[1]祁晓媛 范桂梅 贾鸿宁 吴慧君 姚玉芳 张丽华.拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响[J].卒中与神经疾病杂志,2020,27(02):205-208.[doi:10.3969/j.issn.1007-0478.2020.02.014]
　Qi Xiaoyuan,Fan Guimei,Jia Hongning,et al.Clinical effect of lamotrigine in the adjuvant treatment of vestibular migraine and its effect on serum neurotransmitter levels[J].Stroke and Nervous Diseases,2020,27(02):205-208.[doi:10.3969/j.issn.1007-0478.2020.02.014]
点击复制

拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第27卷
期数:
2020年02期
页码:
205-208
栏目:
论 著
出版日期:
2020-03-15

文章信息/Info

Title:
Clinical effect of lamotrigine in the adjuvant treatment of vestibular migraine and its effect on serum neurotransmitter levels
文章编号:
1007-0478(2020)02-0205-04
作者:
祁晓媛 范桂梅 贾鸿宁 吴慧君 姚玉芳 张丽华
061000 河北沧州市中心医院神经内四科[祁晓媛 范桂梅 贾鸿宁 吴慧君 姚玉芳 张丽华(通信作者)]
Author(s):
Qi Xiaoyuan;  Fan Guimei;  Jia Hongning;  et al.
Internal Medicine-Neurology, Cangzhou Central Hospital, Cangzhou Hebei 061000
关键词:
拉莫三嗪 氟桂利嗪 前庭性偏头痛 眩晕 神经递质
Keywords:
Lamotrigine Flunarizine Vestibular migraine Vertigo Neurotransmitters
分类号:
R747.2
DOI:
10.3969/j.issn.1007-0478.2020.02.014
文献标志码:
A
摘要:
目的 探讨拉莫三嗪辅助治疗前庭性偏头痛的临床效果及对血清神经递质水平的影响。方法 选择本院2018年4月-2019年7月接诊的前庭性偏头痛患者85例,通过随机数表法分为观察组45例和对照组40例,对照组给予盐酸氟桂利嗪胶囊治疗,观察组给予盐酸氟桂利嗪胶囊联合拉莫三嗪治疗,均连续治疗2个月,并比较2组临床疗效、眩晕情况、血清神经递质水平的变化及不良反应。结果 治疗2个月后观察组总有效率明显高于对照组(91.11% vs 72.50%)(P<0.05); 观察组眩晕发作次数、每次眩晕严重程度均明显低于对照组,眩晕持续时间明显短于对照组[(2.05±0.47)vs(2.94±0.61)次/月,(2.43±0.63)vs(3.59±0.88)分,(8.76±1.74)vs(10.09±2.11)h](P<0.05); 观察组血清降钙素基因相关肽(CGRP)、P物质(SP)、内皮素-1(ET-1)水平明显低于对照组[(56.75±8.01)vs(66.42±9.65)ng/L,(162.30±15.42)vs(184.21±17.27)ng/L,(72.30±11.38)vs(88.27±13.47)pg/mL](P<0.05); 2组不良反应总发生率无明显差异[13.33% vs 12.50%](P>0.05)。结论 在氟桂利嗪基础上联合拉莫三嗪辅助治疗前庭性偏头痛的疗效显著,可有效改善血清神经递质表达水平,缓解临床症状,安全性好
Abstract:
ObjectiveTo study the clinical effect of lamotrigine in the adjuvant treatment of vestibular migraine and its effect on serum neurotransmitter levels.Methods 85 patients of vestibular migraine who received therapy from April 2018 to December 2019 in our hospital were selected, according to the random number table, those patients were divided into 45 cases in the observation group and 40 cases in the control group, the control group was treated with Flunarizine Hydrochloride Capsules, while the observation group was combined with lamotrigine, they were treated continuously for two months. The clinical efficacy, vertigo, changes of serum neurotransmitter levels and adverse reactions were compared between the two groups.Results After treatment, the total effective rate in the observation group was higher than that in the control group [91.11% vs 72.50%](P<0.05). The number of vertigo attacks and the severity of vertigo in the observation group were lower than those in the control group, and the duration of vertigo was significantly shorter than that in the control group [(2.05±0.47)vs(2.94±0.61)time/months,(2.43±0.63)vs(3.59±0.88)scores,(8.76±1.74)vs(10.09±2.11)h](P<0.05). The serum levels of calcitonin gene-related peptide(CGRP), substance P(SP), endothelin-1(ET-1)in the observation group were lower than those in the control group [(56.75±8.01)vs(66.42±9.65)ng/L,(162.30±15.42)vs(184.21±17.27)ng/L,(72.30±11.38)vs(88.27±13.47)pg/mL](P<0.05). There was no significant difference in the total incidence of adverse reactions in the the two groups [13.33% vs 12.50%](P>0.05).Conclusion On the basis of flunarizine, combined with lamotrigine adjuvant treatment was weel for vestibular migraine, which could effectively improve the expression levels of serum neurotransmitters, alleviate clinical symptoms, and had good safety, it was worth popularizing

