[1]王娟娟,贾蕾.血清基质金属蛋白酶-10水平与中老年颈动脉狭窄的相关性分析[J].卒中与神经疾病杂志,2016,23(06):416-419.[doi:10.3969/j.issn.1007-0478.2016.06.008]
　Wang Juanjuan,Jia Lei..Correlation between serum matrix metalloproteinase-10 levels and the aged with carotid artery stenosis[J].Stroke and Nervous Diseases,2016,23(06):416-419.[doi:10.3969/j.issn.1007-0478.2016.06.008]
点击复制

血清基质金属蛋白酶-10水平与中老年颈动脉狭窄的相关性分析()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年06期
页码:
416-419
栏目:
论 著
出版日期:
2016-12-30

文章信息/Info

Title:
Correlation between serum matrix metalloproteinase-10 levels and the aged with carotid artery stenosis
文章编号:
1007-0478(2016)06-0416-04
作者:
王娟娟; 贾蕾
716000 陕西省延安大学附属医院神经内科
Author(s):
Wang Juanjuan; Jia Lei.
Department of Neurology, Affiliated Hospital of Yan'an University, Yan'an 716000
关键词:
目的 探讨中老年颈动脉狭窄患者血清基质金属蛋白酶-10(MMP-10)的变化情况及其与主要危险因素、伴随症状、狭窄程度、狭窄部位和斑块性质之间的关系。方法 选择2014年3月～2016年2月在本院治疗的106例老年颈动脉狭窄患者作为病例组; 随机选择同期在本院体检的80例无颈动脉狭窄的老年健康体检者作为对照组;  收集所有研究对象颈动脉超声检查及其他临床资料; 并采集血清检测患者血清MMP-10水平。结果 病例组患者血清MMP-10水平显著高于对照组(p<; 0.01)。按照危险因素分组后发现吸烟组血清MMP
Keywords:
Carotid artery stenosis Matrix metalloproteinase-10 Risk factors
分类号:
R741
DOI:
10.3969/j.issn.1007-0478.2016.06.008
文献标志码:
A
摘要:
目的 探讨中老年颈动脉狭窄患者血清基质金属蛋白酶-10(MMP-10)的变化情况及其与主要危险因素、伴随症状、狭窄程度、狭窄部位和斑块性质之间的关系。方法 选择2014年3月～2016年2月在本院治疗的106例老年颈动脉狭窄患者作为病例组,随机选择同期在本院体检的80例无颈动脉狭窄的老年健康体检者作为对照组; 收集所有研究对象颈动脉超声检查及其他临床资料,并采集血清检测患者血清MMP-10水平。结果 病例组患者血清MMP-10水平显著高于对照组(p<0.01)。按照危险因素分组后发现吸烟组血清MMP-10水平高于非吸烟组(p<0.05); 糖尿病组MMP-10水平高于无糖尿病组(p<0.05)。病例组患者分组后发现症状性颈动脉狭窄患者血清MMP-10水平显著高于无症状组(p<0.05); 双侧颈动脉狭窄患者血清MMP-10水平显著高于单侧组(p<0.01); 不稳定性颈动脉粥样斑块患者血清MMP-10水平显著高于稳定性斑块组(p<0.05),且血清MMP-10水平随着狭窄程度升高而增加(p<0.01)。结论 中老年颈动脉狭窄患者血清MMP-10水平高于对照组,吸烟和糖尿病可增加血清MMP-10水平; 对于合并脑缺血症状、双侧颈动脉狭窄、不稳定性斑块及重度狭窄中老年患者MMP-10血清水平升高。
Abstract:
ObjectiveTo investigate the serum matrix metalloproteinase-10 levels(MMP-10)in the aged patients with carotid artery stenosis,evaluate the association between serum MMP-10 levels and main risk factors,accompany symptoms,degree of stenosis,narrow position and the nature of the plaque.Methods 16 elder patients with carotid artery stenosis admitted in our hospital from March 2014 to February 2016 were recruited as the patient group, and 80 healthy patients as the control group at the same time.Collect the carotid ultrasound examination results and other clinical data and detect serum MMP - 10 levels for statistical analysis.Results Patients with carotid artery stenosis had higher serum MMP-10 levels compared with control group(p<0.01).After grouped by risk factors, the MMP - 10 levels in the smoking group were higher than the non-smoking group(p<0.05); the diabetes group were higher than the non-diabetes group(p<0.05).After grouped by accompany symptoms, degree of stenosis, narrow position and the nature of the plaque, the MMP - 10 levels in patients with symptomatic carotid artery stenosis were higher than the non-symptomatic group(p<0.05); the bilateral carotid artery stenosis group were higher than the unilateral group(p<0.01); the unstable carotid atheromatous plaque group were higer than the stable group(p<0.05). And the serum MMP - 10 levels increased as the stenosis degree(p<0.01).Conclusion The aged with carotid artery stenosis have higher serum MMP-10 levels compared to the control group. Smoking and diabetes contribute to increasing the serum MMP-10 levels. For elder patients with stenosis, the serum MMP - 10 levels also increase when complicated by cerebral ischemia symptoms, bilateral carotid stenosis, unstable plaques and severe stenosis.

