[1]朱骏 潘杨 沈柏等.帕金森病患者嗅觉减退的相关因素分析[J].卒中与神经疾病杂志,2016,23(02):102-106.[doi:10.3969/j.issn.1007-0478.2016.02.008]
　Zhu Jun,Pan Yang,Shen Bo,et al.The incidence and associated factors of hyposmia in patients with Parkinson’s disease[J].Stroke and Nervous Diseases,2016,23(02):102-106.[doi:10.3969/j.issn.1007-0478.2016.02.008]
点击复制

帕金森病患者嗅觉减退的相关因素分析(/HTML)
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
102-106
栏目:
论 著
出版日期:
2016-04-26

文章信息/Info

Title:
The incidence and associated factors of hyposmia in patients with Parkinson’s disease
作者:
朱骏 潘杨 沈柏等
作者单位:210029 南京医科大学附属脑科医院老年神经科[朱骏 潘杨 沈柏 张丽(通信作者)]
Author(s):
Zhu Jun;  Pan Yang;  Shen Bo;  et al.
Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029
关键词:
帕金森病 嗅觉减退 淡漠
Keywords:
Parkinson’s disease Hyposmia Apathy
分类号:
R742.5
DOI:
10.3969/j.issn.1007-0478.2016.02.008
文献标志码:
A
摘要:
目的 探讨帕金森病患者嗅觉减退的发生率以及相关因素。方法 收集463例帕金森病(PD)患者基本信息,并通过量表系统性评估运动及非运动症状, PD非运动量表“是否有嗅觉减退”项回答“是”者纳入嗅觉减退组,回答“否”者纳入非嗅觉减退组。结果 帕金森病患者嗅觉减退发生率为33.9%,86%的患者嗅觉减退出现在运动症状之前,并且与性别、年龄、起病年龄、运动症状、疾病严重程度无明显关系。伴有嗅觉减退患者的情绪障碍如焦虑、抑郁、淡漠较重,并且睡眠和认知功能较差。高质量的睡眠及吸烟是PD嗅觉减退的保护因素,淡漠是危险因素。结论 合并嗅觉减退患者可能合并更加严重的情绪、睡眠及认知障碍。
Abstract:
ObjectiveTo explore the prevalence and clinical correlates of hyposmia in patients with Parkinson’s disease(PD).Methods A cross-sectional analysis of 463 patients with PD was conducted. Each subject was categorized as with hyposmia or with normal olfactory function using the Non-Motor Symptoms Scale(NMS).Results One hundred and fifty-seven(33.9%)patients exhibited olfactory dysfunction. In our study, hyposmia was reported to precede the onset of motor symptoms by up to 86%.The percentages of history of smoking and drinking alcohol, and the NMS, Hamilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA), PD Sleep Scale(PDSS)and Montreal Cognitive Assessment(MoCA)scores were significantly different in two groups. The forward binary logistic regression model indicated that apathy, sleep quality and history of smoking were associated with olfactory dysfunction.Conclusion Hyposmia is a relatively common debilitating symptom in PD patients. It is not only related to non-motor symptoms especially apathy and sleep quality of PD but also related to smoking.

参考文献/References:

