参考文献/References:
[1] Yassi N,Desmond PM,Masters CL.Magnetic resonance imaging of vascular contributions to cognitive impairment and dementia[J].J Mol Neurosci,2016,60(3):349-353.
[2] De Silva TM,Faraci FM.Microvascular dysfunction and cognitive impairment[J].Cell Mol Neurobiol,2016,36(2):241-258.
[3] Moran C,Phan TG,Srikanth VK.Cerebral small vessel disease:a review of clinical,radiological,and histopathological phenotypes[J].Int J Stroke,2012,7(1):36-46.
[4] Thompson CS,Hakim AM.Living beyond our physiological means:small vessel disease of the brain is an expres-sion of a systemic failure in arteriolar function:a unifying hypothesis[J].Stroke,2009,40(5):322-330.
[5] Ostergaard L,Engedal TS,Moreton FA,et al.Cerebral small vessel disease:Capillary pathways to stroke and cognitive decline[J].Journal of Cerebral Blood Flow and Metabolism,2016,36(2):302-325.
[6] Schmidt R,Petrovic K,Ropele S,et al.Progression of leukoaraiosis and cognition[J].Stroke,2007,38(9):2619-2625.
[7] Bailey EL,Smith C,Sudlow CL,et al.Pathology of lacunar ischemic stroke in humans:a systematic review[Z],2012:591.
[8] Wardlaw JM,Smith C,Dichgans M.Mechanisms of sporadic cerebral small vessel disease:insights from neuroimaging[J].Lancet Neurol,2013,12(5):483-497.
[9] Ihara M,Yamamoto Y.Emerging evidence for pathogenesis of sporadic cerebral small vessel disease[J].Stroke,2016,47(2):554-560.
[10] Kalaria RN,Akinyemi R,Ihara M.Stroke injury,cognitive impairment and vascular dementia[J].Biochim Biophys Acta,2016,1862(5):915-925.
[11] Chen Y,Wang A,Tang J,et al.Association of white matter integrity and cognitive functions in patients with subcortical silent lacunar infarcts[J].Stroke,2015,46(4):1123-1126.
[12] Helenius J,Henninger N.Leukoaraiosis burden significandy modulate the associatiao between infarct volume and National institutes of health stroke scale in ischemic stroke[J].Stroke,2015,46(7):1857-1863.
[13] Van Dijk EJ,Prins ND,Vrooman HA,et al.Progression of cerebral small vessel disease in relation to risk factors and cognitive Consequences:Rotterdam Scan study[J].Stroke,2008,39(10):2712-2719.
[14] Turk M,Zupan M,Zaletel M,et al.Carotid arterial hemodynamic in ischemic levkoaraiosis suggests hypoperfusion mechanism[J].Eur Neurol,2015,73(5/6):310-315.
[15] Gioia LC,Kate M,Choi V,et al.Ischemia in intracerebral hemorrhage is associated with leukoaraiosis and hematoma volume,not blood pressure reduction[J].Stroke,2015,46(6):1541-1547.
[16] Yan T,Yu JR,Zhang YP,et al.Analysis on correlation of white matter lesion and lacunar infarction with vascular cognitive impairment[J].Int J Clin Exp Med,2015,8(8):14119-14122.
[17] Maniega SM,Valdés Hernández MC,Clayden JD,et al.White matter hyperintensities and normal-appearing white matter integrity in the aging brain[J].Neurobiol Aging,2015,36(2):909-918.
[18] Pavlovic AM,Pekmezovic T,Tomic G,et al.Baseline predictors of cognitive decline in patients with cerebral small vessel disease[J].J Alzheimers Dis,2014,42(Suppl 3):S37-S43.
[19] Prins ND,Scheltens P.White matter hyperintensities,cognitive impairment and dementia:an update[J].Nat Rev Neurol,2015,11(3):157-165.
[20] Yoon B,Shim YS,Cheong HK,et al.White matter hyperintensities in mild cognitive impairment:clinical impact of location and interaction with lacunes and medial temporal atrophy[J].J Stroke Cerebrovasc Dis,2014,23(5):e365-e372.
[21] Cordonnier C,Al-Shahi Salman R,Wardlaw J.Spontaneous brain microbleeds:systematic review,subgroup analyses and standards for study design and reporting[J].Brain,2007,130(Pt 8):1988-2003.
[22] 范玉华,莫仲棠,许志辉,等.腔隙性脑梗塞患者脑内微出血的发生、分布及其意义[J].中国神经精神疾病杂志,2003,29(4):244-248.
[23] Wu Y,Chen T.An Up-to-Date review on cerebral microbleeds[J].J Stroke Cerebrovasc Dis,2016,25(6):1301-1306.
[24] Akoudad S,Wolters FJ,Viswanathan A,et al.Association of cerebral microbleeds with cognitive decline and dementia[J].JAMA Neurol,2016,73(8):934-943.
[25] Wang Z,Wong A,Liu W,et al.Cerebral microbleeds and cognitive function in ischemic stroke or transient ischemic attack patients[J].Dement Geriatr Cogn Disord,2015,40(3/4):130-136.
[26] Thijs V,Lemmens R,Schoofs C,et al.Microbleeds and the risk of recurrent stroke[J].Stroke,2010,41(9):2005-2009.
[27] Gorelick PS.Vascular contributions to cognitive impairment and dementia:a statement for healthcare prolessionals Irom the American heart association/American Stroke association[J].Stroke,2011,42(9):2672-2713.
[28] Chan SL,Sweet JG,Cipolla MJ.Treatment for cerebral small vessel disease:effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertension[J].FASEB J,2013,27(10):3917-3927.