[1]朱和材 文奎 王超.原发性脑出血后肾功能损害与脑小血管病变的关系[J].卒中与神经疾病杂志,2019,26(02):174-177.[doi:10.3969/j.issn.1007-0478.2019.02.010]
　Zhu Hecai,Wen Kui,Wang Chao..The relationship between renal dysfunction and cerebral small vessel disease after primary intracerebral hemorrhage[J].Stroke and Nervous Diseases,2019,26(02):174-177.[doi:10.3969/j.issn.1007-0478.2019.02.010]
点击复制

原发性脑出血后肾功能损害与脑小血管病变的关系()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第26卷
期数:
2019年02期
页码:
174-177
栏目:
论 著
出版日期:
2019-04-20

文章信息/Info

Title:
The relationship between renal dysfunction and cerebral small vessel disease after primary intracerebral hemorrhage
文章编号:
1007-0478(2019)02-0174-04
作者:
朱和材 文奎 王超
636000 四川省巴中市中医院(巴州区人民医院)
Author(s):
Zhu Hecai; Wen Kui; Wang Chao.
Department of Neurosurgery,Bazhong City Hospital of Traditional Chinese Medicine(People's Hospital of Bazhou District),Bazhong City,Sichuan Province 636000
关键词:
原发性脑出血;  肾功能损害;  血管病变
Keywords:
Primary cerebral hemorrhage Renal impairment Vascular disease
分类号:
R743.34
DOI:
10.3969/j.issn.1007-0478.2019.02.010
文献标志码:
A
摘要:
目的 探讨原发性脑出血患者肾功能损害与脑小血管病变的关系。方法 自2017年1月-2018年3月回顾性收集本院收治的原发性脑出血患者134例,根据患者是否出现肾功能损害将患者分为观察组(合并肾功能损伤,n=52)和对照组(不存在肾功能损伤,n=82),观察2组患者的预后和脑小血管病变情况。结果 与对照组比较,观察组患者腔隙性脑梗死和白质弥漫性疏松发生率更高[(40.38% vs.23.17%,P=0.034)和(34.62% vs.18.29%,P=0.033)]; 与对照组比较,观察组患者FA值显著降低(0.40±0.12 vs.0.46±0.14,P=0.012); ADC值显著增高(2.78±0.23 vs.2.56±0.28,P=0.000); 观察组患者认知功能显著低于对照组(21.46±4.28 vs.23.39±3.69,P=0.006); 观察组患者健康相关的生存质量(SF-36)显著低于对照组(66.75±14.57 vs.72.28±10.95,P=0.014)。结论 原发性脑出血患者肾功能损伤较为常见,其可能与患者脑小血管病变有关。
Abstract:
ObjectiveTo investigate the relationship between renal dysfunction and cerebral small vessel disease in patients with primary cerebral hemorrhage.Methods From January 2017 to March 2018,134 patients with primary cerebral hemorrhage in our hospital were retrospectively collected.According to whether the patients had renal impairment,the patients were divided into the observation group(combined with renal impairment,n=52)and the control group(no renal impairment,n=82).The prognosis and cerebral small vessel lesions of the two groups were observed.Results When compared with the control group,the incidence of lacunar infarction and leukoaraiosis in the observation group was higher [(40.38% vs.23.17%,P = 0.034)and(34.62% vs.18.29%,P = 0.033)].When compared with the control group,the FA value of the observation group was significantly lower(0.40±0.12 vs.0.46±0.14,P=0.012),and the ADC value was significantly higher(2.78±0.23 vs.2.56±0.28,P=0.000).The cognitive function of the observation group was significantly lower than that of the control group(21.46±4.28 vs.23.39±3.69,P=0.006).The health-related quality of life(SF-36)of the observation group was significantly lower than that of the control group(66.75±14.57 vs.72.28±10.95,P=0.014).Conclusion The renal injury was common in patients with primary intracerebral hemorrhage,and might be associated with cerebral small vessel disease.

参考文献/References:

[1] Xu M,Zhang S,Liu J,et al.Kidney dysfunction is associated with a high burden of cerebral small vessel disease in primary intracerebral hemorrhage[J].Current Neurovascular Research,2018,15(1):39-46.
[2] Roh D,Sun C-h,Schmidt JM,et al.Primary intracerebral hemorrhage:a closer look at hypertension and cerebral amyloid angiopathy[J].Neurocritical Care,2018,29(1):77-83.
[3] Niesen W D,Schlaeger A,Reinhard M,et al.Transcranial sonography to differentiate primary intracerebral hemorrhage from cerebral infarction with hemorrhagic transformation[J].Journal of Neuroimaging,2018,28(4):370-373.
[4] Tsai HH,Tsai LK,Chen Ya-fang,et al.Correlation of cerebral microbleed distribution to amyloid burden in patients with primary intracerebral hemorrhage[J].Scientific Reports,2017,7(2):44715-44719.
[5] Xu Xu-hua,Ye Xiang-hua,Cai Jin-song,et al.Association of renal dysfunction with remote Diffusion-Weighted imaging lesions and total burden o cerebral small vessel disease in patients with primary intracerebral hemorrhage[J].Frontiers in Aging Neuroscience,2018,10(2):171-177.
[6] Cai J,Jy J,Kim J,et al.Comparative effects of plant oils on the cerebral hemorrhage in stroke-prone spontaneously hypertensive rats[J].Nutritional Neuroscience,2016,19(7):318-326.
[7] Zaki GM,Srinivasan VM,Wagner K,et al.Cognitive sequelae of subarachnoid hemorrhage,cerebral aneurysm treatment,and neuropsychological assessment[J].World Neurosurgery,2018,12(3):783-788.
[8] Banerjee G,Wilson D,Ambler G,et al.Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy[J].Stroke,2018,49(1):40.
[9] Hayman EG,Wessell A,Gerzanich V,et al.Mechanisms of global cerebral edema formation in aneurysmal subarachnoid hemorrhage[J].Neurocritical Care,2017,26(2):301-310.
[10] Zhang Li-tang,Zhang Su-xia,Wu Song-di.Electroencephalogram analysis:an early diagnostic method for assessing cognitive impairment after cerebral hemorrhage[J].Clinical EEG and Neuroscience,2014,45(2):92-97.
[11] Wu Xian,Lv Yang-ge,Du Yi-feng,et al.Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment,neuroinflammation,apoptosis,and synaptic dysfunction in mice[J].Progress in Neuro-Psychopharmacology & Biological Psychiatry,2019,88(23):360-374.
[12] Lukaszyk E,Bien-Barkowska K,Bien B.Cognitive functioning of geriatric patients:is hypovitaminosis D the next marker of cognitive dysfunction and dementia?[J].Nutrients,2018,10(8):881-887.
[13] Liang Peng,Shan Wei-ran,Zuo Zhi-yi.Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice[J].Journal of Neuroinflammation,2018,15(1):235-241.
[14] 施媛.脑白质疏松症与脑出血患者认知功能障碍的关联分析[J].中国医药指南,2014,12(34):68-69.
[15] 何剑波,李会琪,张恒,等.脑梗死患者认知功能障碍与脑白质疏松症相关性分析[J].陕西医学杂志,2013,42(10):1366-1368.
[16] 姜容.单病灶脑出血患者认知功能的LOTCA量表评定研究[D].昆明医科大学,2014.
[17] Kim SH,Shin DW,Yun JM,et al.Kidney dysfunction and cerebral microbleeds in neurologically healthy adults[J].PLOS One,2017,12(2):2210-2214.
[18] Peng Qing,Sun Wei,Liu Wen-hong,et al.Longitudinal relationship between chronic kidney disease and distribution of cerebral microbleeds in patients with ischemic stroke[J].Journal of the Neurological Sciences,2016,362(12):1-6.
[19] Lin SY,Tang Sun-chun,Shen L J,et al.Prothrombin complex concentrate(beriplex P/N)-related renal and cerebral infarctions in a patient with warfarin-associated intracerebral hemorrhage[J].Journal of Stroke & Cerebrovascular Diseases,2015,24(1):E15-E16.
[20] Koide M,Kato M,Usui K,et al.Successful complete revascularization with PCI using Super-Low volume of contrast medium in a patient with Three-Vessel disease including 2 chronic total occlusions ``with severe renal dysfunction[J].International Heart Journal,2017,58(4):624-628.
[21] Russell JC,Kelly SE,Diane A,et al.Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2010,299(2):G507-G516.
[22] Heidari R,Ahmadi A,Mohammadi H,et al.Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance[J].Biomedicine & Pharmacotherapy,2018,107(23):834-840.
[23] Jing Wang-hui,Nunes AC,Farzaneh T,et al.Phosphate binder,ferric citrate,attenuates anemia,renal dysfunction,oxidative stress,inflammation,and fibrosis in 5/6 nephrectomized CKD rats[J].Journal of Pharmacology and Experimental Therapeutics,2018,367(1):129-137.
[24] Lv Dao-yuan,Zhou Qin,Xia Yu-e,et al.The association between oxidative stress alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 signaling pathway activation and chronic renal allograft dysfunction improvement[J].Kidney & Blood Pressure Research,2018,43(1):191-205.
[25] He Ping,Li Zhuo-ming,Yue Z,et al.SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction[J].Molecular and Cellular Endocrinology,2018,460(C):1-13.

备注/Memo

备注/Memo:
(2018-09-29收稿)
更新日期/Last Update: 2019-04-20