参考文献/References:

[1] Polak JF,Pencina MJ,O'leary DH,et al.Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis[J].Stroke,2011,42(11):3017-3021.
[2] Xiang J,Zhang T,Yang QW,et al.Carotid artery atherosclerosis is correlated with cognitive impairment in an elderly urban Chinese non-stroke population[J].J Clin Neurosci,2013,20(11):1571-1575.
[3] Yiqin Y,Meilin X,Jie X,et al.Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages[J].Inflammation,2009,32(4):233-241.
[4] Silvello D,Narvaes LB,Albuquerque LC,et al.Serum levels and polymorphisms of matrix metalloproteinases(MMPs)in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability[J].Biomarkers,2014,19(1):49-55.
[5] Montero I,Orbe J,Varo N,et al.C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis[J].J Am Coll Cardiol,2006,47(7):1369-1378.
[6] Johnson JL.Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability[J].Expert Rev Cardiovasc Ther,2007,5(2):265-282.
[7] Cavusoglu E,Marmur JD,Hegde S,et al.Relation of baseline plasma MMP-1 levels to long-term all-cause mortality in patients with known or suspected coronary artery disease referred for coronary angiography[J].Atherosclerosis,2015,239(1):268-275.
[8] 苏伟,高枫,龚少愚,等.动脉粥样硬化患者血液中基质金属蛋白酶-9及其抑制物-1的基因表达[J].苏州大学学报(医学版),2011,31(1):118-120, 123.
[9] 李凤,陈明,喻明,等.MMP-2基因多态性与动脉粥样硬化性脑梗死初发及复发相关性研究[J].中风与神经疾病杂志,2015,32(2):104-107.
[10] 徐晨凯,刘小伟,唐礼江,等.急性心肌梗死患者血清白三烯B_4和基质金属蛋白酶-9表达的变化及其意义[J].临床心血管病杂志,2015,31(5):536-538.
[11] Lvarez B,Ruiz C,Chacon P,et al.Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70%carotid artery stenosis[J].J Vasc Surg,2004,40(3):469-475.
[12] Orbe J,Montero I,Rodr guez JA,et al.Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis[J].J Thromb Haemost,2007,5(1):91-97.
[13] 王亚,丛树艳,黄奔鑫,等.基质金属蛋白酶-10血清水平与急性脑梗死的相关性分析[J].中华神经科杂志,2015,48(6):480-485.
[14] 朱峰,金笑平,黄米武,等.基质金属蛋白酶-10基因多态性与颈动脉斑块易损性的相关性[J].中华医学遗传学杂志,2013,30(6):711-715.

更新日期/Last Update: 2016-12-20