参考文献/References:
[1] Dickson BJ,Gilestro GF.Regulation of commissural axon pathfinding by slit and its robo receptors[J].Annu Rev Cell Dev Biol,2006,22(1):651-675.
[2] Kidd T.Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors[J].Cell,1998,92(2):205.
[3] Pircher A,Schaefer G,Eigentler A,et al.Robo 4-the double-edged sword in prostate cancer: impact on cancer cell aggressiveness and tumor vasculature[J].Int J Med Sci,2018,41(4):323.
[4] Smith-Berdan S,Nguyen A,Hong MA.ROBO4-Mediated vascular integrity regulates the directionality of hematopoietic stem cell trafficking[J].Stem Cell Reports,2015,4(2):255-268.
[5] Phuong TT,Walker AE,Henson GD,et al.Deletion of Robo4 prevents high-fat diet-induced adipose artery and systemic metabolic dysfunction[J].Microcirculation,2019,26(5, SI):e12540.
[6] Gould RA,Aziz H,Woods CE,et al.ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm[J].Nat Genet,2019,51(1):42.
[7] Romano E,Manetti M,Rosa I,et al.Slit2/Robo4 axis May contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis[J].Ann Rheum Dis,2018,77(11):1665-1674.
[8] Weng J,Zhou XM,Xie H,et al.Slit2/Robo4 signaling pathway modulates endothelial hyper-permeability in a two-event in vitro model of transfusion-related acute lung injury[J].Blood Cells Molecules and Diseases,2019,76:7-12.
[9] Gong QY,Li FQ,Xie J,et al.Upregulated VEGF and Robo4 correlate with the reduction of miR-15a in the development of diabetic retinopathy[J].Endocrine,2019,65(1):35-45.
[10] Jiang SQ,Du Y,Liu BN,et al.Inhibitory effect of slit2-N on VEGF165-induced proliferation of vascular endothelia via slit2-N-Robo4-Akt pathway in choroidal neovascularization[J].Cell Cycle,2019,18(11):1241-1253.
[11] Huminiecki L,Gorn M,Suchting S,et al.Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis[J].Genomics,2002,79(4):547-552.
[12] Dai C,Gong QY,Cheng Y,et al.Regulatory mechanisms of Robo4 and their effects on angiogenesis[J].Biosci Rep,2019,39(7):1-34.
[13] Yadav S S,Narayan G.Role of ROBO4 signalling in developmental and pathological angiogenesis[J].BioMed Research International,2014,2014:1-9.
[14] Morioka T,Sakabe M,Loka T,et al.An important role of endothelial hairy-related transcription factors in mouse vascular development[J].Genesis,2014,52(11):897-906.
[15] Brose K,Bland KS,Wang KH,et al.Slit proteins bind Robo receptors and have an evolutionarily conservedrole in repulsive axon guidance[J].Cell,1999,96(6):795-806.
[16] Wu JY,Feng LL,Park HT,et al.The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors[J].Nature,2001,410(6831):948-952.
[17] Chen JH,Wen L,Dupuis S,et al.The N-terminal Leucine-Rich Regions in Slit Are Sufficient ToRepel Olfactory Bulb Axons and Subventricular Zone Neurons[J].The Journal of Neuroscience,2001,21(5):1548-1556.
[18] Park KW,Morrison CM,Sorensen LK,et al.Robo4 is a vascular-specific receptor that inhibits endothelial migration[J].Dev Biol,2003,261(1):251-267.
[19] Suchting S,Heal P,Tahtis K,et al.Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration[J].FASEB Journal,2005,19(1):121-123.
[20] Chen CY,Tsai CH,Chen CY,et al.Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling[J].Cell Adh Migr,2016,10(1/2, SI):66-76.
[21] Jones CA,London NR,Chen HY,et al.Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability[J].Nat Med,2008,14(4):448-453.
[22] Jones CA,Nishiya N,London NR,et al.Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity[J].Nat Cell Biol,2009,11(11):U146-1325.
[23] Qiu H,Xiao W,Yue J,et al.Heparan sulfate modulates Slit3-induced endothelial cell migration[J].Methods Mol Biol,2015,1229:549-555.
[24] Zhang B,Xiao WY,Qiu H,et al.Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia[J].Journal of Clinical Investigation,2014,124(1):209-221.
[25] Paul JD,Coulombe KL,Toth PT,et al.SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo[J].J Mol Cell Cardiol,2013,64:124-131.
[26] Koch AW,Mathivet T,Larrivee B,et al.Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B[J].Dev Cell,2011,20(1):33-46.
[27] Zhang F,Prahst C,Mathivet TA,et al.The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization[J].Nat Commun,2016,7:13517.
[28] Li W,Chen Z,Yuan J,et al.Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability[J].Journal of Cerebral Blood Flow & Metabolism,2018:0271678X1877791.
[29] Sherchan P,Huang L,Akyol O,et al.Recombinant slit2 reduces surgical brain injury induced blood brain barrier disruption via Robo4 dependent Rac1 activation in a rodent model[J].Sci Rep,2017,7(1):746-756.
[30] Abdelsaid M,Coucha M,Hafez S,et al.Enhanced VEGF signalling mediates cerebral neovascularisation via downregulation of guidance protein ROBO4 in a rat model of diabetes[J].Diabetologia,2017,60(4):740-750.