[1]张锐 王洪海 王磊 姜明一 王永春 马梦冰 钟池.伴有胰岛素抵抗的复发动脉粥样硬化型脑梗死患者阿司匹林抵抗与COX-1基因多态性的相关性研究[J].卒中与神经疾病杂志,2019,26(03):266-270285.[doi:10.3969/j.issn.1007-0478.2019.03.003]
　Zhang Rui,Wang Honghai,Wang Lei,et al.The association between aspirin resistance and COX-1 gene polymorphism in patients with recurrent atherosclerotic infarction with insulin resistance[J].Stroke and Nervous Diseases,2019,26(03):266-270285.[doi:10.3969/j.issn.1007-0478.2019.03.003]
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伴有胰岛素抵抗的复发动脉粥样硬化型脑梗死患者阿司匹林抵抗与COX-1基因多态性的相关性研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第26卷
期数:
2019年03期
页码:
266-270285
栏目:
论 著
出版日期:
2019-06-25

文章信息/Info

Title:
The association between aspirin resistance and COX-1 gene polymorphism in patients with recurrent atherosclerotic infarction with insulin resistance
文章编号:
1007-0478(2019)03-0266-06
作者:
张锐 王洪海 王磊 姜明一 王永春 马梦冰 钟池
261000 山东省潍坊医学院附属潍坊市人民医院神经内科[张锐 王洪海 王磊 马梦冰 钟池(通信作者)]; 山东省潍坊市人民医院脑科分院检验科(姜明一 王永春)
Author(s):
Zhang Rui;  Wang Honghai;  Wang Lei;  et al
Department of Neurology, Weifang People's Hospital Affiliated to Weifang Medical University, Weifang Shandong 261000
关键词:
胰岛素抵抗 复发脑梗死 阿司匹林抵抗 基因多态性
Keywords:
Insulin resistance Recurrent cerebral infarction Aspirin resistance Gene polymorphism
分类号:
R743.32
DOI:
10.3969/j.issn.1007-0478.2019.03.003
文献标志码:
A
摘要:
目的 探讨伴有胰岛素抵抗的复发动脉粥样硬化型脑梗死患者阿司匹林抵抗与COX-1基因多态性的关系。方法 收集住院的复发动脉粥样硬化型脑梗死(atherosclerotic cerebral infarction,ACI)患者300例,通过ELISA方法测定尿11-d-TXB2水平,并根据其水平分为阿司匹林抵抗组和非阿司匹林抵抗组,同时测定空腹血糖(Fast Plasma Glucose,FPG)、空腹胰岛素(Fast Insulin, FINS)水平,观察2组患者胰岛素抵抗(insulin resistance,IR)的发生率; 同时采用多聚酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)技术测定COX-1基因A-842G位点多态性。结果 阿司匹林抵抗组胰岛素抵抗率更高; 阿司匹林抵抗组中G等位基因频率(18.7%)明显高于非阿司匹林抵抗组(2.6%)(P<0.05); 携带等位基因G的个体患有阿司匹林抵抗是非等位基因G携带者的2.108倍(OR=2.108; 95%CI=2.049～4.237)。结论 伴有胰岛素抵抗的复发动脉粥样硬化型脑梗死患者阿司匹林抵抗可能与COX-1基因A-842G位点存在相关性。
Abstract:
ObjectiveTo investigate the association between aspirin resistance and COX-1 gene polymorphism in patients with recurrent atherosclerotic infarction with insulin resistance.Methods a total of 300 patients with recurrent atherosclerotic cerebral infarction were collected. Urinary 11-d-TXB2 was determined by ELISA. According to the results, the patients were divided into aspirin resistance group and non resistance group. Fasting blood glucose(Fast Plasma Glucose, FPG)and fasting insulin(Fast Insulin, FINS)were measured and the incidence of insulin resistance in two groups was observed. Polymerase chain reaction-restriction endonuclease fragment length polymorphism(PCR-RFLP)was used to detect A-842G polymorphism of COX-1 gene. The general data are compared.Results the frequency of G allele in aspirin resistance group(18.7%)was significantly higher than that in non-aspirin resistance group(2.6%)(P<0.05). Individuals with allelic G had 2.108 times as much resistance to aspirin as non-allelic G carriers(OR=2.108; 95%CI=2.049-4.237).Conclusion aspirin resistance in patients with recurrent atherosclerotic infarction with insulin resistance may be associated with A-842G locus of COX-1 gene.

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备注/Memo

备注/Memo:
基金项目:潍坊市科技局(医学类)(项目编号为2017YX020)
更新日期/Last Update: 2019-06-25