[1]刘洁 王前 郭艳敏等.DDAH2C-449G基因多态性与动脉粥样硬化血栓形成性脑梗死的相关性[J].卒中与神经疾病杂志,2016,23(02):88-90.[doi:10.3969/j.issn.1007-0478.2016.02.004]
　Liu Jie,Wang Qian,Guo Yanmin,et al.Relationship between dimethylarginine dimethylaminohydrolase 2C-449G dene polymorphism and atherothrombotic cerebral infarction[J].Stroke and Nervous Diseases,2016,23(02):88-90.[doi:10.3969/j.issn.1007-0478.2016.02.004]
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
88-90
栏目:
论著
出版日期:
2016-04-26

文章信息/Info

Title:
Relationship between dimethylarginine dimethylaminohydrolase 2C-449G dene polymorphism and atherothrombotic cerebral infarction
作者:
刘洁 王前 郭艳敏等
作者单位:071000 河北保定市第一中心医院[刘洁 王前 郭艳敏(通信作者)卢军栋 齐凡星]
Author(s):
Liu Jie;  Wang Qian;  Guo Yanmin;  et al.
First Central Hospital of Baoding, Baoding 071000
关键词:
AIS 遗传 基因 DDAH2C-449G 聚合酶链反应
Keywords:
Atherothrombotic cerebral infarction Genetics Gene DDAH2C-449G Polymerase chain reaction
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.02.004
文献标志码:
A
摘要:
目的 探讨DDAH2C-449G基因多态性与动脉粥样硬化血栓形成性脑梗死(atherothrombotic infarct of brain)的关系。方法 共纳入345例脑梗死患者和201例对照组人群,以DDAH2C-449G基因为遗传标志,采用聚合酶链式反应(PCR)和限制性片段长度多态性技术(RFLP)检测DDAH2C-449G基因多态性。结果 动脉粥样硬化血栓形成性脑梗死GG基因型、G等位基因频率较对照组高(P<0.05).结论 DDAH2C-449G基因多态性可能与动脉粥样硬化血栓形成性脑梗死发病有关,G等位基因可能是动脉粥样硬化血栓形成性脑梗死的易感基因。
Abstract:
ObjectiveTo investigate the relationship between Dimethylarginine Dimethylaminohydrolase 2C-449G Gene and atherothrombotic cerebral infarction.Methods A total of 345 patients with ischemic stroke and 201 controls were enrolled in the study. DDAH2C-449G gene was chosen as the genetic marker. Polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)were used to detect DDAH2 gene polymorphism.Results GG genotype and G allele frequency in atherothrombotic cerebral infarct group were higher than those in control group(P<0.05).Conclusion DDAH2C-449G gene polymorphism may be related to the incidence of atherothrombotic cerebral infarction. G allele may be the predisposing gene of atherothrombotic cerebral infarction.

参考文献/References:

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备注/Memo

备注/Memo:
(2015-12-10收稿 2015-12-27修回)
更新日期/Last Update: 2016-05-04