[1]柯伟 李文澜 邓小容.血流储备分数(FFR)在重度颈内动脉狭窄中的实验研究[J].卒中与神经疾病杂志,2020,27(04):513-516.[doi:10.3969/j.issn.1007-0478.2020.04.022]
　Ke Wei*,Li Wenlan,Deng Xiaorong..The application of fractional flow reserve(FFR)in severe internal carotid artery stenosis[J].Stroke and Nervous Diseases,2020,27(04):513-516.[doi:10.3969/j.issn.1007-0478.2020.04.022]
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血流储备分数(FFR)在重度颈内动脉狭窄中的实验研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第27卷
期数:
2020年04期
页码:
513-516
栏目:
血管介入术
出版日期:
2020-09-10

文章信息/Info

Title:
The application of fractional flow reserve(FFR)in severe internal carotid artery stenosis
文章编号:
1007-0478(2020)04-0513-04
作者:
柯伟 李文澜 邓小容
430060 武汉大学人民医院神经内科(柯伟),麻醉科[李文澜(通信作者)]; 湖北省第三人民医院神经内科(邓小容)
Author(s):
Ke Wei*;  Li Wenlan;  Deng Xiaorong.
*Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060
关键词:
颈内动脉 狭窄 血流储备分数
Keywords:
Internal carotid artery Stenosis Fractional flow reserve(FFR
分类号:
R543.5
DOI:
10.3969/j.issn.1007-0478.2020.04.022
文献标志码:
A
摘要:
目的 探讨血流储备分数(Fractional flow reserve,FFR)在颈内动脉狭窄血管内介入治疗评估中的意义。方法 将50只兔子随机分为正常组(n=10)和模型组(重度颈内动脉狭窄组)(n=40),并进行编号,采用结扎法建立兔颈内动脉重度狭窄的模型,模型组采用DSA的方法评估血管狭窄率及模型的可靠性; 测得重度狭窄颈内动脉的狭窄近端压力(Pa)、狭窄远端压力(Pd)的数值,计算出Ic-FFR(Pd/Pa)值,并得出模型组Pa、Pd值与时间(s)的变化曲线; 采用回归分析颈内动脉狭窄率与Ic-FFR的相关性。结果 40例中35例(87.5%)符合颈内动脉重度狭窄,5例(12.5%)没有达到重度狭窄的标准。模型组Pd、Pa的值在20 s达到最大值,持续维持一段时间,最大值后40 s内Pd、Pa的值未见明显变化。正常组Ic-FFR值为1。模型组35例颈内动脉重度狭窄中测得Pa值为(103.029±5.404)mmHg,中位数为104 mmHg; Pd值为(87.882±5.031)mmHg,中位数为88.110 mmHg; Ic-FFR值为0.853±0.026,中位数为0.86; 颈内动脉狭窄率与Ic-FFR呈负相关(r=-0.65,P<0.05)。结论 颈内动脉血流储备分数(Internal carotid artery fractional flow reserve,Ic-FFR)为颈动脉狭窄血管内介入治疗评估提供一定的理论基础
Abstract:
ObjectiveTo investigate the feasibility of fractional flow reserve(FFR)in the treatment of internal carotid artery stenosis.Methods Fifty rabbits were randomly divided into normal group(n=10)and model group(n=40)and numbered. The model group was severe internal carotid artery stenosis group(n=40). A rabbit model of severe internal carotid artery stenosis was established by ligation method. The proximal pressure(Pa)and the dista pressure(Pd)of internal carotid artery stenosis were measured, and the FFR(Pd/Pa)was calculated. The change curves of Pa, Pd and time(S)in the model group were obtained. The correlation between the rate of internal carotid stenosis and Ic-FFR was analyzed by regression.Results In the model group DSA was used to evaluate the stenosis rate and the reliability of the model. Among the 40 cases, 35 cases(87.5%)met the criteria of severe internal carotid artery stenosis, and 5 cases(12.5%)did not meet the criteria of severe stenosis. The Pd and Pa in the model group reached the maximum in 20 s, which was maintained for a period of time, and there was no significant change within 40 s after the maximum. The internal carotid artery fractional flow reserve(Ic-FFR)of normal group was 1.0. The Pa of model group was(103.029±5.404)mmHg and the median was 104.000 mmHg mmHg. The Pd of model group was value was(87.882±5.031)mmHg, and the median was 88.110 mmHg. The Ic-FFR(Pd/Pa)was 0.853±0.026, the median was 0.86. The rate of internal carotid artery stenosis was negatively correlated with Ic-FFR(r=-0.65,P<0.05).Conclusion The Ic-FFR provided a basic theory in the treatment of internal carotid artery stenosis

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备注/Memo

备注/Memo:
(2019-06-23收稿)基金项目:血流储备分数(FFR)中重度颈内动脉狭窄中的实验研究(WJ2015MB127)
更新日期/Last Update: 2020-09-10