[1]曹峰,梅斌.丹红注射液治疗穿支动脉粥样硬化病的临床疗效观察[J].卒中与神经疾病杂志,2016,23(06):442-445.[doi:10.3969/j.issn.1007-0478.2016.06.014]
　Cao Feng,Mei Bin..The clinical effect of Danhong injection in the treatment of branch atheromatous disease[J].Stroke and Nervous Diseases,2016,23(06):442-445.[doi:10.3969/j.issn.1007-0478.2016.06.014]
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丹红注射液治疗穿支动脉粥样硬化病的临床疗效观察()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年06期
页码:
442-445
栏目:
论 著
出版日期:
2016-12-30

文章信息/Info

Title:
The clinical effect of Danhong injection in the treatment of branch atheromatous disease
文章编号:
1007-0478(2016)06-0442-04
作者:
曹峰; 梅斌
430071 武汉大学中南医院神经内科[曹峰 梅斌(通信作者)]
Author(s):
Cao Feng;  Mei Bin.
Department of Neurology,Zhongnan Hospital of Wuhan University,Wuhan 430071
关键词:
丹红注射液 NIHSS评分 C反应蛋白 肿瘤坏死因子-α
Keywords:
Danhong injection NIHSS score hs-CRP TNF-α
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.06.014
文献标志码:
A
摘要:
目的 观察丹红注射液治疗穿支动脉粥样硬化病(Branch Atheromatous Disease)患者的临床疗效以及血高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的水平变化。方法 选取本院住院诊断为穿支动脉粥样硬化病的患者67例,用随机数字法分为丹红组(34例)与对照组(33例),2组患者均给予抗血小板聚集、抗凝等常规治疗,丹红组在上述治疗的基础上加用丹红注射液静滴,连续治疗14 d,随访3个月,比较治疗前、后美国国立卫生研究院卒中量表(NIHSS)评分; 治疗前、后血hs-CRP、TNF-α水平。结果 与治疗前相比,2组患者治疗后第14 d、治疗后3个月的NIHSS评分均降低,2组患者第7 、14 d血hs-CRP、TNF-α水平均降低,丹红组较对照组变化更加显著,差异有统计学意义(P<0.05)。结论 在抗血小板聚集、抗凝治疗的基础上加用丹红注射液治疗穿支动脉粥样硬化病患者的临床疗效更好,远期生活质量更高,其机理可能与降低机体血hs-CRP、TNF-α水平,抑制炎症反应有关。
Abstract:
ObjectiveTo observe the clinical effect of the treatment using Danhong injection and serum high-sensitivity C-reactive protein(hs-CRP), tumor necrosis factor -α(TNF-α)in patients with Branch Atheromatous Disease.Methods 67 patients who were diagnosed as Branch Atheromatous Disease admitted in our hospital were selected and all of them were randomly divided into Danhong group(34 cases)and control group(33 cases),all the patients received treatment of antiplatelet,anticoagulation and other conventional treatment.Danhong intravenous injection were additional treatment in the Danhong group, continuous treatment for 14 days, followed up for 3 months, then compared NIHSS score、serum hs-CRP、TNF-α levels before and after treatment.Results Compared with prior treatment,after treatment for 14 days and three months,NIHSS scores were lower in both groups.the serum hs-CRP, TNF-α levels at 7th days and 14th days were lower, Danhong injection group changes more significantly than the control group, the difference had statistical significance(P<0.05).Conclusion Taking Danhong injection treatment based on the antiplatelet, anticoagulationtherapy, the goal of better clinical effect and long-term quality of life of patients with branch atheromatous disease will be achieved.reducing the serum hs- CRP and TNF-α levels and inhibiting inflammatory reaction may be the mechanism.

参考文献/References:

[1] 中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[2] 刘永刚,许云鹤,赵静,等.丁苯酞治疗分支动脉粥样硬化病脑梗死的临床疗效及安全性[J].脑与神经疾病杂志,2014,22(5):340-343.
[3] 肖章红,丁立东,柯开富.颈动脉粥样硬化斑块对脑梗死患者病情及其复发的影响[J].临床神经病学杂志,2015,04(4):269-272.
[4] 韩西娟,贾建平,孙永馨.腔隙性脑梗死与分支动脉粥样硬化病[J].临床神经病学杂志,2015,02(2):146-148.
[5] 孙龙飞.炎性信号通路在动脉粥样硬化中的机制与中医药干预作用研究进展[J].中国动脉硬化杂志,2015,23(11):1177-1181.
[6] 高磊,李卫华,谢强,等.阿托伐他汀对H型高血压患者血浆同型半胱氨酸及颈动脉粥样硬化程度的影响[J].中国动脉硬化杂志,2015,23(8):817-820.
[7] 张建平,严士海.二苯乙烯苷抑制apoE-/-小鼠动脉粥样硬化的机理研究[J].中华中医药学刊,2015,09(34):346-347.
[8] 张凯.动脉粥样硬化大血管和微血管病变的干预靶点研究[D].济南:山东大学,2014:27-29.
[9] 杨丽萍,张晓炜,张国华.等; 急性脑梗死患者血清YKL-40,hs-CRP水平与颈动脉粥样硬化斑块的相关性研究[J].中风与神经疾病杂志,2013,2(04):98-101.
[10] 谭昕.太加斌; 方袁媛等; 麝香保心丸治疗冠心病心绞痛及对患者血清炎症因子的影响[J].中华中医药学刊,2015,09(17):189-191.
[11] 许彩儒.丹参注射液治疗颈动脉粥样硬化的临床观察[J].广州医学院学报,2013,41(1):47-50.
[12] 王硕,何俗非,翟静波,等.丹红注射液药理作用及临床应用研究进展[J].中国中医药信息杂志,2014,03(3):128-131.
[13] 张利.丹参酮IIA及丹参酮IIA/丹酚酸B不同配比的混合物对大鼠脑缺血再灌注后炎性因子TNF-α和NF-K Bp65的影响[D].成都:成都中医药大学,2012:31-32.
[14] Chang JM,Hung LM,Chyan YJ,et al.Carthamus tinctorius Enhances the Antitumor Activity of Dendritic Cell Vaccines via Polarization toward Th1 Cytokines and Increase of Cytotoxic T Lymphocytes[J].Evid Based Complement Alternat Med,2011(1):274858.
[15] 管高峰.丹红注射液抗兔动脉粥样硬化的实验研究及其机制探讨[D].武汉:华中科技大学,2007:54-55.
[16] 王天虎.丹红注射液对急性脑梗死患者血清炎症因子的影响[J].中国实用神经疾病杂志,2011,14(3):44-46.
[17] 邹明智,王华,陈平,等.丹红注射液对急性脑梗死患者神经功能及血清hs-CRP、TNF-α和IL-6水平的影响[J].广东医学院学报,2014,32(4):452-454.

更新日期/Last Update: 2016-12-20