[1]宋文英 赵静 唐浩 苟宁 周娇.急性脑梗死合并2型糖尿病患者血清Caveolin-1的水平变化及其与早期神经功能恶化的关系[J].卒中与神经疾病杂志,2020,27(05):580-584.[doi:10.3969/j.issn.1007-0478.2020.05.005]
　Song Wenying,Zhao Jing,Tang Hao,et al.The change of serum caveolin-1 level in acute cerebral infarction patients complicated with type 2 diabetes mellitus and its relationship with early neurological deterioration[J].Stroke and Nervous Diseases,2020,27(05):580-584.[doi:10.3969/j.issn.1007-0478.2020.05.005]
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急性脑梗死合并2型糖尿病患者血清Caveolin-1的水平变化及其与早期神经功能恶化的关系()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第27卷
期数:
2020年05期
页码:
580-584
栏目:
论 著
出版日期:
2020-10-20

文章信息/Info

Title:
The change of serum caveolin-1 level in acute cerebral infarction patients complicated with type 2 diabetes mellitus and its relationship with early neurological deterioration
文章编号:
1007-0478(2020)05-0580-05
作者:
宋文英 赵静 唐浩 苟宁 周娇
Author(s):
Song Wenying;  Zhao Jing;  Tang Hao;  et al.
Department of Anesthesiology, Shanxi Provincial Hospital, Xi'an 710068
关键词:
急性脑梗死 2型糖尿病 陷窝蛋白-1 早期神经功能恶化 危险因素 预测
Keywords:
Acute cerebral infarction Type 2 diabetes mellitus Caveolin-1 Early neurological deterioration Risk factors Prediction
分类号:
R743.3 R587.1
DOI:
10.3969/j.issn.1007-0478.2020.05.005
文献标志码:
A
摘要:
目的 探讨急性脑梗死合并2型糖尿病患者血清陷窝蛋白-1(Caveolin-1)的水平变化及其与早期神经功能恶化(END)的关系。方法 选择2018年1月-2019年12月本院收治的急性脑梗死合并2型糖尿病患者、急性脑梗死患者、2型糖尿病患者、健康志愿者,检测血清Caveolin-1的水平,评价急性脑梗死合并2型糖尿病患者的END,采用Logistic回归分析END的影响因素,采用ROC曲线分析Caveolin-1水平对END的预测价值。结果 急性脑梗死合并2型糖尿病组患者的血清Caveolin-1水平高于急性脑梗死组、2型糖尿病组、对照组(P<0.05); 急性脑梗死合并2型糖尿病组END患者的Caveolin-1水平、女性比例、入院时NIHSS评分、起病至入院时间、糖化血红蛋白、随机血糖、hs-CRP水平均高于非END患者(P<0.05); logistics回归分析显示,Caveolin-1水平增高、女性、糖化血红蛋白水平增高及入院时NIHSS评分增加是急性脑梗死合并2型糖尿病组患者END的危险因素(P<0.05); ROC曲线分析显示,血清Caveolin-1对急性脑梗死合并2型糖尿病患者的END具有预测价值,最佳截点为34.95 ng/mL。结论 血清Caveolin-1水平升高是急性脑梗死合并2型糖尿病患者END的危险因素,且对END具有预测价值。
Abstract:
ObjectiveTo study the change of serum caveolin-1 level in acute cerebral infarction patients complicated with type 2 diabetes mellitus and its relationship with early neurological deterioration(END).Methods From January 2018 to December 2019, patients with acute cerebral infarction and type 2 diabetes, patients with acute cerebral infarction, patients with type 2 diabetes and healthy volunteers were selected. Then serum caveolin-1 level was detected, the END of acute cerebral infarction patients complicated with type 2 diabetes mellitus was evaluated, the influencing factors of END was analyzed by logistic regression, and the predictive value of caveolin-1 for END was analyzed by ROC curve.Results The serum caveolin-1 level of acute cerebral infarction complicated with type 2 diabetes mellitus group was higher than those of the acute cerebral infarction group, type 2 diabetes mellitus group and control group(P<0.05). The serum caveolin-1 level, the proportion of female, the NIHSS score on admission, the time from onset to admission, glycosylated hemoglobin, random blood glucose and hs-CRP levels of END patients in acute cerebral infarction complicated with type 2 diabetes mellitus group were all higher than that of non END patients in acute cerebral infarction complicated with type 2 diabetes mellitus group(P<0.05). Logistic regression analysis showed that the increasing of caveolin-1 level, female, the increasing of glycosylated hemoglobin level and NIHSS score at admission were the risk factors of END in acute cerebral infarction patients complicated with diabetes mellitus(P<0.05). ROC curve analysis showed that serum caveolin-1 level had predictive value in END in acute cerebral infarction patients complicated with diabetes mellitus, the best cutoff was 34.95 ng/mL(P<0.05).Conclusion The increasing of serum caveolin-1 level was a risk factor of END in acute cerebral infarction patients complicated with diabetes mellitus, and it had a predictive value for END.

