[1]危薇,罗华,汪静秋.颈内动脉重度狭窄或闭塞患者脑血管反应性和认知功能的相关性研究[J].卒中与神经疾病杂志,2017,24(05):407-409+419.[doi:10.3969/j.issn.1007-0478.2017.05.006]
　Wei Wei,Luo Hua,Wang Jingqiu..The study on relationship between cerebral vascular reactivity and cognitive function in patients with severe stenosis or occlusion of internal carotid artery[J].Stroke and Nervous Diseases,2017,24(05):407-409+419.[doi:10.3969/j.issn.1007-0478.2017.05.006]
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颈内动脉重度狭窄或闭塞患者脑血管反应性和认知功能的相关性研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第24卷
期数:
2017年05期
页码:
407-409+419
栏目:
论 著
出版日期:
2017-10-26

文章信息/Info

Title:
The study on relationship between cerebral vascular reactivity and cognitive function in patients with severe stenosis or occlusion of internal carotid artery
文章编号:
1007-0478(2017)05-0407-04
作者:
危薇; 罗华; 汪静秋
646000 四川泸州西南医科大学附属医院神经内科
Author(s):
Wei Wei; Luo Hua; Wang Jingqiu.
Department of Neurology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000
关键词:
颈动脉狭窄 脑血管反应性 认知功能损害
Keywords:
Carotid Stenosis Cerebral vascular reactivity Cognitive impairment
分类号:
R543.5
DOI:
10.3969/j.issn.1007-0478.2017.05.006
摘要:
目的 探讨不同部位颈内动脉重度狭窄或闭塞患者的脑血管反应性(cerebral vascular reactivity,CVR)和认知功能改变的特点及两者的相关性。方法 选取颈内动脉重度狭窄或闭塞患者58例为病例组,按照狭窄部位分为左侧狭窄组、右侧狭窄组和双侧狭窄组,另选取正常人20例为对照组,采用经颅多普勒超声(transcranial Doppler,TCD)结合屏气试验分别检测各组屏气指数(breath-holding index,BHI),用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评估各组的认知功能。结果 病例组的BHI均低于对照组,双侧狭窄组低于左、右侧狭窄组; 右侧狭窄组的MoCA视空间/执行得分低于左侧狭窄组和对照组,左侧狭窄组的延迟记忆得分低于右侧狭窄组和对照组,双侧狭窄组的视空间/执行、延迟记忆和语言功能得分均低于对照组,且MoCA总分低于左、右侧狭窄组; 病例组内的BHI与MoCA总分呈正相关(r=0.411,0.474,0.868,P<0.05)。结论(1)颈内动脉重度狭窄或闭塞患者的BHI明显降低,认知功能也有不同程度损害;(2)颈内动脉重度狭窄或闭塞患者的BHI和MoCA总分有明显关系,将两者结合可更全面地反映认知功能。
Abstract:
ObjectiveTo analyze the change of characteristics of cerebral vascular reactivity(CVR),cognitive function and their relativity.Methods 58 patients with severe stenosis or occlusion of the internal carotid artery were selected as case group,and were divided into left stenosis group,right stenosis group and bilateral stenosis group,while 20 controls of them were enrolled.Using transcranial Doppler(TCD)and breath-holding technique to observe breath-holding index(BHI)and Montreal Cognitive Assessment(MoCA)to assess cognitive function of each group.Results The BHI in the case group was lower than that in controls,and the BHI in bilateral stenosis group was lower than left and right stenosis group.The scores of visual space and executive of MoCA in right stenosis group were lower than left stenosis group and control group,and the delayed recall scores in left stenosis group were lower than right stenosis group and control group.The scores of visual space and executive,delayed recall,and language in bilateral stenosis group were all lower than the control group,while the total scores of MoCA in bilateral stenosis group were lower than left and right stenosis group.The BHI in the case group was positively correlated with the total scores of MoCA(r=0.411,0.474,0.868,P<0.05).Conclusion(1)The BHI in patients with severe stenosis or occlusion of the internal carotid artery was significantly lower,and the cognitive function impaired to different degrees.(2)The BHI in patients with severe stenosis or occlusion of the internal carotid artery was apparently correlated with the total scores of MoCA,and the combination of the two could reflect the cognitive function more comprehensively.

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备注/Memo

备注/Memo:
基金项目:泸州医学院附属医院青年基金项目(2015-QS-034)
更新日期/Last Update: 2017-10-20