[1]陈洪玉,王舰浩,李易易,等.自噬功能异常与阿尔兹海默病发病机制的研究进展[J].卒中与神经疾病杂志,2023,30(06):626-628.[doi:10.3969/j.issn.1007-0478.2023.06.018 ]
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自噬功能异常与阿尔兹海默病发病机制的研究进展 ()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第30卷
期数:
2023年06期
页码:
626-628
栏目:
综述
出版日期:
2023-12-20

文章信息/Info

文章编号:
1007-0478(2023)06-0626-03
作者:
陈洪玉王舰浩李易易高锋余杭李芳秦冬冬李翔刘松燕王嘉贝张茜王志昊
430060 武汉大学人民医院神经内科和武汉大学人民医院神经退行性疾病研究中心[陈洪玉 王舰浩 李易易 高锋 余杭 李芳 秦冬冬 李翔 刘松燕 王嘉贝 张茜 王志昊(通信作者)]
分类号:
R742
DOI:
10.3969/j.issn.1007-0478.2023.06.018
文献标志码:
A

参考文献/References:

[1] 2023 Alzheimer's disease facts and figures [J].Alzheimer's & Dementia:the Journal of the Alzheimer's Association,2023,19(4):1598-695.
[2] Busche MA,Hyman BT.Synergy between amyloid-β and tau in Alzheimer's disease[J].Nat Neurosci,2020,23(10):1183-1193.
[3] Klionsky DJ,Petroni G,Amaravadi RK,et al.Autophagy in major human diseases[J].EMBO J,2021,40(19):e108863.
[4] Lee JH,Yang DS,Goulbourne CN,et al.Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques[J].Nat Neurosci,2022,25(6):688-701.
[5] Xu Y,Propson NE,Du SQ,et al.Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading[J].Proc Natl Acad Sci U S A,2021,118(27):e2023418118.
[6] Scrivo A,Bourdenx M,Pampliega O,et al.Selective autophagy as a potential therapeutic target for neurodegenerative disorders[J].Lancet Neurol,2018,17(9):802-815.
[7] Russell RC,Tian Y,Yuan HX,et al.ULK1 induces autophagy by phosphorylating beclin-1 and activating VPS34 lipid kinase[J].Nat Cell Biol,2013,15(7):741-750.
[8] Nishimura T,Tamura N,Kono N,et al.Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains[J].EMBO J,2017,36(12):1719-1735.
[9] Agrotis A,Pengo N,Burden JJ,et al.Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells[J].Autophagy,2019,15(6):976-997.
[10] Jiang RC,Shimozawa M,Mayer J,et al.Autophagy impairment in App knock-in Alzheimer's model mice[J].Front Aging Neurosci,2022,14:878303.
[11] Wani A,Al Rihani SB,Sharma A,et al.Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[J].Autophagy,2021,17(11):3813-3832.
[12] Wang BJ,Her GM,Hu MK,et al.ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease[J].Proc Natl Acad Sci U S A,2017,114(15):E3129-E3138.
[13] Cai CZ,Zhuang XX,Zhu Q,et al.Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer's disease models[J].Theranostics,2022,12(4):1738-1755.
[14] Cai CZ,Yang C,Zhuang XX,et al.NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation[J].Autophagy,2021,17(5):1112-1130.
[15] Lachance V,Wang Q,Sweet E,et al.Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice[J].Mol Neurodegener,2019,14(1):43.
[16] Shirotani K,Watanabe K,Hatta D,et al.Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients[J].Genes Cells,2023,28(4):319-325.
[17] Chen JF,Long ZM,Li YZ,et al.Alteration of the Wnt/GSK3β/β-catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model[J].Int J Mol Med,2019,44(1):313-323.
[18] Zhu ZK,Liu YX,Li XY,et al.GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal[J].Neurosci Lett,2022,767:136300.
[19] Wang HJ,Wang RZ,Xu SH,et al.Transcription factor EB is selectively reduced in the nuclear fractions of Alzheimer's and amyotrophic lateral sclerosis brains[J].Neurosci J,2016,2016:4732837.
[20] Yamamoto F,Taniguchi K,Mamada NM,et al.TFEB-mediated enhancement of the autophagy-lysosomal pathway dually modulates the process of amyloid β-protein generation in neurons[J].Neuroscience,2019,402:11-22.
[21] Sreenivasmurthy SG,Iyaswamy A,Krishnamoorthi S,et al.Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy[J].Front Mol Biosci,2022,9:1030534.
[22] Ji CY,Tang MP,Zeidler C,et al.BAG3 and SYNPO(synaptopodin)facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes[J].Autophagy,2019,15(7):1199-1213.
[23] Fu HJ,Possenti A,Freer R,et al.A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology[J].Nat Neurosci,2019,22(1):47-56.
[24] Bourdenx M, Martin-Segura A,Scrivo A,et al.Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome [J].Cell,2021,184(10):2696-714,e25.
[25] Fang CX,Woo JAA,Liu T,et al.SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance Independent of CFL(cofilin)activation[J].Autophagy,2021,17(9):2144-2165.
[26] Cazzaro S,Fang CX,Khan H,et al.Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics[J].Front Aging Neurosci,2022,14:933979.
[27] Polanco JC,Hand GR,Briner A,et al.Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol[J].Acta Neuropathol,2021,141(2):235-256.
[28] Sampognaro PJ,Arya S,Knudsen GM,et al.Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases[J].Mol Neurodegener,2023,18(1):29.
[29] Li MZ,Liu EJ,Zhou QZ,et al.Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling[J].Mil Med Res,2022,9(1):38.
[30] Tong BCK,Huang AS,Wu AJ,et al.Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies[J].J Biomed Sci,2022,29(1):85.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年科学基金项目(82101479); 国家重点研究计划项目(2021YFA1302400); 湖北省实验动物研究领域项目(2022DFE021); 武汉大学人民医院交叉创新人才项目(JCRCZN-2022-002)
更新日期/Last Update: 2023-12-20