参考文献/References:
[1] Das S,Kaul S,Jyothy A,et al.Association of APOE(E2, E3 and E4)gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population[J].Neurosci Lett,2016,628(628):136-141.
[2] Blazejewska-Hyzorek B,Gromadzka G,Skowronska M,et al.APOE ε 2 allele is an Independent risk factor for vulnerable carotid plaque in ischemic stroke patients[J].Neurol Res,2014,36(11):950-954.
[3] Mahley RW.Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders[J].Journal of Molecular Medicine-JMM,2016,94(7):739-746.
[4] Papaioannou I,Simons JP,Owen JS.Targeted in situ gene correction of dysfunctional APOE alleles to produce atheroprotective plasma ApoE3 protein[J].Cardiol Res Pract,2012,2012:148796.
[5] Lee Y,Kockx M,Raftery MJ,et al.Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry:evidence for a novel site of glycosylation on Ser290[J].Mol Cell Proteomics,2010,9(9):1968-1981.
[6] Mahley RW,Weisgraber KH,Huang Y.Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS[J].J Lipid Res,2009,50(Suppl):S183-S188.
[7] Lopez MF,Krastins B,Ning M.The role of apolipoprotein E in neurodegeneration and cardiovascular disease[J].Expert Rev Proteomics,2014,11(3):371-381.
[8] Mahley RW,Rall SC.Apolipoprotein E: far more than a lipid transport protein[J].Annu Rev Genomics Hum Genet,2000,1:507-537.
[9] Li H,Dhanasekaran P,Alexander ET,et al.Molecular mechanisms responsible for the differential effects of ApoE3 and ApoE4 on plasma Lipoprotein-Cholesterol levels[J].Arterioscler Thromb Vasc Biol,2013,33(4):687-U101.
[10] Nguyen D,Dhanasekaran P,Nickel MA,et al.Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4[J].Biochemistry,2010,49(51):10881-10889.
[11] Ni XQ,Zhang JW.Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies[J].PLoS One,2014,9(3):e90255.
[12] Sharma P,Yadav S,Meschia JF.Genetics of ischaemic stroke[J].J Neurol Neurosurg Psychiatry,2013,84(12):1302-1308.
[13] Khan TA,Shah T,Prieto D,et al.Apolipoprotein E genotype,cardiovascular biomarkers and risk of stroke:systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of Primary biomarker data from up to 60,883 individuals.Int J[J].Environment Epidemiology,2013,42(2):475-492.
[14] Polak JF,Pencina MJ,Pencina KM,et al.Carotid-Wall Intima-Media thickness and cardiovascular events[J].N Engl J Med,2011,365(3):213-221.
[15] Yan HQ,Yuan Y,Zhang P,et al.Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations[J].Genet Mol Res,2015,14(1):665-670.
[16] Wang B,Zhao H,Zhou L,et al.Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations:New data and meta-analysis[J].Exp Ther Med,2013,5(3):853-859.
[17] Gu L,Su L,Chen Q,et al.Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis[J].Exp Ther Med,2013,5(3):853-859.
[18] Lai CL,Liu CK,Lin RT,et al.Association of apolipoprotein E polymorphism with ischemic stroke subtypes in Taiwan[J].Kaohsiung J Med Sci,2007,23(10):491-497.
[19] Abboud S,Viiri LE,Lütjohann D,et al.Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis[J].Eur J Hum Genet,2008,16(8):955-960.
[20] Kanekiyo T XH,Aβ in Alzheimer's Disease:Accidental Encounters or Partners? [J].Neuron.,2014,81(4):740-754.
[21] Tai LM,Mehra S,Shete V,et al.Soluble apoE/Aβ complex:mechanism and therapeutic target for APOE4-induced AD risk[Z],2014:2.
[22] Bell RD,Winkler EA,Singh I,et al.Apolipoprotein E controls cerebrovascular integrity via cyclophilin A[J].Nature,2012,485(7399):512-516.
[23] Tai LM,Thomas R,Marottoli FM,et al.The role of APOE in cerebrovascular dysfunction[J].Acta Neuropathol,2016,131(5):709-723.
[24] Tai LM,Ghura S,Koster KP,et al.APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective[J].J Neurochem,2015,133(4):465-488.