi:10.3969/j.issn.1007-0478.2016.02.002]
　Jiang Haiwei,Hu Qing,Yan Yanhong,et al.The dynamic effects of immunosuppressive therapy on the related antibody titer for 36 cases of paraneoplastic neurological syndromes[J].Stroke and Nervous Diseases,2016,23(02):80-82.[doi:10.3969/j.issn.1007-0478.2016.02.002]
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免疫抑制治疗对36例神经系统副肿瘤综合征相关抗体定量的动态影响(/HTML)
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
80-82
栏目:
论 著
出版日期:
2016-04-26

文章信息/Info

Title:
The dynamic effects of immunosuppressive therapy on the related antibody titer for 36 cases of paraneoplastic neurological syndromes
作者:
姜海伟 胡晴 鄢艳红等
作者单位:430030 武汉,湖北省第三人民医院神经内科[姜海伟 胡晴 鄢艳红 葛林通 高畅 曹梦莹 刘芳
Author(s):
Jiang Haiwei; Hu Qing;  Yan Yanhong; et al.
Department of Neurology, Third people’s Hospital of Hubei Province,Wuhan 430033
关键词:
免疫抑制治疗 神经系统副肿瘤综合征 抗体定量 动态作用
Keywords:
Immunosuppressive therapy Paraneoplastic neurological syndromes Titer of antibody Dynamic effects
分类号:
R739.4
DOI:
10.3969/j.issn.1007-0478.2016.02.002
文献标志码:
A
摘要:
目的 探讨免疫抑制治疗对神经系统副肿瘤综合征(PNS)相关抗体定量的动态影响。方法 对36例神经系统副肿瘤综合征进行规范化的免疫抑制治疗(包括糖皮质激素或环磷酰胺),在治疗前及治疗开始后1周、4周、治疗后1周,结束后3月分别对患者血清抗-Hu抗体、抗-Yo抗体、 抗-Ri抗体进行定量检测(酶联免疫吸附试验,ELISA),对比治疗前后相关抗体滴度的动态变化情况。结果 血清抗-Hu抗体:治疗开始后1周抗体滴度即开始持续下降(P<0.01),但在治疗后3月,抗体滴度反弹升高,与治疗前比较没有明显差异(P>0.05)。抗-Yo抗体及抗-RI抗体在治疗开始后抗体滴度同样呈持续下降趋势,其中抗-Yo抗体治疗开始后1周下降有明显差异(P<0.01),抗-RI抗体在治疗后4周明显下降(P<0.01),但治疗结束后1周、3月抗体滴度有所上升,但与治疗前比较仍显著下降(P<0.01)。结论 免疫抑制治疗在治疗期间能够一定程度上有效抑制PNS相关抗体的滴度,但对于血清抗-Hu抗体远期抑制效果欠佳。
Abstract:
ObjectiveTo investigate the dynamic effects of immunosuppressive therapy on the antibody titer associated with paraneoplastic neurological syndromes.Methods 36 cases of paraneoplastic neurological syndromes were given standardized immunosuppressive therapy(including corticosteroids or cyclophosphamide). The serum antibodies of anti -Hu, anti -Yo and anti -Ri were quantitative detected by ELISA method before treatment,one week during treatment, four weeks during treatment,one week after treatment and three months after treatment respectively. The dynamic changes of antibody titers were compared before and after treatment.Results The antibody titer of anti–Hu began to decline at one week during treatment(P<0.01), but the titer increased in three months after treatment, and there was no statistical significance compared with the titer before treatment(P>0.05). The titer of Anti -Yo and anti Ri both showed a downward trend after the beginning of treatment. The anti -Yo declined in one week and the anti - Ri declined in four weeks during treatment(P<0.01). After the end of the treatment, the titer showed an increased trend, but still significantly decreased compared with before treatment(P<0.01).Conclusion Immunosuppressive therapy can effectively inhibit the titer of antibody associated with PNS in a certain extent during the treatment, but there is not a long-term effect for Anti -Hu.

参考文献/References:

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备注/Memo

备注/Memo:
(2015-12-16收稿)
更新日期/Last Update: 2016-05-04