[1]唐燕娇,吴京展,张永全,等.急性缺血性脑卒中患者的血清UCP2,HIF-1α水平变化及其临床意义[J].卒中与神经疾病杂志,2023,30(01):59-62,92.[doi:10.3969/j.issn.1007-0478.2023.01.010]
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急性缺血性脑卒中患者的血清UCP2,HIF-1α水平变化及其临床意义()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第30卷
期数:
2023年01期
页码:
59-62,92
栏目:
论著
出版日期:
2023-03-20

文章信息/Info

文章编号:
1007-0478(2023)01-0059-05
作者:
唐燕娇吴京展张永全古嫱芳
530001 南宁,广西中医药大学研究生院(唐燕娇); 广西医科大学第二附属医院[吴京展(通信作者)古嫱芳(广西中医药大学研究生院)]; 广西中医药大学附属瑞康医院(张永全)
关键词:
急性缺血性脑卒中 解偶联蛋白2 缺氧诱导因子1α 预后
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2023.01.010
文献标志码:
A
摘要:
目的 探讨急性缺血性脑卒中(Acute ischemic stroke,AIS)患者血清解偶联蛋白2(Uncoupling protein 2,UCP2)、缺氧诱导因子-1α(Hypoxia-inducible factor-1α,HIF-1α)水平变化及其临床意义。方法 选取123例AIS患者为研究对象(AIS组),以同期61例体检健康的人群为对照组; 采用酶联免疫吸附法检测血清UCP2,HIF-1α水平; 分析血清UCP2,HIF-1α水平与梗死面积、美国国立卫生研究院卒中量表(National institutes of health stroke scale,NIHSS)评分的关系; 多因素Logistic回归分析影响AIS患者预后的因素; 受试者工作曲线(Receiver operating curve,ROC)分析血清UCP2,HIF-1α水平单独及联合检测对AIS预后的预测价值。结果 AIS组血清UCP2水平明显低于对照组(P<0.05); AIS组血清HIF-1α水平明显高于对照组(P<0.05); 不同梗死面积、NIHSS评分AIS患者血清UCP2、HIF-1α水平有明显差异(P<0.05); 梗死面积、NIHSS评分、血清HIF-1α水平是影响AIS患者预后不良的独立危险因素,而血清UCP2水平是保护因素(P<0.05); 血清UCP2,HIF-1α水平单独及联合检测对预测AIS患者预后不良的曲线下面积(Area of the under curve,AUC)分别为0.797、0.786、0.876,联合检测预测AIS患者预后不良的AUC明显大于血清UCP2,HIF-1α水平单独检测(P<0.05)。结论 AIS患者血清UCP2水平降低,HIF-1α水平升高,两者与AIS的病情严重程度和预后有关,联合检测二者水平能提升预后不良的预测价值。

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备注/Memo

备注/Memo:
基金项目:广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211480); 广西壮族自治区中医药管理局自筹经费科研课题(GZZC2020110)
更新日期/Last Update: 2023-03-20