[1]施静静,陈涛,刘毅,等.DEC1、LXRβ在动脉硬化性脑梗死患者血清中的水平及其临床意义[J].卒中与神经疾病杂志,2017,24(01):24-26+37.[doi:10.3969/j.issn.1007-0478.2017.01.006]
　Shi Jingjing,Chen Tao,Liu Yi,et al.The expression of serum DEC1 and LXRβ in atherosclerotic cerebral infarction and its clinical significance[J].Stroke and Nervous Diseases,2017,24(01):24-26+37.[doi:10.3969/j.issn.1007-0478.2017.01.006]
点击复制

DEC1、LXRβ在动脉硬化性脑梗死患者血清中的水平及其临床意义()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第24卷
期数:
2017年01期
页码:
24-26+37
栏目:
论 著
出版日期:
2017-02-26

文章信息/Info

Title:
The expression of serum DEC1 and LXRβ in atherosclerotic cerebral infarction and its clinical significance
文章编号:
1007-0478(2017)01-0024-04
作者:
施静静; 陈涛; 刘毅; 金泉伟; 王婧蕾; 徐杰
725000 陕西省安康市中心医院神经内科[施静静 陈涛(通信作者)刘毅 金泉伟 王婧蕾 徐杰]
Author(s):
Shi Jingjing;  Chen Tao;  Liu Yi;  et al.
Department of Neurology, Ankang Central Hospital, Ankang 725000
关键词:
脑梗死 分化型胚胎软骨发育基因1 肝X受体β
Keywords:
Stroke Differentiation type embryonic cartilage development genes 1 Liver X receptor β
分类号:
R743.1
DOI:
10.3969/j.issn.1007-0478.2017.01.006
摘要:
目的 探讨分化型胚胎软骨发育基因1(differentiation type embryonic cartilage development genes 1, DEC1)、肝X受体β(Liver X receptor β, LXRβ)在动脉硬化性脑梗死患者血清中的水平及其临床意义。方法 选择2013年3月～2015年12月本院的60例急性脑梗死患者为研究对象,选择2013年3月～2015年12月健康人群60例为对照组,检测入组对象血清DEC1、LXRβ水平。结果 脑梗死组血清DEC1水平高于对照组(P<0.01),脑梗死组血清LXRβ水平低于对照组(P<0.01)。随着脑梗死患者病情的加重,血清DEC1水平呈不断升高趋势(P<0.05); 随着患者功能障碍程度的加重,血清DEC1水平不断升高(P<0.05)。随着急性脑梗死患者脑梗死病情的加重,血清LXRβ水平不断降低(P<0.05); 随着急性脑梗死患者功能障碍程度的加重,血清LXRβ水平不断降低(P<0.05)。急性脑梗死患者血清DEC1水平与LXRβ水平呈负相关(r=-0.331,P=0.009)。结论 DEC1、LXRβ可能参与了急性脑梗死的发病及病情进展,且DEC1可能通过负向调控LXRβ进而在急性脑梗死发病、病情加重、功能障碍程度加重过程中发挥作用。
Abstract:
ObjectiveTo detect the expression of serum differentiation type embryonic cartilage development genes 1(DEC1)and liver X receptor β(LXRβ)in atherosclerotic cerebral infarction, and explore its clinical significance.Methods 60 patients with acute cerebral infarction from March 2011 to December 2015 in our hospital were selected as the research object,and 60 healthy people from March 2013 to December 2015 were selected as control group.The concentration of serum DEC1 and LXRβ in all cases was detected.Results The serum level of DEC1 in acute stroke group was significantly higher than in the control group(P<0.01).The serum level of LXRβ in the acute stroke group was significantly lower than in the control group(P<0.01).With the deterioration of patients' condition,the serum level of DEC1 was rising(P<0.05).When the patients' dysfunction was aggravating,the serum level of DEC1 was rising(P<0.05).With the deterioration of patients' condition,the serum level of LXRβ trended to decrease(P <0.05).As the patients' dysfunction was aggravating,the serum level of LXRβ trended to decrease(P<0.05).The serum level of DEC1in patients with acute stroke had a negative correlation with that of LXRβ(r=-0.331,P=0.009).Conclusion DEC1 and LXRβ are involved in the onset of acute cerebral infarction and its progression.DEC1 plays a role in the pathogenesis of acute cerebral infarction,its deteriorating process and the aggravation of patients' dysfunction through negatively regulating LXRβ.

参考文献/References:

[1] Jiao L,Chu C,Zhou S.Prognostic value of copeptin in patients with acute stroke[J].Expert Rev Neurother,2015,15(5):563-570.
[2] 华威,吴鹤,周敏,等.重组人促红细胞生成素对脑梗死后少突胶质细胞的保护作用[J].中华病理学杂志,2015,44(5):323-328.
[3] 张亚,刘艺,王珊珊,等.脑梗死后脑水肿的研究进展[J].中华老年心脑血管病杂志,2015,17(3):331-333.
[4] 陈佳,梁燕玲,郑翾,等.超声介导微泡携带激肽原酶靶向治疗技术对实验性急性脑梗死后神经再生及血管新生的影响[J].中华神经科杂志,2015,48(1):55-60.
[5] 张媚,熊莉君,喻小红.初发脑梗死患者同型半胱氨酸、白细胞介素-1β、肿瘤坏死因子-α水平与并发焦虑抑郁状态的相关性研究[J].中华实验外科杂志,2014,31(4):887-888.
[6] Krupinski J,Kaluza J,Kumar P,et al.Role of angiogenesis in patients with cerebral ischemic stroke[J].Stroke,1994,25(9):1794-1798.
[7] 中华医学会神经病学分会.中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8] Helbok R,Schiefecker AJ,Beer R,et al.Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study[J].Crit Care,2015,19(1):75.
[9] 龚如,万杰清,樊翊凌,等.急性脑梗死患者外周血内皮祖细胞水平变化及其临床意义[J].中华创伤杂志,2014,30(7):725-729.
[10] 孔德燕.腔隙性脑梗死患者脑微出血与循环内皮微粒的相关性研究[J].中华老年心脑血管病杂志,2015,17(6):610-612.
[11] Seino H,Wu YY,Morohashi S,et al.Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells[J].Biomedical Research-Tokyo,2015,36(2):89-96.
[12] Sato F,Muragaki Y,Zhang Y.DEC1 negatively regulates AMPK activity via LKB1[J].Biochem Biophys Res Commun,2015,467(4):711-716.
[13] Nomura S,Endo-Umeda K,Aoyama A,et al.Styrylphenylphthalimides as novel Transrepression-Selective liver X receptor(LXR)modulators[J].ACS Med Chem Lett,2015,6(8):902-907.
[14] Nian S,Gan X,Tan X,et al.Discovery and synthesis of a novel series of liver X receptor antagonists[J].Chem Pharm Bull(Tokyo),2015,63(8):628-635.
[15] Kim CY,Lee JS,Kim HD,et al.Lower extremity muscle activation and function in progressive task-oriented training on the supplementary tilt table during stepping-like movements in patients with acute stroke hemiparesis[J].J Electromyogr Kinesiol,2015,25(3):522-530.

更新日期/Last Update: 2017-02-20