参考文献/References:
[1] Definition FE, Classification. Pathophysiology,and epidemiology[J]. Semin Neurol, 2020, 40(6): 617-623.
[2] Righes MJ, Vendramin PM, Calcagnotto ME. GABAergic interneurons in epilepsy: More than a simple change in inhibition[J]. Epilepsy Behav, 2021, 121(Pt B): 106935.
[3] Kwan P, Brodie MJ. Refractory epilepsy: mechanisms and solutions[J]. Expert Rev Neurother, 2006, 6(3): 397-406.
[4] Tan TH, Perucca P, O’brien TJ, et al. Inflammation, ictogenesis, and epileptogenesis: An exploration through human disease[J]. Epilepsia, 2021, 62(2): 303-324.
[5] Hiragi T, Ikegaya Y, Koyama R. Microglia after Seizures and in Epilepsy[J]. Cells, 2018, 7(4): 26.
[6] Eyo UB, Murugan M, Wu LJ. Microglia-Neuron communication in epilepsy[J]. Glia, 2017, 65(1): 5-18.
[7] Kilkenny C, Browne WJ, Cuthill IC, et al. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research[J]. PLoS Biol, 2010, 8(6): e1000412.
[8] Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure[J]. Electroencephalogr Clin Neurophysiol, 1972, 32(3): 281-294.
[9] Hendrickxd AE, Van Eden CG, Schuurrman KG, et al. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology [J]. Journal of neuroimmunology, 2017, 309(7): 12-22.
[10] Boer K, Spliet WG, Van RP, et al. Evidence of activated microglia in focal cortical dysplasia[J]. J Neuroimmunol, 2006, 173(1/2): 188-195.
[11] Avignone E, Ulmann L, Levavasseur F, et al. Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling[J]. J Neurosci, 2008, 28(37): 9133-9144.
[12] Kinoshita S, Koyama R. Pro- and anti-epileptic roles of microglia[J]. Neural Regen Res, 2021, 16(7): 1369-1371.
[13] Corvace F, Faustmann TJ, Faustmann PM, et al. Anti-inflammatory properties of lacosamide in an astrocyte-microglia co-culture model of inflammation [J]. European journal of pharmacology, 2021: 174696.
[14] Victor TR, Tsirka SE. Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy[J]. Neuroimmunol Neuroinflamm, 2020, 7(2): 234-247.
[15] Andoh M, Ikegaya Y, Koyama R. Synaptic pruning by microglia in epilepsy[J]. J Clin Med, 2019, 8(12): 2170.
[16] Somani A, El-Hachami H, Patodia S, et al. Regional microglial populations in central autonomic brain regions in SUDEP[J]. Epilepsia, 2021, 62(6): 1318-1328.
[17] Cheng H, Wang Y, Chen J, et al. The piriform cortex in epilepsy: What we learn from the kindling model[J]. Exp Neurol, 2020, 324(37): 113137.
[18] Koepp M, Galovic M. Functional imaging of the piriform cortex in focal epilepsy[J]. Exp Neurol, 2020, 330(5): 113305.
[19] L?cher W, Ebert U. The role of the piriform cortex in kindling[J]. Prog Neurobiol, 1996, 50(5/6): 427-481.
[20] Williams D. The thalamus and epilepsy[J]. Brain, 1965, 88(3): 539-556.
[21] Salanova V. Deep brain stimulation for epilepsy[J]. Epilepsy Behav, 2018, 88S(4): 21-24.
[22] Maceachern SJ, Santoro JD, Hahn KJ, et al. Children with epilepsy demonstrate macro- and microstructural changes in the thalamus, putamen, and amygdala[J]. Neuroradiology, 2020, 62(3): 389-397.
[23] Zhang X, Ju G, Le Gal La Salle G. Fos expression in GHB-induced generalized absence epilepsy in the thalamus of the rat[J]. Neuroreport, 1991, 2(8): 469-472.
[24] Wicker E, Forcelli PA. Optogenetic activation of the reticular nucleus of the thalamus attenuates limbic seizures via inhibition of the midline thalamus[J]. Epilepsia, 2021, 62(9): 2283-2296.
[25] Wicker E, Forcelli PA. Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures[J]. Exp Neurol, 2016, 283(Pt A): 404-412.
[26] Zhang DX, Bertram EH. Suppressing limbic seizures by stimulating medial dorsal thalamic nucleus: factors for efficacy[J]. Epilepsia, 2015, 56(3): 479-488.
[27] Druga R, Mares P, Otáhal J, et al. Degenerative neuronal changes in the rat thalamus induced by status epilepticus at different developmental stages[J]. Epilepsy Res, 2005, 63(1): 43-65.