[1]卢军 万绪怀.影响急性脑梗死出血性转化的危险因素[J].卒中与神经疾病杂志,2016,23(02):110-113.[doi:10.3969/j.issn.1007-0478.2016.02.010]
　Lu Jun,Wang Xuhuai..Risk factors influencing the hemorrhagic transformation after acute ischemic stroke[J].Stroke and Nervous Diseases,2016,23(02):110-113.[doi:10.3969/j.issn.1007-0478.2016.02.010]
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年02期
页码:
110-113
栏目:
论著
出版日期:
2016-04-26

文章信息/Info

Title:
Risk factors influencing the hemorrhagic transformation after acute ischemic stroke
作者:
卢军 万绪怀
作者单位:445400 湖北省恩施州利川市和谐医院(卢军 万绪怀)
Author(s):
Lu Jun;  Wang Xuhuai.
Department of Neurology, Lichuan People’s Hospital, Enshi 445400
关键词:
脑梗死 脑出血 危险因素 预后
Keywords:
Stroke Cerebral ischemia Cerebral hemorrhage Risk factors Prognosis
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.02.010
文献标志码:
A
摘要:
目的 探讨急性脑梗死的出血性转化的危险因素。方法 收集2012年1月～2015年1月在湖北省恩施州利川市人民医院神经内科住院的急性脑梗死患者的临床及实验室检查资料,并在入院后10 d内行头颅CT复查,采用多变量logistic回归分析确定出血性转化的独立危险因素。结果 共纳入345例急性脑梗死患者,其中男205例,女140例,101例发生出血性转化。出血性转化组的年龄、脑梗死体积、脑卒中史或TIA史、高血压病、糖尿病、抗凝药和房颤的比例均显著高于非出血性转化组(P<0.05),而2组抗血小板聚集药、他汀类、高脂血症史、吸烟或饮酒史无明显差异(P>0.05)。多变量logistic回归分析显示年龄(OR=1.168,95%,CI=1.059～3.412; P=0.021)、梗死体积(OR=3.461,95%C1=1.317～6.270; P=0.044)和房颤(OR=1.284,95%C1= 1.117～2.903; P=0.015)为出血性转化的独立危险因素。结论 急性脑梗死患者出血性转化的发生率为29.3%,年龄、脑梗死体积和房颤为出血性转化的独立危险因素,绝大多数出血性转化不会加重临床症状,临床症状加重的患者主要是脑实质血肿型。
Abstract:
ObjectiveTo investigate the independent risk factors of hemorrhagic transformation after acute ischemic stroke.Methods The clinical data of patients with acute ischemic stroke in Renmin hospital of Lichuan city in EnShi province were collected from January 2012 to January 2015, and cranium CT scan was rechecked during 10 days after the patient admission. Multivariate logistic regression analysis was used to determine the independent risk factors for hemorrhagic transformation.Results A total of 345 patients with acute ischemic stroke were enrolled and 101 of them had hemorrhagic transformation.The age was significantly older and infarct volume was markedly larger in hemorrhagic transformation group than those in the non- hemorrhagic transformation group(P<0.05). The proportions of history of stroke and TIA, hypertension, diabetes, anticoagulation drug and atrial fibrillation were significantly higher than those in the non- hemorrhagic transformation group(P<0.05). There were no significantly difference between two groups in antiplatelets drug, statins, history of hyperlipemia, drinking and smoking(P>0.05). Multivariate logistic regression analysis showed that age(OR:1.168,95%CI:1.059～3.412; P=0.021), infarct volume(OR:3.461,95%C1:1.317～6.270; P=0.044)and atrial fibrillation(OR:1.284,95%C1: 1.117～2.903; P=0.015)were the independent risk factors for hemorrhagic transformation.Conclusion The incidence of hemorrhagic transformation in patients with acute ischemic stroke was 29.3%.Age, infarct volume and atrial fibrillation were the independent risk factors for hemorrhagic transformation. The clinical symptom of most of the patients with hemorrhagic transformation was not more serious, but the clinical symptom may be get worse in the type of parenchymal hemorrhage.

参考文献/References:

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备注/Memo

备注/Memo:
(2015-10-08收稿)
更新日期/Last Update: 2016-05-04