[1]董晓宇,佡剑非.狼疮性脑病的临床特征及发生、发展的相关因素分析[J].卒中与神经疾病杂志,2016,23(06):407-411.[doi:10.3969/j.issn.1007-0478.2016.06.006]
　Dong Xiaoyu,Nao Jianfei..Clinical characteristic and correlative factors for lupus erythematosus encephalopathy[J].Stroke and Nervous Diseases,2016,23(06):407-411.[doi:10.3969/j.issn.1007-0478.2016.06.006]
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狼疮性脑病的临床特征及发生、发展的相关因素分析()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年06期
页码:
407-411
栏目:
论 著
出版日期:
2016-12-30

文章信息/Info

Title:
Clinical characteristic and correlative factors for lupus erythematosus encephalopathy
文章编号:
1007-0478(2016)06-0407-05
作者:
董晓宇; 佡剑非
110004 沈阳,中国医科大学附属盛京医院神经内科[董晓宁 佡剑非(通信作者)]
Author(s):
Dong Xiaoyu; Nao Jianfei.
Department of Neurology,The Sheng Jing Hospital Affiliated of China Medical University,Shenyang 110004
关键词:
系统性红斑狼疮 脑病 临床特征 危险因素
Keywords:
Systemic lupus erythematosus Encephalopathy Clinical characteristic Risk factors
分类号:
R742
DOI:
10.3969/j.issn.1007-0478.2016.06.006
文献标志码:
A
摘要:
目的 分析狼疮性脑病患者的临床特点及发生、发展的相关因素。方法 回顾性分析53例狼疮性脑病患者的临床资料,按随机配对原则分层抽取53例同期住院治疗诊断为系统性红斑狼疮(SLE)而无脑病的患者作为对照组,比较2组患者的临床资料,分析2组患者的临床差异,并进一步推断狼疮性脑病的可能危险因素。结果 神经系统症状中最为常见的分别是头痛38例(71.7%); 脑血管病24例(45.3%); 癫痫12例(22.6%); 狼疮性脑病组中血白细胞数升高、血小板计数减低、尿蛋白阳性率均明显高于对照组,抗核抗体(ANA)阳性例数低于对照组(P<0.05)。Logistic回归分析显示SLE患者白细胞计数、血小板计数以及尿蛋白阳性与狼疮脑病有关(P<0.05)。结论 头痛是狼疮性脑病最常见的神经系统症状; 血白细胞数升高、血小板计数减少可能是SLE患者发生狼疮性脑病的危险因素; 白细胞计数、血小板计数以及尿蛋白阳性可能与狼疮脑病有关。
Abstract:
ObjectiveTo analyze the clinical characteristic and the correlative factors about the occurrence and development of lupus erythematosus encephalopathy(LEE).Methods Retrospectively analyzed 53 LEE patients and 53 SLE patients who without LEE symptoms as the control group,which selected by the random layered matching method.Compare the clinical data of patients in two groups,observe and analyz the clinical difference of two groups,and the possible risk factors of lupus encephalopathy will be further deduced.Results The most common neurological symptoms are: headache in 38 patients(71.7%), cerebrovascular disease in 24 patients(45.3%),epilepsy in 12 patients(22.6%).In LEE group,white blood cell elevated and platelet counts reduced,increased urinary protein positive rate were significantly higher than the non-LEE group,antinuclear antibody(ANA)positive cases were less than non-LEE group,the difference between the two groups had statistical significance(P<0.05). Logistic regression analysis showed that correlation between SLE patients' white blood cell count,platelet count,and urinary protein positive are statistically significant correlation with LEE(P<0.05).Conclusion Headache is the most common neurological symptoms in LEE; elevated white blood cell,reduced platelet count are the risk factors of patients with LEE; leukocyte count,platelet count,and urinary protein positive may be related to the occurrence of LEE.

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更新日期/Last Update: 2016-12-20