[1]刘欣,牛慧敏,张明明,等.血清YKL-40蛋白水平与颈动脉斑块内新生血管形成的关系[J].卒中与神经疾病杂志,2017,24(05):398-401+415.[doi:10.3969/j.issn.1007-0478.2017.05.004]
　Liu Xin*,Niu Huimin*,Zhang Mingming,et al.The level of serum YKL-40 protein and its association with neovascularization in carotid atherosclerotic plaque[J].Stroke and Nervous Diseases,2017,24(05):398-401+415.[doi:10.3969/j.issn.1007-0478.2017.05.004]
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血清YKL-40蛋白水平与颈动脉斑块内新生血管形成的关系()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第24卷
期数:
2017年05期
页码:
398-401+415
栏目:
论 著
出版日期:
2017-10-26

文章信息/Info

Title:
The level of serum YKL-40 protein and its association with neovascularization in carotid atherosclerotic plaque
文章编号:
1007-0478(2017)05-0398-05
作者:
刘欣; 牛慧敏; 张明明; 于明月; 高丽
050051 石家庄市,河北省人民医院超声科[刘欣 牛慧敏 于明月 高丽(通信作者)]; 检验科(张明明)
Author(s):
Liu Xin*; Niu Huimin*; Zhang Mingming; et al.
*Department of Ultrasound,HeBei General Hospital,Shijiazhuang 05005
关键词:
YKL-40蛋白 颈动脉硬化 斑块 新生血管 超微血管成像 血清标志物
Keywords:
YKL-40 protein Carotid atherosclerosis Plaque Neovascularization Super microvascular imaging(SMI)Serum biomarker
分类号:
R543.5
DOI:
10.3969/j.issn.1007-0478.2017.05.004
摘要:
目的 探讨血清YKL-40蛋白水平与颈动脉斑块内新生血管形成的关系。方法 收集2015年1月～2016年12月本院超声科首次发现有颈动脉斑块者575例为研究组,以同期无动脉斑块者500例为对照组; 应用超微血管成像(SMI)技术判断斑块内新生血管分级,并检测研究对象的血清YKL-40蛋白、血脂、炎性因子TNF-α、hsCRP、IL-6等指标水平。结果 ①与对照组比较,研究组TC、TG、LDLC水平明显升高,HDLC明显降低(P均<0.05); ②研究组的IL-6、TNF-α、hsCRP、Lp-PLA2、YKL-40蛋白水平与对照组存在明显差异(P<0.05); ③按SMI分级将研究组患者分为4组,4组患者的YKL-40蛋白、IL-6、TNF-α、hsCRP、Lp-PLA2、血脂水平存在明显差异(P均<0.05); ④YKL-40蛋白与炎性因子及血脂指标水平存在相关性(P均<0.05)。结论 血清YKL-40蛋白水平与颈动脉斑块内新生血管形成的严重程度有关,检测YKL-40蛋白水平对判断斑块的稳定性有益。
Abstract:
ObjectiveTo study the relationship between serum YKL-40 protein level and neovascularization in carotid atherosclerotic plaque.Methods 575 cases with carotid atherosclerotic plaque from 2015.1 to 2016.12 in ultrasound department of our hospital were recruited as research group,500 cases without carotid atherosclerotic plaque during the same period as control group. Degree of neovascularization in carotid atherosclerotic plaque was assessed with SMI technique.Serum YKL-40,lipid and inflammatory factors TNF-α,hsCRP,IL-6 level were detected.Results The serum levels of TC,TG,LDL-C were higher in research group than those control group,while level of HDL-C was lower than that of control group(P<0.05).There were significant differences for YKL-40,IL-6,TNF-α,hsCRP,Lp-PLA2 between research group and control group(P<0.05).The levels of YKL-40,IL-6,TNF-α,hsCRP,Lp-PLA2 and lipids were significantly differently according to result of MSI detection.YKL-40 level was related to inflammatory factors,lipids(P<0.05).Conclusion There was closely association between serum YKL-40 and neovascularization in carotid atherosclerotic plaque,and it's valuable to evaluate stability of carotid atherosclerotic plaque by testing level of YKL-40.

参考文献/References:

[1] Liu AY,Yu ZQ,Wang N,et al.Carotid atherosclerosis is associated with hypertension in a hospital-based retrospective cohort[J].Int J Clin Exp Med,2015,8(11):21932-21938.
[2] Liu J,Kerwin WS,Caldwell JH,et al.High resolution FDG-microPET of carotid atherosclerosis:plaque components underlying enhanced FDG uptake[J].International Journal of Cardiovascular Imaging,2016,32(1,SI):145-152.
[3] Kobayashi T,Yokokawa H,Fujibayashi K,et al.Association between high cystatin C levels and carotid atherosclerosis[J].World J Cardiol,2017,9(2):174-181.
[4] Boesen ME,Singh D,Menon BK,et al.A systematic literature review of the effect of carotid atherosclerosis on local vessel stiffness and elasticity[J].Atherosclerosis,2015,243(1):211-222.
[5] Jin Y,Cao JN,Wang CX,et al.High serum YKL-40 level positively correlates with coronary artery disease[J].Biomark Med,2017,11(2):133-139.
[6] Schernthaner GH,Hoebaus C,Brix J.YKL-40 and its complex association with metabolic syndrome,obesity,and cardiovascular disease[J].ANATOLIAN JOURNAL OF CARDIOLOGY,2016,16(12):959-960.
[7] 高丽,薛红元,叶玉泉,等.超微血管成像及超声造影评价不同厚度颈动脉斑块内新生血管的研究[J].中华超声影像学杂志,2016,25(8):731-732.
[8] Zingg S,Collet TH,Locatelli I,et al.Associations between cardiovascular risk factors,inflammation,and progression of carotid atherosclerosis among smokers[J].Nicotine & Tobacco Research,2016,18(6):1533-1538.
[9] Hassan KM,Verma A,Prakash S,et al.Prevalence and association of lifestyle factors with extracranial carotid atherosclerosis in non-cardioembolic anterior circulation strokes in adult males less than 50 years:One year cross-sectional study[J].Ann Indian Acad Neurol,2013,16(4):516-520.
[10] Yahagi K,Kolodgie FD,Lutter C,et al.Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus[J].Arterioscler Thromb Vasc Biol,2017,37(2):191-204.
[11] Garg PK,Mcclelland RL,Jenny NS,et al.Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort:The multi ethnic study of atherosclerosis[J].Atherosclerosis,2015,241(1):176-182.
[12] Leonardi S,Parisi GF,Capizzi AA,et al.YKL-40 as marker of severe lung disease in cystic fibrosis patients[J].Journal of Cystic Fibrosis,2016,15(5):583-586.
[13] Chen HT,Zheng JM,Zhang YZ,et al.Overexpression of YKL-40 predicts poor prognosis in patients undergoing curative resection of pancreatic cancer[J].Pancreas,2017,46(3):323-334.
[14] Wan GX,Xiang LC,Sun XE,et al.Elevated YKL-40 expression is associated with a poor prognosis in breast cancer patients[J].Oncotarget,2017,8(3):5382-5391.

备注/Memo

备注/Memo:
基金项目:河北省重点课题计划(20150137)
更新日期/Last Update: 2017-10-20