[1]贺文涛,耿纪超.缺血性脑卒中患者血浆microRNA-23a/30a水平变化及其临床意义[J].卒中与神经疾病杂志,2018,25(03):281-283+297.[doi:10.3969/j.issn.1007-0478.2018.03.010]
　He Wentao*,Geng Jichao..Expression level changes and clinical significance of plasma mirnas-23a/30a in Ischemic cerebral apoplexy patients[J].Stroke and Nervous Diseases,2018,25(03):281-283+297.[doi:10.3969/j.issn.1007-0478.2018.03.010]
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缺血性脑卒中患者血浆microRNA-23a/30a水平变化及其临床意义()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第25卷
期数:
2018年03期
页码:
281-283+297
栏目:
论 著
出版日期:
2018-06-26

文章信息/Info

Title:
Expression level changes and clinical significance of plasma mirnas-23a/30a in Ischemic cerebral apoplexy patients
文章编号:
1007-0478(2018)03-0281-04
作者:
贺文涛; 耿纪超
451200 河南巩义瑞康医院神经内科(贺文涛); 河南省直第三人民医院神经内科(耿纪超)
Author(s):
He Wentao*;  Geng Jichao.
*Department of Neurology, the Ruikang Hospital of Gongyi, Gongyi Henan 451200
关键词:
缺血性脑卒中 microRNA-23a/30a 生物标志物
Keywords:
Ischemic stroke Micrornas-23a/30a Biomarkers
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2018.03.010
文献标志码:
A
摘要:
目的 探讨缺血性脑卒中患者的血浆microRNA-23a/30a表达水平变化及其临床意义。方法 采用病例对照研究,选取本院神经内科自2014年7月-2015月7月收治的40例缺血性脑卒中患者作为研究对象,根据入院病情分为轻型组和重型组,选取同期20例性别、年龄相匹配的体检健康者作为对照组; 采用实时荧光定量聚合酶链反应(PCR)检测入选者外周循环血microRNA-23a/30a的表达水平。结果 入院时重型组血浆miRNA-23a/30a水平与轻型组对照组比较有明显差异(P<0.05); 轻型组和重型组不同时间点的血浆microRNA-23a/30a水平进行比较,也均有明显差异(P<0.05); 治疗1周后血浆microRNA-23a/30a水平与病情严重程度进行Spearman秩相关的非参数分析显示,血浆microRNA-23a/30a水平与病情严重程度呈正相关(r=0.917,P<0.05)。结论 外周血miRNA-23a/30a表达水平与缺血性脑卒中关系密切,有望成为缺血性脑卒中患者的病情严重程度和发病风险预测的一个重要的客观生物标志物。
Abstract:
ObjectiveTo investigate expression level changes and clinical significance of plasma mirnas-23a/30a in Ischemic cerebral apoplexy patients.Methods By case-control study method, 40 ischemic cerebral apoplexy patients were selected as the research objects from July 2014 to July 2015. According to the Patient's condition, they were divided into mild and severe group. 20 cases physical healthy subjects were selected as control group.There were the same gender and age in two groups. By real-time fluorescent quantitative PCR method, peripheral blood micrornas-23a/30a expression levels of two groups were detected, the correlation was analyzed.Results On admission, expression level of plasma mirnas-23a/30a in the mild and severe group was compared with that in the mild group and the control group, the difference was statistically significant(P<0.05). Expression levels of plasma mirnas-23a/30a of the mild and severe group in the different time had a comparison, the difference was statistically significant(P<0.05). After the patients were treated for 1 weeks, expression levels of plasma mirnas-23a/30a of the mild and severe group had a correlation analysis, it showed that they were positively correlated(r=0.917, P<0.05).Conclusion expression levels of plasma mirnas- 23a/30a was closely associated with ischemic brain stroke, it was expected to become an important objective of biomarkers for the ischemic cerebral apoplexy disease severity and risk prediction.

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更新日期/Last Update: 2018-06-20