[1]申兴革 魏巍.血清MCP-1、HSP70、AOPP水平与OSAHS患者认知功能障碍的相关性分析[J].卒中与神经疾病杂志,2020,27(02):209-211.[doi:10.3969/j.issn.1007-0478.2020.02.015]
　Shen Xingge,Wei Wei..The correlation between cognitive impairment in patients with obstructive sleep apnea syndrome(OSAHS)and serum MCP-1, HSP70, AOPP levels[J].Stroke and Nervous Diseases,2020,27(02):209-211.[doi:10.3969/j.issn.1007-0478.2020.02.015]
点击复制

血清MCP-1、HSP70、AOPP水平与OSAHS患者认知功能障碍的相关性分析()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第27卷
期数:
2020年02期
页码:
209-211
栏目:
论 著
出版日期:
2020-03-15

文章信息/Info

Title:
The correlation between cognitive impairment in patients with obstructive sleep apnea syndrome(OSAHS)and serum MCP-1, HSP70, AOPP levels
文章编号:
1007-0478(2019)05-0509-05
作者:
申兴革 魏巍
071000 河北保定市中西医结合肿瘤治疗中心/保定市恒兴中西医结合医院内科
Author(s):
Shen Xingge; Wei Wei.
Internal Medicine,Baoding Integrated Traditional Chinese and Western Medicine Tumor Treatment Center/Baoding Hengxing Integrated Traditional Chinese and Western Medicine Hospital,Baoding Hebei 071000
关键词:
阻塞性睡眠呼吸暂停低通气综合征 认知功能障碍 单核细胞趋化蛋白-1 热休克蛋白70 晚期氧化蛋白产物
Keywords:
Obstructive sleep apnea syndrome Cognitive dysfunction Monocyte chemotactic protein-1 Heat shock protein 70 Advanced oxidative protein products
分类号:
R742.8+9
DOI:
10.3969/j.issn.1007-0478.2020.02.015
文献标志码:
A
摘要:
目的 探讨血清单核细胞趋化蛋白-1(MCP-1)、热休克蛋白70(HSP70)、晚期氧化蛋白产物(AOPP)水平与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能障碍的相关性。方法 选择2017年3月-2018年3月本院接诊的66例阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者作为观察组,并选择同期于本院接受体检的健康体检者62例作为对照组,比较2组受试者及不同严重程度OSAHS患者血清MCP-1,HSP70,AOPP水平、呼吸暂停低通气指数(AHI)、蒙特利尔认知评估量表(MoCA)和ESS评分,分析血清MCP-1,HSP70,AOPP水平与AHI,MoCA和ESS评分的相关性。结果 观察组血清MCP-1、HSP70、AOPP水平、AHI和ESS评分均明显高于对照组,MoCA评分明显低于对照组(P<0.05); 不同严重程度OSAHS患者血清MCP-1、HSP70、AOPP水平、AHI、MoCA和ESS评分比较均有明显差异(P<0.05); 经Spearman 相关分析显示,血清MCP-1,HSP70,AOPP水平和AHI,ESS评分均呈正相关(P<0.05),与MoCA评分呈负相关(P<0.05)。结论 OSAHS患者血清MCP-1,HSP70,AOPP水平明显升高,其机制可能通过炎症刺激、氧化应激等途径来加重患者认知功能障碍程度。
Abstract:
ObjectiveTo investigate the correlation between cognitive impairment in patients with obstructive sleep apnea syndrome(OSAHS)and serum monocyte chemoattractant protein-1(MCP-1), heat shock protein 70(HSP70), advanced oxidative protein product(AOPP)levels.Methods 66 patients with obstructive sleep apnea syndrome(OSAHS)admitted to our hospital from March 2017 to March 2018 were selected as observation group, and 62 healthy people who underwent physical examination in our hospital during the same period were selected as control group. Serum MCP-1, HSP70, AOPP levels, apnea hypopnea index(AHI)and Montreal cognitive assessment were compared between two groups and OSAHS patients with different severity. the correlation between serum MCP-1, HSP70, AOPP levels and AHI, MoCA and ESS scores was analyzed.Results The serum MCP-1, HSP70, AOPP levels, AHI and ESS scores of the observation group were significantly higher than those of the control group, and the MoCA scores were significantly lower than those of the control group(P< 0.05). The serum MCP-1, HSP70, AOPP levels, AHI, MoCA and ESS scores of OSAHS patients with different severity were significantly different(P< 0.05). The Spearman correlation analysis showed that serum MCP-1, HSP70, AOPP levels and AHI, ESS scores were positively correlated, while they were negatively correlated with MoCA scores(P< 0.05).Conclusion The expression levels of MCP-1, HSP70 and AOPP in serum of OSAHS patients were significantly increased, it could aggravate the degree of cognitive impairment by inflammation and oxidative stress.

