[1]吴金龙,钟池,王磊,等.急性脑梗死患者氯吡格雷抵抗的相关因素研究[J].卒中与神经疾病杂志,2016,23(06):395-398.[doi:10.3969/j.issn.1007-0478.2016.06.003]
　Wu Jinlong*,Zhong Chi,Wang Lei,et al.Relevent factors for clopidogrel resistance in patients with acute cerebral infarction[J].Stroke and Nervous Diseases,2016,23(06):395-398.[doi:10.3969/j.issn.1007-0478.2016.06.003]
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急性脑梗死患者氯吡格雷抵抗的相关因素研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年06期
页码:
395-398
栏目:
论 著
出版日期:
2016-12-30

文章信息/Info

Title:
Relevent factors for clopidogrel resistance in patients with acute cerebral infarction
文章编号:
1007-0478(2016)06-0395-04
作者:
吴金龙; 钟池; 王磊; 李文; 王绍博
261053 山东省潍坊市潍坊医学院神经病学教研室(吴金龙); 潍坊医学院附属潍坊市人民医院神经内科[ 钟池(通信作者)王磊 李文 王绍博]
Author(s):
Wu Jinlong*; Zhong Chi; Wang Lei; et al.
*Department of Neurology,Weifang Medical University,Weifang 261053
关键词:
急性脑梗死 氯吡格雷抵抗 血栓弹力图(TEG)
Keywords:
Acute cerebral infarction Clopidogrel resistance TEG
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2016.06.003
文献标志码:
A
摘要:
目的 探讨急性脑梗死患者氯吡格雷抵抗(clopidogrel resisitance,CR)的相关因素。方法 收集急性脑梗死患者100例,入院后连续口服氯吡格雷7 d后空腹抽取肘静脉血,用血栓弹力图(thromboelastograms,TEG)测得二磷酸腺苷(adenosine diphosphate,ADP)受体途径诱导的血小板抑制率,将患者分为氯吡格雷抵抗组(CR)和氯吡格雷敏感组(clopidogrel sensitivity,CS); 根据2组患者的临床检测水平和Logistic回归分析引起CR的因素。结果 31例患者出现氯吡格雷抵抗,发生率为31%。单因素分析发现并发2型糖尿病、LDL-C水平、空腹血糖水平(FPG)差异明显(P<0.05)。多因素Logistic回归分析发现,2型糖尿病(OR=13.198,P<0.05)、LDL-C水平(OR=0.349,P<0.05)是引起CR的独立危险因素。结论 部分急性脑梗死患者会出现氯吡格雷抵抗,2型糖尿病、LDL-C水平是其独立危险因素。
Abstract:
ObjectiveTo explore the relevent factors for clopidogrel resistance in patients with acutecerebral infarction.Methods One hundred patients with acute ischemic stroke were recruited. Whole blood samples were collected after clopidogrel was administered for 7 days,the inhibitory rates of ADP receptor pathway in platelets were detected by TEG. Patients were divided into two groups: CR group and CS group.Clinical data in the two groups were compared and logistic regression analysis was performed for the factors of CR.Results There were 31 cases with CR and the occurrence rata of CR was 31%,Single factor analysis showed that the type 2 diabetes mellitus、LDL-C levels 、 FPG levels were obviously different between two groups(P<0.05), Logistic regression analysis revealed that type 2 diabetes mellitus(OR=13.198,P<0.05)and the LDL-C level(OR=0.349,P<0.05)were independent risk factors of CR.Conclusion CR may occur in some patients with acute cerebral infarction, and type 2 diabetes mellitus, elevated LDL-C level were independent risk factors. Cerebrovascular adverse events are apt to recur in these patients.

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更新日期/Last Update: 2016-12-20