[1]高英英 杨良瑞 应佐华.不同类型的急性脑梗死患者辅助性T细胞及甲基CpG结合蛋白2表达水平变化及其临床意义[J].卒中与神经疾病杂志,2021,28(02):149-152.[doi:10.3969/j.issn.1007-0478.2021.02.003]
　Gao Yingying,Yang Liangrui,Ying Zuohua..The levels of regulatory T cells and MeCP2 protein in patients with different types of acute stroke[J].Stroke and Nervous Diseases,2021,28(02):149-152.[doi:10.3969/j.issn.1007-0478.2021.02.003]
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不同类型的急性脑梗死患者辅助性T细胞及甲基CpG结合蛋白2表达水平变化及其临床意义()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第28卷
期数:
2021年02期
页码:
149-152
栏目:
论 著
出版日期:
2021-04-20

文章信息/Info

Title:
The levels of regulatory T cells and MeCP2 protein in patients with different types of acute stroke
文章编号:
1007-0478(2021)02-0149-04
作者:
高英英 杨良瑞 应佐华
810007 西宁,青海省心脑血管病医院心律失常一科[高英英 杨良瑞(通信作者)应佐华]
Author(s):
Gao Yingying;  Yang Liangrui;  Ying Zuohua.
Department of Arrhythmia, Qinghai Cardiovascular and Cerebrovascular Disease Hospital, Xining Qinghai 810007
关键词:
急性脑梗死 CD4+T细胞 临床意义 甲基CpG结合蛋白2
Keywords:
Acute stroke CD4+ T cells Clinical significance MeCP2
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2021.02.003
文献标志码:
A
摘要:
目的 探讨不同类型的急性脑梗死患者辅助性T细胞(CD4+T cells,CD4+T细胞)及甲基CpG结合蛋白2(Methyl-CpG-binding protein 2,MECP2)表达水平变化及其临床意义。方法 选取本院2017年2月-2019年2月收治的急性脑梗死患者156例作为病例组,按照请奥加兰(Orgaran,ORG)治疗急性脑卒中临床研究(Trial of ORG 10172 in acute stroke treatment,TOAST)分型对病例组进行分组:A组(n=82)为大动脉粥样硬化组,B组(n=33)为心源性栓塞组,C组(n=41)为小动脉闭塞组; 同期体检健康者155例作为对照组; 检测156例病例组和155例体检健康者外周血中CD4+ T细胞、MeCP2表达水平。结果 A组CD4+ T细胞表达水平明显低于B组、C组以及对照组(P<0.05); B组CD4+ T细胞表达水平明显高于C组和对照组(P<0.05)。病例组MeCP2表达水平明显高于对照组(P<0.05); A组MeCP2表达水平明显高于B组、C组和对照组(P<0.05)。CD4+细胞表达水平与A组呈负相关(B=-1.822,P<0.001)。结论 不同急性脑梗死亚型中CD4+T细胞表达水平不一样,对于大动脉粥样硬化型的脑梗死患者CD4+T细胞表达水平下降,而MeCP2表达水平的升高也预示急性脑梗死的风险增大,说明CD4+T细胞表达水平检测对于急性脑梗死的分型具有一定的意义,而MeCP2表达水平的变化可以作为预防急性脑梗死的重要指标。
Abstract:
ObjectiveTo explore the levels of regulatory T cells and methyl-CpG-binding protein 2(MeCP2)in patients with different types of acute stroke.Methods 156 patients with acute cerebral infarction between February 2017 to February 2019 were enrolled in this study. The patients were classified based on the TOAST(Trial of ORG 10172 in Acute Stroke Treatment)classification. Group A(n=82, large artery atherosclerosis), group B(n=33, cardiogenic embolism)and group C(n=41, small artery occlusion). 155 healthy subjects were enrolled as the control group. The number of CD4+ T cells and the expression levels MeCP2 in the peripheral blood were analyzed.Results The number CD4+ T cells in group A were significantly lower than those in group B, group C, and the control group(P<0.05); The number of CD4+ T cells in group B were significantly higher than those in group C and control group(P<0.05). The MeCP2 expression levels in stroke patients were significantly higher than the control subjects(P<0.05); the MeCP2 levels of group A were significantly higher than that of group B, group C, and the control group(P<0.05).Conclusion The number of CD4+ T cells and the levels of MeCP2 varies in different acute stroke subtypes. They may facilitate the classification of acute cerebral infarction.

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更新日期/Last Update: 2021-04-20