[1]何妮,易兴阳.CYP2C8,GPIIIa和P2Y12变异体之间的相互作用增加了缺血性脑卒中的易感性[J].卒中与神经疾病杂志,2022,29(04):359-364,368.[doi:10.3969/j.issn.1007-0478.2022.04.011]
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CYP2C8,GPIIIa和P2Y12变异体之间的相互作用增加了缺血性脑卒中的易感性()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第29卷
期数:
2022年04期
页码:
359-364,368
栏目:
论著
出版日期:
2022-09-10

文章信息/Info

文章编号:
1007-0478(2022)04-0359-07
作者:
何妮易兴阳
618000 四川省德阳市人民医院神经内科
关键词:
缺血性脑卒中基因多态性细胞色素P450血小板膜受体糖蛋白
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2022.04.011
文献标志码:
A
摘要:
目的 探讨15种基因变异型与缺血性脑卒中(Ischemic stroke,IS)易感性的关系。方法 检测缺血性脑卒中患者和正常人群细胞色素P450(Cytochrome P450,CYP)3A4,CYP3A5,CYP2C8,CYP2C9,CYP2C19、血小板膜受体(Platelet membrane receptor,P)2Y12、P2Y1和糖蛋白IIIa(Glycoprotein IIIa,GPIIIa)基因的15个变异型,通过广义多因子降维法(Generalized multi factor dimensionality reduction meehod,GMDR)分析基因-基因的相互作用。结果 单基因分析方法显示15种变异型在IS患者和对照组之间没有明显差异(P>0.05)。GMDR分析发现rs17110453A>C, rs2317676A>G和rs16863323C>T基因之间有显著的相互协同作用,交叉验证一致性10分,符号测试9分(P=0.016)。逻辑回归分析显示校正年龄、高血压病、糖尿病和糖化血红蛋白A1C(Glycosylated hemoglobin A1C,A1C)等因素后含有rs17110453A>C,rs2317676A>G和rs16863323C>T变异型的个体是预测IS发病的独立危险因素(OR=2.24, 95% CI=1.17~5.62,P=0.005)。结论 rs17110453A>C, rs2317676A>G和rs16863323C>T 3个基因位点的相互作用可能导致IS的发生风险更高。

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更新日期/Last Update: 2022-09-10