[1]董涛,王大堃,张文岐,等.血浆和肽素及S100B与脑外伤患者病情及预后的相关性研究[J].卒中与神经疾病杂志,2018,25(02):179-182.[doi:10.3969/j.issn.1007-0478.2018.02.014]
　Dong Tao*,Wang Dakun,Zhang Wenqi*,et al.The correlation study between plasma peptide,S100B levels and evaluating disease conditions,prognosis of patients with traumatic brain injury[J].Stroke and Nervous Diseases,2018,25(02):179-182.[doi:10.3969/j.issn.1007-0478.2018.02.014]
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血浆和肽素及S100B与脑外伤患者病情及预后的相关性研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第25卷
期数:
2018年02期
页码:
179-182
栏目:
论 著
出版日期:
2018-04-26

文章信息/Info

Title:
The correlation study between plasma peptide,S100B levels and evaluating disease conditions,prognosis of patients with traumatic brain injury
文章编号:
1007-0478(2018)02-0179-04
作者:
董涛; 王大堃; 张文岐; 王江峰; 刘金道; 陈琛
712000 陕西省咸阳市陕西中医药大学第二附属医院神经外科(董涛 张文岐 王江峰 刘金道 陈琛),影像科[王大堃(通信作者)]
Author(s):
Dong Tao*; Wang Dakun; Zhang Wenqi*; et al.
*Department of Neurosurgery,The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medicine,Shanxi Xianyang 712000
关键词:
和肽素 S100B 脑外伤 预后
Keywords:
Peptide S100B Traumatic brain injury Prognosis
分类号:
R651.1+5
DOI:
10.3969/j.issn.1007-0478.2018.02.014
文献标志码:
A
摘要:
目的 探讨和肽素和S100B在脑外伤患者血浆中的变化情况及与患者预后的关系。方法 以118例脑外伤患者和60例健康人为研究对象,收集患者发病治疗前、治疗后7 d和90 d的血浆并对血浆中和肽素和S100B水平进行检测,记录一般资料、病史、临床资料以及影像学特点等指标,采用格拉斯哥(Glasgow coma Scale,GCS)评分对患者入院时治疗前及治疗后90 d情况进行评估,根据患者发病90 d的GCS评分将患者进一步分组,分析血浆和肽素和S100B水平与预后的关系。结果 脑外伤患者血浆中和肽素和S100B水平显著高于健康对照组(P<0.05); 脑外伤患者血浆中和肽素和S100B水平随发病时间逐渐降低; 患者治疗前血浆中和肽素和S100B水平与患者脑梗死体积及入院时的GCS评分呈负相关,与患者治疗后90 d的GCS评分呈负相关; 患者治疗后90 d预后良好患者的血浆中和肽素和S100B水平显著低于预后不良患者(P<0.001)。结论 在脑外伤患者中血浆中和肽素和S100B表达水平明显升高,并且与患者病情严重程度呈负相关,且可以预测患者治疗后90 d的预后情况。
Abstract:
ObjectiveTo determine the correlation between plasma peptide,S100B and outcome of traumatic brain injury.Methods 118 traumatic brain injury patients(the observation group)and 60 health volunteers(the control group)were recruited.The information of general information,history,clinical data and imaging characteristics were collected.The levels of peptide,S100B in plasma were detected and the GCS at admission and 90th day were collected.The patients were divided into 2 groups according to the GCS score at 90 th day,the relationship between peptide,S100B in plasma and outcome of traumatic brain injury was analyzed.Results The levels of plasma peptide and S100B were obviously higher in the observation group than those in the control group(P<0.05); The levels of plasma peptide,S100B of patients decreased with the time.The levels of plasma peptide,S100B in patients were negatively correlated with the GCS score at admission,and which was negatively correlated with the GCS score at 90th day,the levels of plasma peptide,S100B in patients with good outcome were lower than those in patients with bad outcomes(P<0.001).Conclusion The level of plasma peptide and S100B in traumatic brain injury patients was significantly increased and was negatively correlated with the severity of the disease,and which also could predict the prognosis of 90 days.

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更新日期/Last Update: 2018-04-20