[1]冯毅 蔡冰 王峰.血清Tau蛋白、巨噬细胞炎症蛋白-1α水平变化与重症高血压性脑出血患者临床结局的相关性分析[J].卒中与神经疾病杂志,2022,29(01):27-32.[doi:10.3969/j.issn.1007-0478.2022.01.005]
　Feng Yi,Cai Bing,Wang Feng.Correlation analysis of serum tau protein, macrophage inflammatory protein-1α and clinical outcome of patients with severe hypertensive intracerebral hemorrhage[J].Stroke and Nervous Diseases,2022,29(01):27-32.[doi:10.3969/j.issn.1007-0478.2022.01.005]
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血清Tau蛋白、巨噬细胞炎症蛋白-1α水平变化与重症高血压性脑出血患者临床结局的相关性分析()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第29卷
期数:
2022年01期
页码:
27-32
栏目:
论 著
出版日期:
2022-02-15

文章信息/Info

Title:
Correlation analysis of serum tau protein, macrophage inflammatory protein-1α and clinical outcome of patients with severe hypertensive intracerebral hemorrhage
文章编号:
1007-0478(2022)01-0027-06
作者:
冯毅 蔡冰 王峰
714000 陕西省渭南市中心医院神经外科(冯毅 王峰),病理科(蔡冰)
Author(s):
Feng Yi;  Cai Bing;  Wang Feng
*Department of Neurosurgery, Weinan Central Hospital, Weinan Shanxi 714000
关键词:
脑出血 高血压病 Tau蛋白 巨噬细胞炎症蛋白-1α Kaplan-Meier生存曲线
Keywords:
Cerebral hemorrhage Hypertension Tau protein Macrophage inflammatory protein-1α Kaplan-Meier survival curve
分类号:
R743.34
DOI:
10.3969/j.issn.1007-0478.2022.01.005
文献标志码:
A
摘要:
目的 探讨血清Tau蛋白、巨噬细胞炎症蛋白-1α(Macrophage inflammatory protein-1α,MIP-1α)水平变化与重症高血压性脑出血(Hypertensive intracerebral hemorrhage,HICH)患者临床结局的相关性。方法 选取2018年10月-2020年10月医院收治的重症HICH患者82例作为研究组,同期以性别、年龄等为匹配条件招募医院体检中心健康志愿者46例作为对照组; 采用双抗体夹心酶联免疫吸附法(Double antibody sandwich enzyme-linked immunosorbent assay,DAS-ELISA)检测所有受试者血清Tau蛋白、MIP-1α水平; 根据受试者工作特征曲线(Receiver operator characteristic curve,ROC)判定血清Tau蛋白、MIP-1α的界限值; 随访患者至2021年4月,采用Kaplan-Meier法及COX比例风险模型多因素分析血清Tau蛋白、MIP-1α表达水平与重症HICH患者临床结局的关系。结果 研究组血清Tau蛋白、MIP-1α水平均高于对照组(P<0.05)。ROC显示,患者血清Tau蛋白、MIP-1α的最佳截断点分别为216.438 pg/mL、84.561 ng/L,其曲线下面积(Area under curve,AUC)分别为0.743和0.737; 入院时GCS评分≥8分、血肿未破入脑室、Tau蛋白表达水平<216.438 pg/mL、MIP-1α表达水平<84.561 ng/L、出院时GOS评分≥3分患者平均生存时间均高于入院时GCS评分<8分、血肿破入脑室、Tau蛋白表达水平≥216.438 pg/mL、MIP-1α表达水平≥84.561 ng/L、出院时GOS评分<3分患者(P<0.05); Kaplan-Meier生存曲线显示,血清Tau蛋白表达水平≥216.438 pg/mL、MIP-1α表达水平≥84.561 ng/L患者与Tau蛋白表达水平<216.438 pg/mL、MIP-1α表达水平<84.561 ng/L患者的生存曲线有明显差异(P<0.05)。COX多因素分析显示,是否破入脑室、Tau蛋白表达水平、MIP-1α表达水平均是影响HICH患者临床结局的相关因素(P<0.05)。结论 重症HICH患者血清Tau蛋白、MIP-1α较健康人呈高表达水平,与患者临床结局关系密切,可作为预测患者临床结局的有效指标。
Abstract:
Objective To investigate the correlation between serum tau protein, macrophage inflammatory protein-1α(MIP-1α)and the clinical outcome of patients with severe hypertensive intracerebral hemorrhage(HICH).Methods A total of 82 patients with severe HICH admitted to the hospital from October 2018 to October 2020 were selected as the research group. During the same period, 46 healthy volunteers from the hospital physical examination center were recruited as the control group based on gender and age as matching conditions. A double antibody sandwich enzyme-linked immunosorbent assay(DAS-ELISA)was used to detect serum tau protein and MIP-1α levels in all subjects. Determine the limit value of serum tau protein and MIP-1α according to the receiver operating characteristic(ROC)curve. The patients were followed up to April 2021, and the relationship between serum tau protein and MIP-1α expression levels and the clinical outcome of severe HICH patients was analyzed by Kaplan-Meier method and Cox proportional hazard model multivariate analysis.Results The levels of serum tau protein and MIP-1α in the study group were higher than those in the control group(P<0.05). The ROC curve showed that the best cut-off points of the patient’s serum tau protein and MIP-1α were 216.438 pg/mL and 84.561 ng/L, respectively, and the AUC were 0.743 and 0.737, respectively. Univariate analysis showed that GCS score ≥8 at admission, hematoma did not break into the ventricle, tau protein expression level <216.438 pg/mL, MIP-1α expression level <84.561 ng/L, and GOS score ≥3 at discharge. The survival time was higher than that of patients with GCS score <8 at admission, hematoma breaking into the ventricle, tau protein expression level ≥216.438 pg/mL, MIP-1α expression level ≥84.561 ng/L, and GOS score at discharge <3 points(P<0.05). COX multivariate analysis showed that whether it broke into the brain ventricle, the expression level of tau protein, and the level of MIP-1α expression were related factors affecting the clinical outcome of HICH patients(P<0.05).Conclusion Serum tau protein and MIP-1α expression levels in severe HICH patients are higher than those in healthy people, which are closely related to the clinical outcome of patients and can be used as effective indicators to predict the clinical outcome of patients.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基金(编号为2019-z-439)
更新日期/Last Update: 1900-01-01