[1]段磊,高志强,李娟,等.经颅多普勒超声联合小剂量rt-PA静脉溶栓治疗急性脑梗死的临床研究[J].卒中与神经疾病杂志,2017,24(01):50-51+61.[doi:10.3969/j.issn.1007-0478.2017.01.013]
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经颅多普勒超声联合小剂量rt-PA静脉溶栓治疗急性脑梗死的临床研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第24卷
期数:
2017年01期
页码:
50-51+61
栏目:
论 著
出版日期:
2017-02-26

文章信息/Info

文章编号:
1007-0478(2017)01-0050-03
作者:
段磊; 高志强; 李娟; 高俊风; 刘玮
210011 南京医科大学第二附属医院神经内科
关键词:
急性脑梗死 TCD 重组组织型纤维酶原激活剂 静脉溶栓
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2017.01.013
摘要:
目的 观察经颅多普勒超声(TCD)联合小剂量重组组织型纤维酶原激活剂(rt-PA)治疗急性大脑中动脉闭塞性脑梗死的疗效。方法 采用随机分组方法,分为2组,2组患者在溶栓前均行TCD检查确定责任血管为大脑中动脉,设TCD联合小剂量rt-PA(0.6 mg/kg,最高总剂量50 mg)静脉溶栓组30例,在溶栓开始后TCD持续监测2 h,单纯rt-PA标准剂量0.9 mg/kg(最高总剂量90 mg)溶栓组30例,仅在溶栓前行TCD监测确定责任血管为大脑中动脉; 2组患者根据TCD血流速度及频谱形态判断血管再通情况,临床随访评定溶栓前后不同时间的NIHSS评分和Barthel指数。结果 TCD辅助小剂量rt-PA静脉溶栓组血管再通率为70%,明显高于对照组的30.0%,溶栓后2组NIHSS评分和Barthel指数评分存在显著差异。结论 TCD持续监测联合小剂量rt-PA静脉溶栓治疗急性脑梗死的临床疗效更佳。

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更新日期/Last Update: 2017-02-20