参考文献/References:

[1] Formeister EJ,Rizk HG,Kohn MA,et al.The epidemiology of vestibular migraine: a population-based survey study[J].Otology & Neurotology,2018,39(8):1037-1044.
[2] 申博,杨波,隋汝波,等.前庭性偏头痛[J].神经损伤与功能重建,2017,12(4):343-345.
[3] 张勇,侯静,冯军,等.丙戊酸钠治疗偏头痛持续状态的有效性和安全性研究[J].中国实用神经疾病杂志,2015,18(11):19-20.
[4] Beh SC.Vestibular migraine:how to sort it out and what to do about it[J].J Neuroophthalmol,2019,39(2):208-219.
[5] 中国医师协会神经内科医师分会疼痛和感觉障碍学组,中国医药教育协会眩晕专业委员会,中国研究型医院学会头痛与感觉障碍专业委员会.前庭性偏头痛诊治专家共识(2018)[J].中国疼痛医学杂志,2018,24(07):481-488.
[6] 严广斌.视觉模拟评分法[J].中华关节外科杂志(电子版),2014,8(2):273.
[7] 周丽丽,王文昭,杨月嫦,等.前庭性偏头痛的研究现状[J].临床耳鼻咽喉头颈外科杂志,2016,30(24):1983-1986.
[8] Udagatti VD,Dinesh KR.Migraine related vertigo[J].Indian J Otolaryngol Head Neck Surg,2017,69(4):563-567.
[9] Carvalho GF,Vianna-Bell FH,Florencio LL,et al.Presence of vestibular symptoms and related disability in migraine with and without aura and chronic migraine[J].Cephalalgia,2019,39(1):29-37.
[10] 刘馨怡,张军莉,潘永惠.前庭性偏头痛的临床表现和认知功能改变与血清学指标的变化[J].中国临床神经科学,2017,25(6):705-709.
[11] 袁庆,刘得龙,余力生,等.氟桂利嗪预防性治疗前庭性偏头痛眩晕发作的前瞻性随机对照研究[J].临床耳鼻咽喉头颈外科杂志,2016,30(10):805-810.
[12] Feil K,Boettcher N,Kremmyda O,et al.Pharmacotherapy of vestibular disorders, nystagmus and cerebellar disorders[J].Fortschr Neurol Psychiatr,2015,83(9):490-498.
[13] 林尧,董红娟,肖哲曼.癫痫与偏头痛共病研究进展[J].神经损伤与功能重建,2018,13(04):190-192.
[14] Lampl C,Katsarava Z,Diener HC,et al.Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura[J].Journal of Neurology Neurosurgery & Psychiatry,2005,76(12):1730.
[15] Pascual J,Caminero AB,Mateos V,et al.Preventing disturbing migraine aura with lamotrigine: An open study[J].Headache,2004,44(10):1024-1028.
[16] 杜欢,曹学兵.拉莫三嗪对偏头痛的预防性治疗研究进展[J].中国神经免疫学和神经病学杂志,2012,19(3):238-241.

备注/Memo

备注/Memo:
基金项目:沧州市科学技术研究与发展指导计划项目(项目编号为172302101)(2019-07-25收稿)
更新日期/Last Update: 2020-03-15