[1]刘超,吴海琴,王虎清,等.以脑梗死为首发症状的抗磷脂抗体综合征1例报道并文献回顾[J].卒中与神经疾病杂志,2016,23(06):446-449.[doi:10.3969/j.issn.1007-0478.2016.06.015]
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以脑梗死为首发症状的抗磷脂抗体综合征1例报道并文献回顾()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年06期
页码:
446-449
栏目:
论 著
出版日期:
2016-12-30

文章信息/Info

文章编号:
1007-0478(2016)06-0446-04
作者:
刘超吴海琴王虎清陈梦燚
710004 西安交通大学第二附属医院神经内科[刘超 吴海琴(通信作者)王虎清 陈梦燚]
关键词:
脑梗死 抗磷脂抗体综合征 抗磷脂抗体
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.06.015
文献标志码:
A
摘要:
目的 探讨抗磷脂抗体综合征(antiphospholipid antibodysyndrome, APS)合并脑梗死的病因、发病机制、诊断及治疗。方法 对本例APS患者的临床表现、神经影像学、实验室检查及治疗等情况加以分析,并结合国内外相关的文献对其病因、发病机制、诊断及治疗进行探讨。结果 APS的临床表现主要为血栓形成,可发生在全身任何组织器官,其中动脉血栓以脑动脉血栓形成较多见。该患者以急性脑梗死起病,脑血管造影见大脑中动脉及后动脉血栓形成,结合2次抗心磷脂抗体(anticardiolipinantibody, ACA)(间隔9个月)阳性及既往3次流产史,符合APS的诊断标准。结论 脑梗死是APS 的常见表现,尤其对于年轻女性发生脑梗死且合并不明原因流产时应考虑该病的可能性,应及时行抗磷脂抗体(antiphospholipidantibody, APL)检测,确诊后可给于抗凝、抗血小板聚集、激素等治疗。

参考文献/References:

[1] Wilson WA,Gharavi AE,Koike T,et al.International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop[J].Arthritis Rheum,1999,42(7):1309-1311.
[2] Miyakis S,Lockshin MD,Atsumi T,et al.International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome(APS)[J].J Thromb Haemost,2006,4(2):295-306.
[3] Asherson RA.New subsets of the antiphospholipid syndrome in 2006: "PRE-APS"(probable APS)and microangiopathic antiphospholipid syndromes("MAPS")[J].Autoimmun Rev,2006,6(2):76-80.
[4] Lim W.Antiphospholipid antibody syndrome[J].Hematology Am Soc Hematol Educ Program,2009,51(5):233-239.
[5] Rodrigues CE,Carvalho JF,Shoenfeld Y.Neurological manifestations of antiphospholipid syndrome[J].Eur J Clin Invest,2010,40(4):350-359.
[6] Chighizola CB,Andreoli L,De Jesus GR,et al.The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature[J].Lupus,2015,24(9):980-984.
[7] Galli M,Luciani D,Bertolini G,et al.Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature[J].Blood,2003,101(5):1827-1832.
[8] Brey RL,Muscal E,Chapman J.Antiphospholipid antibodies and the brain: a consensus report[J].Lupus,2011,20(2):153-157.
[9] Gris JC,Nobile B,Bouvier S.Neuropsychiatric presentations of antiphospholipid antibodies[J].Thromb Res,2015,135(Suppl 1):S56-S59.
[10] Tanne D,Katzav A,Beilin O,et al.Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome[J].Neurobiol Dis,2008,30(1):56-64.
[11] Ziporen L,Polak-Charcon S,Korczyn DA,et al.Neurological dysfunction associated with antiphospholipid syndrome: histopathological brain findings of thrombotic changes in a mouse model[J].Clin Dev Immunol,2004,11(1):67-75.
[12] Chapman J,Cohen-Armon M,Shoenfeld Y,et al.Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes[J].Lupus,1999,8(2):127-133.
[13] Katzav A,Pick CG,Korczyn AD,et al.Hyperactivity in a mouse model of the antiphospholipid syndrome[J].Lupus,2001,10(7):496-499.
[14] Ruiz-Irastorza G,Cuadrado MJ,Ruiz-Arruza I,et al.Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies[J].Lupus,2011,20(2):206-218.
[15] Danowski A,Rego J,Kakehasi AM,et al.Guidelines for the treatment of antiphospholipid syndrome[J].Rev Bras Reumatol,2013,53(2):184-192.

更新日期/Last Update: 2016-12-20