[1] 中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病治疗指南[J].中华神经科杂志,2014,47(6):428-433.
[2] Antonini A,Barone P,Marconi R,et al.The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of Life[J].J Neurol,2012,259(12):2621-2631.
[3] Morley JF,Duda JE.Neuropsychological correlates of olfactory dysfunction in Parkinson’s disease[J].J Neurol Sci,2011,310(1/2, SI):228-230.
[4] Ross GW,Petrovitch H,Abbott RD,et al.Association of olfactory dysfunction with risk for future Parkinson’s disease[J].Ann Neurol,2008,63(2):167-173.
[5] Kranick SM,Duda JE.Olfactory dysfunction in Parkinson’s disease[J].Neurosignals,2008,16(1):35-40.
[6] Hughes AJ,Daniel SE,Kilford L,et al.Accuracy of clinical diagnosis of idiopathic Parkinson’s disease:a clinico-pathological study of 100 cases[J].J Neurol Neurosurg Psychiatry,1992,55(3):181-184.
[7] Chaudhuri KR,Martinez-Martin P,Schapira AH,et al.International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study[J].Mov Disord,2006,21(7):916-923.
[8] Pont-Sunyer C,Hotter A,Gaig C,et al.The onset of nonmotor symptoms in Parkinson’s disease(the ONSET PD study)[J].Mov Disord,2015,30(2):229-237.
[9] Berendse HW,Roos DS,Raijmakers P,et al.Motor and non-motor correlates of olfactory dysfunction in Parkinson’s disease[J].J Neurol Sci,2011,310(1/2, SI):21-24.
[10] Cramer CK,Friedman JH,Amick MM.Olfaction and apathy in Parkinson’s disease[J].Parkinsonism Relat Disord,2010,16(2):124-126.
[11] Siderowf A,Jennings D,Eberly S,et al.Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study[J].Movement Disorders,2012,27(3):406-412.
[12] Hong JY,Sunwoo MK,Ham JH,et al.Apathy and olfactory dysfunction in early Parkinson’s disease[J].J Mov Disord,2015,8(1):21-25.
[13] Morley JF,Weintraub D,Mamikonyan E,et al.Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson’s disease[J].Movement Disorders,2011,26(2):S157.
[14] Parrao T,Chana P,Venegas P,et al.Olfactory deficits and cognitive dysfunction in Parkinson’s disease[J].Neurodegener Dis,2012,10(1/4):179-182.
[15] Baba T,Kikuchi A,Hirayama K,et al.Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson’s disease: a 3 year longitudinal study[J].Brain,2012,135(Pt 1):161-169.
[16] Bohnen NI,Mueller ML,Kotagal VA,et al.Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson’s disease[J].Brain,2010,133(6):1747-1754.
[17] Shimada H,Hirano S,Shinotoh H,et al.Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET[J].Neurology,2009,73(4):273-278.
[18] Miyamoto T,Miyamoto M,Iwanami MA,et al.Olfactory dysfunction in idiopathic REM sleep behavior disorder[J].Sleep Med,2010,11(5):458-461.
[19] Stiasny-Kolster K,Doerr Y,Moller JC,et al.Combination of `idiopathic’ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT[J].Brain,2005,128(1):126-137.
[20] Fantini ML,Postuma RB,Montplaisir JA.Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder[J].Brain Res Bull,2006,70(4/6):386-390.
[21] Stiasny-Kolster K,Clever SC,Moller JC,et al.Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder[J].Brain,2007,130(Pt 2):442-449.
[22] Sharer JD,Leon-Sarmiento FE,Morley JF,et al.Olfactory dysfunction in Parkinson’s disease:Positive effect of cigarette smoking[J].Mov Disord,2015,30(6):859-862.
[23] Lucassen EB,Sterling NW,Lee EY,et al.History of smoking and olfaction in Parkinson’s disease[J].Mov Disord,2014,29(8):1069-1074.
[24] Chambers RP,Call GB,Meyer D,et al.Nicotine increases lifespan and rescues olfactory and motor deficits in a Drosophila model of Parkinson’s disease[J].Behav Brain Res,2013,253:95-102.
[25] Mandairon N,Peace ST,Boudadi K,et al.Compensatory responses to age-related decline in odor quality acuity: Cholinergic neuromodulation and olfactory enrichment[J].Neurobiol Aging,2011,32(12):2254-2265.
[26] Shiba K,Machida T,Uchida S,et al.Effects of nicotine on regional blood flow in the olfactory bulb in rats[J].Eur J Pharmacol,2006,546(1/3):148-151.
[27] Tunez I,Drucker-Colin R,Montilla P,et al.Protective effect of nicotine on oxidative and cell damage in rats with depression induced by olfactory bulbectomy[J].Eur J Pharmacol,2010,627(1/3):115-118.
[28] Zhang D,Jiang H,Xie J.Alcohol intake and risk of Parkinson’s disease:a meta-analysis of observational studies[J].Mov Disord,2014,29(6):819-822.

备注/Memo

备注/Memo:
(2015-11-05收稿)
更新日期/Last Update: 2016-05-04