[1]张萌 钟池 付文玉等.胰岛素受体底物-2的Gly1057Asp基因多态性与颈动脉粥样硬化性狭窄相关性的研究[J].卒中与神经疾病杂志,2016,23(02):83-87.[doi:10.3969/j.issn.1007-0478.2016.02.003]
　Zhang Meng,Zhong Chi,Fu Wenyu,et al.The association between Gly1057Asp polymorphism of insulin receptor substrate-2 and carotid[J].Stroke and Nervous Diseases,2016,23(02):83-87.[doi:10.3969/j.issn.1007-0478.2016.02.003]
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胰岛素受体底物-2的Gly1057Asp基因多态性与颈动脉粥样硬化性狭窄相关性的研究(/HTML)
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
83-87
栏目:
论著
出版日期:
2016-04-26

文章信息/Info

Title:
The association between Gly1057Asp polymorphism of insulin receptor substrate-2 and carotid
作者:
张萌 钟池 付文玉等
作者单位:261000 山东省潍坊医学院附属潍坊市人民医院神经内科[张萌 钟池(通信作者)王洪海 许晓伟 刘涵瑜]; 潍坊医学院组织与胚胎教研室(付文玉)
Author(s):
Zhang Meng; Zhong Chi; Fu Wenyu; et al.
Department of Neurology, Weifang People’s Hospital Affiliated to Weifang Medical University, Weifang 261000
关键词:
胰岛素受体底物-2 单核苷酸多态性 颈动脉粥样硬化 危险因素
Keywords:
Insulin receptor substrate-2 Single nucleotide polymorphism Carotid atherosclerosis Risk factors
分类号:
R749.1
DOI:
10.3969/j.issn.1007-0478.2016.02.003
文献标志码:
A
摘要:
目的 探讨胰岛素受体底物-2的Gly1057Asp基因多态性与颈动脉粥样硬化性狭窄的相关性。方法 选择96例行颈部血管彩超示颈动脉狭窄≥50%的北方汉族人为实验组以及同期79例体检健康者作为对照组,通过聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术检测所有入选患者的Gly1057Asp基因多态性,比较2组的等位基因频率、基因型频率以及Gly1057Asp基因多态性对颈动脉狭窄的影响。结果 实验组中G等位基因频率(78.6%)明显高于对照组(68.4%)(P<0.05); 实验组中G/A+A/A基因型频率(36.5%)明显低于对照组(51.9%)(P<0.05)。携带等位基因G的个体患有颈动脉粥样硬化性狭窄的风险是非等位基因G携带者的1.99倍(OR=1.994,95%CI=1.068～3.761)。结论 胰岛素受体底物-2的Gly1057Asp基因多态性可能与颈动脉粥样硬化性狭窄有关,等位基因G可能是颈动脉粥样硬化性狭窄的独立危险因素。
Abstract:
ObjectiveTo evaluate the association between the Gly1057Asp polymorphism of insulin receptor substrate-2 and carotid atherosclerosis. To explore the genetic mark of the susceptibility of carotid artery stenosis.Methods 96 Patients with greater than or equal to 50% carotid artery stenosis and 79 healthy controls who were the Han nationality in the north were choosed to detect the Gly1057Asp polymorphism by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique, and all of them had been received cervical vascular color ultrasonic inspection. The allele frequency, genotypes frequency between the two groups were compared. The relationship between Gly1057Asp polymorphism and carotid ar-tery stenosis was explored.Results The G allele frequency in the experimental group(78.6%)was significantly higher than that in the control group(68.4%)(P<0.05); The G/A+A/A genotypes in the experimental group(36.5%)were obviously lower than that in the control group(51.9%)(P<0.05). The patients with allele G had a 1.99-fold increased risk for carotid artery stenosiscompared with those people who had no allele G(OR=1.994, 95%CI 1.068-3.761).Conclusions The Gly1057Asp polymorphism of insulin receptor substrate-2 is probably associated with carotid artery stenosis,and the allele G may be arisk factor for carotid artery stenosis.

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备注/Memo

备注/Memo:
(2015-03-11收稿 2015-09-29修回)
更新日期/Last Update: 2016-05-04