[1]范红燕,司江华,彭小兰,等.甘肃地区汉族和回族脑出血患者α-内收蛋白基因rs4963多态性分析[J].卒中与神经疾病杂志,2017,24(05):436-438.[doi:10.3969/j.issn.1007-0478.2017.05.013]
　Fan Hongyan*,Si Jianghua,Peng Xiaolan,et al.The analysis of ADD1 gene rs4963 polymorphisms between Hanzu and Huizu populations with cerebral hemorrhage in Gansu[J].Stroke and Nervous Diseases,2017,24(05):436-438.[doi:10.3969/j.issn.1007-0478.2017.05.013]
点击复制

甘肃地区汉族和回族脑出血患者α-内收蛋白基因rs4963多态性分析()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第24卷
期数:
2017年05期
页码:
436-438
栏目:
论 著
出版日期:
2017-10-26

文章信息/Info

Title:
The analysis of ADD1 gene rs4963 polymorphisms between Hanzu and Huizu populations with cerebral hemorrhage in Gansu
文章编号:
1007-0478(2017)05-0436-03
作者:
范红燕; 司江华; 彭小兰; 严雯; 谢守嫔; 范彩霞
730050 兰州市第一人民医院干部病房(范红燕),神经内科[司江华(通信作者)彭小兰 严雯 谢守嫔 范彩霞]
Author(s):
Fan Hongyan*; Si Jianghua; Peng Xiaolan; et al.
*Department of Gerontology,The First People's Hospital of Lanzhou City,Lanzhou 730050
关键词:
脑出血 α-内收蛋白基因 甘肃地区 汉族 回族
Keywords:
Cerebral hemorrhage ADD1 gene Gansu Hanzu Huizu
分类号:
R743.34
DOI:
10.3969/j.issn.1007-0478.2017.05.013
摘要:
目的 分析甘肃地区汉族和回族脑出血患者α-内收蛋白基因rs4963多态性的分布情况。方法 对甘肃地区汉族和回族脑出血患者各176例应用血液基因组DNA提取试剂盒方法检测α-内收蛋白基因rs4963多态性,比较rs4963多态性的分布差异。结果 汉族组和回族组α-内收蛋白基因rs4963基因型分布、等位基因频率均无明显差异(P>0.05); 按性别分层后汉族组与回族组基因型分布和等位基因频率仍均无明显差异(P>0.05)。结论 α-内收蛋白基因rs4963多态性在甘肃地区汉族和回族脑出血人群中无民族差异。
Abstract:
ObjectiveTo investigate the genetic polymorphisms in the ADD1 gene rs4963(C/G)polymorphisms in patients with cerebral hemorrhage(CH)from Han nationality and Hui minority populations in Gansu province,China.Methods A total of 352 subjects(176 Hanzu and 176 Huizu patients)were collected from Gansu residents.The DNA was extracted by blood genomic DNA extraction kit,and the tag SNP rs4963 polymorphisms of ADD1 gene was detected by Tm -shift genotyping method for all subjects.Results The results showed the genotype and allele frequency of rs4963 were not significantly different between Hanzu and Huizu CH patients(P>0.05).The stratification analysis of gender indicated that the genotype and allele frequency of rs4963 were not significantly different between Hanzu and Huizu CH patients(P>0.05).Conclusion The genetic polymorphisms in ADD1 gene rs4963 were not significantly different between Hanzu and Huizu CH patients in Gansu Province,China.

参考文献/References:

[1] Catto AJ.Genetic aspects of the hemostatic system in cerebrovascular disease[J].Neurology,2001,57(5,2):S24-S30.
[2] Srivastava Kamna,Sundriyal Ruchi,Meena C,et al.Association of angiotensin converting enzyme(insertion/deletion)gene polymorphism with essential hypertension in northern Indian subjects[J].Genet Test Mol Biomarkers,2012,16(3):174-177.
[3] Zhang na,Ji dan,Fei juan,et al.Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population[J].Biomed Res Int,2013:451094.
[4] Reddy K,Labhasetwar Vinod.Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury[J].FASEB J,2009,23(5):1384-1395.
[5] Ramu P,Umamaheswaran G,Shewade DG,et al.Gly460Trp polymorphism of the ADD1 gene and essential hypertension in an Indian population: A meta-analysis on hypertension risk[J].Indian J Hum Genet,2010,16(1):8-15.
[6] 李哲,王丹,李翠丽,等.山西地区血管紧张素原基因和α-内收蛋白基因多态性与原发性高血压的相关性研究[J].中华疾病控制杂志,2011,15(9):740-744.
[7] 中华医学会神经病学分会.全国第四届脑血管病学术会议标准(1995)[J].中华神经科杂志,1996,29(6):376-381.
[8] 龚敏莉,郝玲妹,范瑞,等.α-内收蛋白基因rs4963多态性与原发性高血压的关联研究[J].中国慢性病预防与控制,2015,23(9):667-671.
[9] Watanabe Yumiko,Metoki Hirohito,Ohkubo Takayoshi,et al.Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study[J].Hypertens Res,2010,33(2):129-134.
[10] 杨艳,肖玉娴.高血压脑出血的危险因素分析及治疗体会[J].中国实用神经疾病杂志,2015,18(19):72-73,74.

备注/Memo

备注/Memo:
基金项目:兰州市卫生科技发展计划项目(LZWSKY2014-2-01)
更新日期/Last Update: 2017-10-20