参考文献/References:

[1]唐旋,张梅,周宁,等.阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍研究现状[J].临床耳鼻咽喉头颈外科杂志,2017,31(10):813-816.
[2]戈艳蕾,刘聪辉,付爱双,等.COPD-OSAHS重叠综合征患者认知功能障碍与血清MCP-1及SAA水平变化的临床意义[J].临床耳鼻咽喉头颈外科杂志,2018,32(7):485-488.
[3]AraslanovaR,ParadisJ,RotenbergBW.Publicationtrendsinobstructivesleepapnea:Evidenceofneedformoreevidence[J].Worldjournalofotorhinolaryngology-headandnecksurgery,2017,3(2):72-78.
[4]何权瀛,王莞尔.阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)[J].中国呼吸与危重监护杂志,2015,14(4):398-405.
[5]魏晓泉,谢宇平,惠培林,等.阻塞性睡眠呼吸暂停低通气综合征患者不同睡眠体位下呼吸暂停低通气指数和血氧饱和度下降指数的变化分析[J].中国耳鼻咽喉头颈外科,2015,22(10):493-496.
[6]杨立新,唐旋,周宁,等.北京版蒙特利尔认知评估量表在成人OSAHS认知功能评估中的应用及可靠性验证[J].临床耳鼻咽喉头颈外科杂志,2018,32(1):58-64.
[7]陈曦,章榕,王洪洪,等.Epworth嗜睡量表和微觉醒指数在重度OSAHS患者病情评估中的价值[J].临床耳鼻咽喉头颈外科杂志,2017,31(3):167-169.
[8]刘建伟,陈葵,刘松.阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的研究进展[J].国际呼吸杂志,2014,34(17):1343-1348.
[9]窦占军,王蓓,郭婧,等.氧化应激对阻塞性睡眠呼吸暂停低通气综合征肾损害的作用与抗氧化治疗现状[J].中国药物与临床,2017,17(8):1160-1162.
[10]王燕,窦占军,曹莉,等.氧化应激在OSAHS所致肾损害中的作用机制及抗氧化干预的研究进展[J].国际呼吸杂志,2016,36(6):461-464.
[11]GeYL,LiuCH,FuAS,etal.CorrelationstudybetweenthelevelsofserumMCP-1,SAAandcognitivefunctioninpatientswithCOPD-OSAHS[J].LinChungErBiYanHouTouJingWaiKeZaZhi,2018,32(7):485-488.
[12](·overI)nE,?demirC,KamanD,etal.Heatshockproteins,L-Arginine,andasymmetricdimethylargininelevelsinpatientswithobstructivesleepapneasyndrome[J].ArchBronconeumol,2015,51(11):544-550.
[13]QuB,JiaY,LiuY,etal.Thedetectionandroleofheatshockprotein70invariousnondiseaseconditionsanddiseaseconditions:aliteraturereview[J].CellStressChaperones,2015,20(6):885-892.
[14]PassaliD,CoralloG,YaremchukS,etal.Oxidativestressinpatientswithobstructivesleepapnoeasyndrome[J].ActaOtorhinolaryngolItal,2015,35(6):420-425.
[15]邓永君,鲁建光,胡欣,等.阻塞性睡眠呼吸暂停低通气综合征患者血清代谢指标分析及其临床意义[J].临床耳鼻咽喉头颈外科杂志,2014,28(12):848-851.

备注/Memo

备注/Memo:
(2019-07-01收稿)
更新日期/Last Update: 2020-03-15