[1]彭娟 崔莉红 秦有智.神经生长因子辅助治疗高血压性脑出血的效果及对水通道蛋白、氧化应激因子水平的影响[J].卒中与神经疾病杂志,2019,26(02):182-184.[doi:10.3969/j.issn.1007-0478.2019.02.013]
　Peng Juan*,Cui Lihong,Qin Youzhi.*.The effects of nerve growth factor on cell factors,recovery of nerve function defect and quality of daily life of the patients with hypertensive intracerebral hemorrhage(HICH)[J].Stroke and Nervous Diseases,2019,26(02):182-184.[doi:10.3969/j.issn.1007-0478.2019.02.013]
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神经生长因子辅助治疗高血压性脑出血的效果及对水通道蛋白、氧化应激因子水平的影响()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第26卷
期数:
2019年02期
页码:
182-184
栏目:
论 著
出版日期:
2019-04-20

文章信息/Info

Title:
The effects of nerve growth factor on cell factors,recovery of nerve function defect and quality of daily life of the patients with hypertensive intracerebral hemorrhage(HICH)
文章编号:
1007-0478(2019)02-0186-04
作者:
彭娟 崔莉红 秦有智
神经生长因子 高血压性脑出血 神经功能缺损 生活质量 水通道蛋白
Author(s):
Peng Juan*; Cui Lihong; Qin Youzhi.*
Department of Neurology,Nursing Home of Shangluo,Shaanxi 726000
Keywords:
Nerve growth factor Hypertensive intracerebral hemorrhage Nerve function defect Quality of life Aquaporin
分类号:
R743.34
DOI:
10.3969/j.issn.1007-0478.2019.02.013
文献标志码:
A
摘要:
目的 分析神经生长因子辅助治疗高血压性脑出血(HICH)的效果及对水通道蛋白、氧化应激因子水平的影响。方法 选取本院2016年2月-2017年12月收治的HICH患者74例,根据治疗方法不同分为对照组和观察组; 对照组患者采用常规治疗,观察组患者采用常规治疗+神经生长因子治疗,分析2组患者治疗后的临床效果。结果 治疗前2组患者血肿量、水肿体积、NIHSS评分和Barthel指数评分比较无明显差异(P>0.05); 治疗后观察组患者血肿量、水肿体积、NIHSS评分低于对照组,Barthel指数评分高于对照组(P<0.05)。治疗前2组患者MMP-9、SOD、GSH-Px、AQP-1、AQP-4水平比较无明显差异(P>0.05); 治疗后观察组患者SOD、GSH-Px水平高于对照组,MMP-9、AQP-1、AQP-4水平低于对照组(P<0.05)。结论 神经生长因子辅助治疗HICH可缩小水肿体积,降低MMP-9、AQP蛋白水平,提高SOD、GSH-Px水平,促进神经功能缺损恢复,提高日常生活质量。
Abstract:
ObjectiveTo analyze the effects of nerve growth factor(NGF)on cell factors,the recovery of nerve function defect and the quality of daily life of the patients with hypertensive intracerebral hemorrhage(HICH).Methods From February 2016 to December 2017,74 patients with HICH were selected and divided into control group and observation group according to different treatment methods.The patients in the control group were treated with routine therapy,and the patients in the observation group were treated with nerve growth factor.Results Before treatment,there were no significant differences in hematoma volume,edema volume and NIHSS score and Barthel index score between the two groups(P>0.05).After treatment,the scores of hematoma volume,edema volume and NIHSS in the observation group were lower than those in the control group(P<0.05),and the scores of Barthel index in the control group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences between the two groups in the levels of MMP-9/SODX GSH-PxAAQP-1and AQP-4(P>0.05).After treatment,the levels of MMP-9,AQP-1,AQP-4 of the observation group were significantly lower than those of the control group(P<0.05).Conclusion Nerve growth factor adjuvant treatment of HICH could reduce the volume of edema,the levels of MMP-9,AQP protein,promote the recovery of nerve function defect and improve the quality of daily life.

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备注/Memo

备注/Memo:
(2018-06-12收稿)
更新日期/Last Update: 2019-04-20