参考文献/References:
[1] Mozaffarian D,Benjamin EJ,Go AS,et al.Heart disease and stroke statistics--2015 update:a report from the American Heart Association[J].Circulation,2015,131(4):e29-322.
[2] Kim AS,Johnston SC.Temporal and geographic trends in the global stroke epidemic[J].Stroke:a journal of celebral cirallation,2013,44(1):123-125.
[3] Cheng Q,Zhang Z,Zhang S,et al.Human umbilical cord mesenchymal stem cells protect against ischemic brain injury in mouse by regulating peripheral immunoinflammation[J].Brain Res,2015,1594(1):293-304.
[4] Banerjee S,Williamson D,Habib N,et al.Human stem cell therapy in ischaemic stroke:a review[J].Age Ageing,2011,40(1):7-13.
[5] Li Y,Hu G,Cheng Q.Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke:perspectives and challenges[J].Frontiers of medicine,2015,9(1):20-29.
[6] Chelluboina B,Klopfenstein JD,Pinson DM,et al.Stem cell treatment after cerebral ischemia regulates the gene expression of apoptotic molecules[J].Neurochem Res,2014,39(8):1511-1521.
[7] Park HW,Moon HE,Kim H,et al.Human umbilical cord Blood-Derived mesenchymal stem cells improve functional recovery through thrombospondin1,pantraxin3,and vascular endothelial growth factor in the ischemic rat brain[J].J Neurosci Res,2015,93(12):1814-1825.
[8] Turner RC,Dodson SC,Rosen CL,et al.The science of cerebral ischemia and the quest for neuroprotection:navigating past failure to future success A review[J].J Neurosurg,2013,118(5):1072-1085.
[9] Zhang L,Li Y,Zhang CL,et al.Delayed administration of human umbilical Tissue-Derived cells improved neurological functional recovery in a rodent model of focal ischemia[J].Stroke,2011,42(5):1437-1444.
[10] Sinden JD,Vishnubhatla I,Muir KW.Chapter 8-prospects for stem cell-derived therapy in stroke[J].Prog Brain Res,2012,201(201):119-167.
[11] Buonocore G,Turrisi G,Kramer BW,et al.New pharmacological approaches in infants with Hypoxic-Ischemic encephalopathy[J].Curr Pharm Des,2012,18(21):3086-3100.
[12] Veeravalli KK,Dasari VR,Fassett D,et al.Human umbilical cord Blood-Derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice[J].Stem Cells Dev,2011,20(5):881-891.
[13] Chao YH,Wu HP,Chan CK,et al.Umbilical Cord-Derived mesenchymal stem cells for hematopoietic stem cell transplantation[J].Journal of Biomedicine and Biotechnology,2015,2012(3):759503.
[14] Dehua,Changhui,Wang,et al.Human amnion tissue injected with human umbilical cord mesenchymal stem cells repairs damaged sciatic nerves in rats[J].Neural Regeneration Research,2012,7(23):1771-1778.
[15] Liu R,Zhang Z,Lu ZJ,et al.Human umbilical cord stem cells ameliorate experimental autoimmune encephalomyelitis by regulating immunoinflammation and remyelination[J].Stem Cells Dev,2013,22(7):1053-1062.
[16] Liu GY,Xu Y,Li Y,et al.Secreted galectin-3 as a possible biomarker for the immunomodulatory potential of human umbilical cord mesenchymal stromal cells[J].Cytotherapy,2013,15(10):1208.
[17] Hsieh JY,Wang HW,Chang SJ,et al.Mesenchymal stem cells from human umbilical cord Express preferentially secreted factors related to neuroprotection,neurogenesis,and angiogenesis[J].PLoS One,2013,8(8):e72604.
[18] Petrova ES.The use of stem cells to stimulate regeneration of damaged nerve[J].Tsitologiia,2012,54(7):525.
[19] Aronin CP,Tuan RS.Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells[J].Birth Defects Res C Embryo Today,2010,90(1):67-74.
[20] Zhao QC,Hu JX,Xiang J,et al.Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke[J].Brain Res,2015,1624(8):489-496.
[21] Lees JS,Sena ES,Egan KJ,et al.Stem cell-based therapy for experimental stroke:A systematic review and meta-analysis[J].International Journal of Stroke,2012,7(7):582-588.
[22] Singhapol C,Pal D,Czapiewski R,et al.Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis[J].PLoS One,2013,8(1):e52989.
[23] Li J,Tang B,Yi Q,et al.Telomerase reverse transcriptase:A novel neuroprotective mechanism involved in neonatal hypoxic-ischemic brain injury[J].Int J Dev Neurosci,2011,29(8):867.
[24] Kovalenko OA,Caron MJ,Ulema PA,et al.A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction[J].Aging Cell,2010,9(2):203-219.
[25] Lee J,Sung YH,Cheong C,et al.TERT promotes cellular and organismal survival independently of telomerase activity[J].Oncogene,2008,27(26):3754-3760.
[26] Ding D,Zhou J,Wang M,et al.Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer[J].FEBS J,2013,280(14):3205-3211.
[27] Zhao FY,Qu Y,Liu HT,et al.Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF:A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage[J].International Journal of Developmental Neuroscience,2014,38(2014):147-154.
[28] Qu Y,Duan ZJ,Zhao FY,et al.Telomerase reverse transcriptase upregulation attenuates astrocyte proliferation and promotes neuronal survival in the Hypoxic-Ischemic rat brain[J].Stroke,2011,42(12):U325-3542.
[29] Pikula A,Beiser AS,Chen TC,et al.Serum Brain-Derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury framingham study[J].Stroke,2013,44(10):2768-2775.
[30] Jianxin,Zhao,Huazhou,et al.Effect of electroacupuncture on brain-derived neurotrophic factor mRNA expression in mouse hippocampus following cerebral ischemia-reperfusion injury[J].Journal of Traditional Chinese Medicine,2013,33(2):253-257.
[31] Amantea D,Micieli G,Tassorelli C,et al.Rational modulation of the innate immune system for neuroprotection in ischemic stroke[J].Front Neurosci,2015,9(9):147.
[32] Wang S,Cheng HB,Dai GH,et al.Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury[J].Brain Res,2013,1532(1):76-84.
[33] Lee J,Jo YS,Sung YH,et al.Telomerase deficiency affects normal brain functions in mice[J].Neurochem Res,2010,35(2):211-218.
[34] Bressler J,Franceschini N,Demerath EW,et al.Sequence variation in telomerase reverse transcriptase(TERT)as a determinant of risk of cardiovascular disease:the Atherosclerosis Risk in Communities(ARIC)study[J].BMC Med Genet,2015,16(1):1-10.