参考文献/References:

[1] Tschirret O,Moreno LG,Mansuy A,et al.Impact of brain atrophy on early neurological deterioration and outcome in severe ischemic stroke treated by intravenous thrombolysis[J].Eur Neurol,2018,79(5/6):240-246.
[2] Le SJ,Le DG.Distribution of atherosclerotic stenosis determining early neurologic deterioration in acute ischemic stroke[J].PLoS One,2017,12(9):e0185314.
[3] 王黎明,张雪玲,林晓光,等.血清糖化血红蛋白水平与急性脑梗死早期神经功能恶化的相关性分析[J].中国脑血管病杂志,2016,13(7):348-352.
[4] 黄定良,张会香,张裕生,等.糖尿病与应激性高血糖对急性脑梗死患者预后影响研究[J].中国全科医学,2017,20(S2):30-32.
[5] 钟义良,张融融,黄思源,等.急性脑梗死患者血清陷窝蛋白1水平与早期神经功能恶化的关系[J].上海交通大学学报(医学版),2017,37(12):1678-1681.
[6] 中华医学会神经病学分会.中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[7] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[8] Crewe C,Joffin N,Rutkowski JM,et al.An Endothelial-to-Adipocyte extracellular vesicle axis governed by metabolic state[J].Cell,2018,175(3):695-708.
[9] Kuo A,Lee MY,Yang K,et al.Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin-stimulated,cAMP-mediated lipolysis[J].J Biol Chem,2018,293(3):973-983.
[10] Mierke J,Christoph M,Augstein A,et al.Influence of caveolin-1 and endothelial nitric oxide synthase on adventitial inflammation in aortic transplants[J].Kardiol Pol,2020,78(2):124-130.
[11] Choi KH,Kim HS,Park MS,et al.Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation[J].Oncotarget,2016,7(42):67857-67867.
[12] 瞿伦学,李光勤,费容,等.血清正五聚蛋白3和陷窝蛋白1用于评估急性脑梗死溶栓治疗预后的临床价值[J].中国动脉硬化杂志,2019,27(9):774-778.
[13] 江玮,林硕,鲁红云,等.外周血单个核细胞caveolin-1的表达在新诊断2型糖尿病患者中的变化及其与胰岛素抵抗的关系[J].中山大学学报(医学科学版),2012,33(3):378-382.
[14] Bae GD,Park EY,Kim K,et al.Upregulation of caveolin-1 and its colocalization with cytokine receptors contributes to beta cell apoptosis[J].Sci Rep,2019,9(1):16785.
[15] Haddad D,Al MA,Nizam R,et al.Role of caveolin-1 in diabetes and its complications[J].Oxid Med Cell Longev,2020,27(2020):9761539.
[16] Palacios-Ortega S,Varela-Guruceaga M,Martínez JA,et al.Effects of high glucose on caveolin-1 and insulin signaling in 3T3-L1 adipocytes[J].Adipocyte,2015,5(1):65-80.
[17] 李进军,陈伟良,查曹兵,等.缺血性脑卒中早期神经功能恶化患者超敏C反应蛋白变化及相关因素分析[J].心脑血管病防治,2016,16(3):190-193.
[18] Yc H,Tsai YH,Lee JD,et al.A novel neuroimaging model to predict early neurological deterioration after acute ischemic stroke[J].Curr Neurovasc Res,2018,15(2):129-137.

备注/Memo

备注/Memo:
(2020-03-13收稿)基金项目:陕西省自然科学项目(编号为2018JM7110)作者单位:710068 西安,陕西省人民医院麻醉科
更新日期/Last Update: 2020-10-20