[1]周春亭 王朝晖.脑出血后发生迟发性脑水肿的相关危险因素分析[J].卒中与神经疾病杂志,2016,23(02):91-93.[doi:10.3969/j.issn.1007-0478.2016.02.005]
　hemorrhageZhou Chunting,Wang Zhaohui..The analysis of the related risked factors for delayed cerebral edema after intracerebral[J].Stroke and Nervous Diseases,2016,23(02):91-93.[doi:10.3969/j.issn.1007-0478.2016.02.005]
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脑出血后发生迟发性脑水肿的相关危险因素分析(/HTML)
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
91-93
栏目:
论 著
出版日期:
2016-04-26

文章信息/Info

Title:
The analysis of the related risked factors for delayed cerebral edema after intracerebral
作者:
周春亭 王朝晖
作者单位:430050 武汉科技大学附属汉阳医院(周春亭 王朝晖)
Author(s):
hemorrhageZhou Chunting;  Wang Zhaohui.
Hanyang Hospital Affiliated to Wuhan University of Science and Technology, DepartmentⅡof Internal Neurology, Wuhan 430050
关键词:
脑出血 迟发性脑水肿 危险因素 多因素分析
Keywords:
Intracerebral hemorrhage Delayed cerebral edema Risked factor Multivariate analysis
分类号:
R743.34
DOI:
10.3969/j.issn.1007-0478.2016.02.005
文献标志码:
A
摘要:
目的 探讨脑出血后发生迟发性脑水肿的相关危险因素。方法 回顾性分析本院神经内科2012年7月～2014年6月158例非手术治疗的脑出血患者的临床资料,根据患者脑水肿情况分为迟发性脑水肿组(观察组73例)和非迟发性脑水肿组(对照组85例),对可能影响脑出血后发生迟发性脑水肿的因素危险因素进行单因素和多因素Logistical回归分析。结果 单因素分析表明2组患者年龄、高血压和吸烟史、美国国立卫生研究卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、血糖值、纤维蛋白原、基质金属蛋白酶9(Matrix Metalloproteinases 9,MMP-9)、出血量有明显的差异(P<0.05); 多因素Logistical回归分析表明纤维蛋白原,MMP-9,NIHSS评分、血糖水平及出血量是脑出血后发生迟发性脑水肿的独立危险因素。结论 纤维蛋白原,MMP-9,NIHSS评分,血糖水平及出血量是脑出血后发生迟发性脑水肿的独立危险因素。
Abstract:
ObjectiveTo analyse the related risked factors for delayed cerebral edema after intracerebral hemorrhage.Methods The clinical data of 158 patients with intracerebral hemorrhage treaded with conservative treatment in our hospital from July 2012 to June 2014 were analyzed retrospectively. According to the cerebral edema features, patients were divided into delayed cerebral edema group(observation group including 73 cases)and without delayed cerebral edema group(control group including 85 cases). All relative risked factors associated with delayed cerebral edema were analyzed by the univariate analysis and multiple logistical regression analysis step by step.Results The result of univariate analysis showed that the differences of age, the history of hypertension and smoking, NIHSS scores, the value of blood glucose, fibrinogen, matrix metalloproteinases 9 and hematoma volume between two groups were statistically significant(P<0.05).Multivariate Logistical regression analysis showed that fibrinogen, matrix metalloproteinases 9, NIHSS scores, the value of blood glucose and the hematoma volume were the independent risked factors for delayed cerebral edema after intracerebral hemorrhage.Conclusion Fibrinogen, matrix metalloproteinases 9, NIHSS scores, the value of blood glucose and the hematoma volume were the independent risked factors for delayed cerebral edema after intracerebral hemorrhage.

参考文献/References:

[1] Venkatasubramanian C,Mlynash M,Finley-Caulfield A,et al.Natural history of perihematomal edema after intracerebral hemorrhage measured by serial magnetic resonance imaging[J].Stroke,2011,42(1):73-80.
[2] Xi GH,Keep RF,Hoff JT.Mechanisms of brain injury after intracerebral haemorrhage[J].The Lancet Neurology,2006,5(1):53-63.
[3] 黄园园,陈吉相,王芳,等.脑出血后迟发性脑水肿与纤维蛋白原等相关因素的分析[J].卒中与神经疾病,2011,18(6):335-338, 375.
[4] 陈娟,赵爱英.脑出血后迟发性脑水肿与甘露醇治疗的临床观察[J].神经病学与神经康复学杂志,2009,6(1):39-41.
[5] Grände PO,Romner B.Osmotherapy in brain edema: a questionable therapy[J].J Neurosurg Anesthesiol,2012,24(4):407-412.
[6] Wu H,Zhang ZY,Li Y,et al.Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: Correlation with brain edema[J].Neurochem Int,2010,57(3):248-253.
[7] Rosell A,Ortega-Aznar A,Alvarez-Sab n J,et al.Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke[J].Stroke,2006,37(6):1399-1406.
[8] 顾双双,张均,韩玲,等.脑出血后迟发性脑水肿与血浆基质金属蛋白酶9等相关因素的分析[J].中国脑血管病杂志,2015,12(6):297-301.
[9] Brott T,Adams HP,Olinger CP,et al.Measurements of acute cerebral infarction: a clinical examination scale[J].Stroke,1989,20(7):864-870.
[10] 王小蓉,张志,李小刚.实验性脑出血后高血糖致能量代谢障碍加重脑损伤的可能机制[J].泸州医学院学报,2012,35(1):87-89.
[11] Ding R,Chen Y,Yang S,et al.Blood-brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation[J].Brain Res,2014,1571(1):25-38.

备注/Memo

备注/Memo:
(2015-10-09收稿 2015-11-20修回)
更新日期/Last Update: 2016-05-04