[1]文萍,毛善平.TIA及轻型脑梗死患者风险决策功能特点研究[J].卒中与神经疾病杂志,2025,32(02):151-157.[doi:10.3969/j.issn.1007-0478.2025.02.008]
　Wen Ping,Mao Shanping..A study on the functional characteristics of risk decision-making in patients with TIA and mild ischemic stroke[J].Stroke and Nervous Diseases,2025,32(02):151-157.[doi:10.3969/j.issn.1007-0478.2025.02.008]
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TIA及轻型脑梗死患者风险决策功能特点研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第32卷
期数:
2025年02期
页码:
151-157
栏目:
论著
出版日期:
2025-04-20

文章信息/Info

Title:
A study on the functional characteristics of risk decision-making in patients with TIA and mild ischemic stroke
文章编号:
1007-0478(2025)02-0151-07
作者:
文萍; 毛善平
430060 武汉大学人民医院神经内科[文萍 毛善平(通信作者)]
Author(s):
Wen Ping;  Mao Shanping.
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060
关键词:
短暂性脑缺血发作 缺血性脑血管病 风险决策 认知功能 骰子博弈任务
Keywords:
Transient ischemic attack Ischemic cerebrovascular disease Risky decision-making Cognitive function Game of Dice Task
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2025.02.008
文献标志码:
A
摘要:
目的 探讨短暂性脑缺血发作(Transient ischemic attack,TIA)及轻型脑梗死(Minor ischemic stroke,MIS)患者风险决策功能的特点。方法 通过简易精神状态检查(Mini-mental state examination, MMSE)、蒙特利尔认知评估(Montreal cognitive assessment, MOCA)、画钟试验(Clock drawing test, CDT)、语言流畅性测试(Verbal fluency task, VFT)、贝克抑郁量表(Beck depression inventory, BDI)和贝克焦虑量表(Beck anxiety inventory, BAI)评估41例TIA或MIS患者以及与其年龄、性别和教育水平相当的38名健康受试者的整体认知功能状况、执行能力、语言能力以及焦虑和抑郁水平; 通过骰子博弈任务(Game of dice test,GDT)来评估这些参与者在面临风险时的决策能力。结果 TIA/MIS组在GDT任务中更倾向于选择风险选项(t=4.822,P<0.001),特别是1个数字(t=3.683,P<0.001); TIA/MIS组最终总收益也明显低于健康对照组(t=-4.596,P<0.001),相比而言,健康对照组的负反馈利用率更高(t=-5.681,P<0.001),即在经受风险选项失利的惩罚后更容易转投安全选项; TIA/MIS组内分析显示前循环供血区脑梗死(Partial anterior circulation infarct,PACI)组和后循环供血区脑梗死(Posterior circulation infarct,POCI)组在GDT最终总收益上无明显差异(P>0.05)。结论 TIA/MIS患者在风险明确的条件下更容易选择风险选项,且对负面损失的敏感度较差; 后循环供血区在风险决策中具有和前循环供血区相当的重要作用。
Abstract:
ObjectiveTo investigate the characteristics of risk decision-making function in patients with Transient ischemic attack(TIA)and Minor ischemic stroke(MIS).Methods 41 participants with TIA or MIS(hereinafter referred to as TIA/MIS)and 38 healthy subjects of comparable age, gender and education level were assessed by the Mini-mental state examination(MMSE), Montreal cognitive assessment(MOCA), Clock drawing test(CDT), Verbal fluency task(VFT), Beck depression inventory(BDI)and Beck anxiety inventory(BAI). These tests were used to assess participants' overall cognitive status, executive functioning, verbal ability, and anxiety and depression levels. The Game of dice test(GDT)was used to assess the decision-making ability of these participants when faced with risk.Results The TIA/MIS group was more inclined to choose the risky option in the GDT task(t=4.822, P<0.001), especially for 1 number(t=3.683, P<0.001), and the final total gain of the TIA/MIS was significantly lower than that of the healthy control group (t=-4.596, P<0.001). In contrast, the healthy control group were more likely to switch to the safe option after being penalized for losing the risky option, with a higher utilization of negative feedback(t=-5.681, P<0.001). TIA/MIS within-group analysis showed no significant difference between the PACI group and the POCI group in terms of final total GDT gain(P>0.05).Conclusion Patients with TIA/MIS were more likely to choose the risky option under conditions where the risk was clear and were less sensitive to negative losses than the healthy population. The post-circulation blood supply area plays an equally important role in risk decision-making as the pre-circulation blood supply area.

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备注/Memo

备注/Memo:
基金项目:湖北省重点研发计划专项(2022BCA029)
更新日期/Last Update: 2025-04-20