[1]张展舆 张飘 何郴涛 李彦 聂坤 邱轶慧 王丽敏 王丽娟 张玉虎.血脂水平与帕金森病运动障碍及认知功能障碍的研究[J].卒中与神经疾病杂志,2021,28(04):436-440.[doi:10.3969/j.issn.1007-0478.2021.04.012]
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血脂水平与帕金森病运动障碍及认知功能障碍的研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第28卷
期数:
2021年04期
页码:
436-440
栏目:
论著
出版日期:
2021-08-24

文章信息/Info

文章编号:
1007-0478(2021)04-0436-05
作者:
张展舆 张飘 何郴涛 李彦 聂坤 邱轶慧 王丽敏 王丽娟 张玉虎
关键词:
帕金森病 血脂 运动障碍 认知功能障碍
分类号:
R742.5
DOI:
10.3969/j.issn.1007-0478.2021.04.012
文献标志码:
A
摘要:
目的 探讨不同血脂水平在帕金森病(Parkinson’s disease, PD)运动障碍及认知功能障碍中的临床意义,以期对PD的预防及治疗提供理论基础。方法 收集2009年2月-2020年9月在广东省人民医院神经内科就诊的PD患者225例以及选取年龄、性别相匹配的健康对照者100例; 根据Hoehn-Yahr(H-Y)分级评估对PD患者进行分组,早期PD患者160例与中晚期PD患者65例; 根据2012年MDS推荐的PD轻度认知功能障碍(PD mild cognitive impairment, PD-MCI)诊断标准中的Level Ⅰ标准分为帕金森病认知功能正常(Parkinson disease with normal cognition, PD-NC)组86例和PD轻度认知功能障碍组139例; 测定各组总胆固醇(Total cholesterol, TC)、甘油三酯(Triglyceride, TG)、高密度脂蛋白胆固醇(High-density lipoprotein cholesterol, HDL-C)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol, LDL-C)的水平。结果 PD组TC,TG,HDL-C,LDL-C水平显著低于对照组(TC, HDL-C,LDL-C: P<0.01; TG: P=0.026),Logistic回归分析显示TG,HDL-C,LDL-C水平的降低是PD发生的危险因素(TG: P=0.003, HDL-C: P<0.01, LDL-C: P=0.021),但血脂水平不是PD运动障碍加重的影响因素(P>0.05),而TG水平升高是PD-MCI的危险因素(P=0.021)。结论 血脂TG,HDL-C,LDL-C水平的降低可能与PD的发生有关; PD运动障碍进展可能不受血脂水平的影响,而TG水平升高可能与PD-MCI的发生有关。维持一定水平的TG,HDL-C,LDL-C可预防PD的发生,但PD患者需要适度控制TG水平以延缓PD-MCI的发生。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(No.82071419); 广州市民生科技攻关计划(No. 201803010085); 高水平医院建设项目(No.DFJH201907); 广东省杰出青年医学人才项目(No.KJ012019442); 国家重点研发计划资助项目(No. 2017YFC1310200); 广东省医学科研基金项目(No. A2019141, No.A2018036)
作者单位:510006 广州,华南理工大学医学院[张展舆 张玉虎(通信作者)]; 广东省人民医院(广东省医学科学院)神
更新日期/Last Update: 1900-01-01