参考文献/References:
[1] Pavese N, Brooks D J. Imaging neurodegeneration in Parkinson's disease[J]. Biochimica et Biophysica Acta-Molecular Basis of Disease, 2009, 1792(7):722-729.
[2] Fritsch T, Smyth K A, Wallendal M S, et al. Parkinson disease: research update and clinical management[J]. Southern Medical Journal, 2012, 105(12):650-656.
[3] Hodaie M, Neimat JS, Lozano AM. The dopaminergicnigrostriatal system anParkinson'sdisease:molecularevents in development,disease,and cell death,and newtherapeutic strategies[J]. Neurosurgery, 2007, 60(1):17-28.
[4] Hu T, Fang XW, Zheng XL. Study on idiopathic Parkinson's disease with 1H-MRS and DTI[J]. Int J Med Radiol, 2011, 34(2):130-134.
[5] 魏欢,战丽萍.氢质子波谱分析在帕金森病中的应用[J].中风与神经疾病杂志,2015,32(9):862-864.
[6] Grger A, Bender B, Wurster I, et al. Differentiation between idiopathic and atypical parkinsonian syndromes using threedimensional magnetic resonance spectroscopic imaging[J]. Journal of Neurology, Neurosurgery, and Psychiatry, 2013, 84(6):644-649.
[7] Metarugcheep P, Hanchaiphiboolkul S, Viriyavejakul A, et al. The usage of proton magnetic resonance spectroscopy in Parkinson's disease[J]. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 2012, 95(7):949-952.
[8] Zhou B, Yuan FZ, He Z, et al. Application of proton magnetic resonance spectroscopy on substantia nigra metabolites in Parkinson's disease[J]. Brain Imaging and Behavior, 2014, 8(1):97-101.
[9] 黄嵘,王翀.早期帕金森患者50例磁共振波谱的临床研究[J].脑与神经疾病杂志,2015,23(2):105-107.
[10] Onu M, Roceanu A, Sboto-Frankenstein U, et al. Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores[J]. European Journal of Radiology, 2012, 81(3):E386-E391.
[11] Sikio M, Kolhi P, Ryymin P, et al. MRI texture analysis and diffusion tensor imaging in chronic right hemisphere ischemic stroke[J]. Journal of Neuroimaging, 2015, 25(4):614-619.
[12] 邢一兰,陈俊抛,苏欢欢.磁共振弥散张量成像在帕金森病早期诊断以及定量分析中的临床应用价值[J].中国现代医学杂志,2015,25(8):43-46.
[13] 石峰,高阳,乔鹏飞,等.扩散张量成像在帕金森病认知障碍中的量化研究[J].磁共振成像,2015,6(5):326-332.
[14] 陈文鑫,邓远飞,吴学良,等.黑质FA值对早期诊断帕金森病的临床研究[J].卒中与神经疾病,2016,23(2):107-109.
[15] Haller S, Badoud S, Nguyen D, et al. Individual detection of patients with Parkinson disease using support vector machine analysis of diffusion tensor imaging data: initial results[J]. AJNR. American Journal of Neuroradiology, 2012, 33(11):2123-2128.
[16] Dresler T, Guhn A, Tupak S V, et al. Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder[J]. Journal of Neural Transmission, 2013, 120(1, SI):3-29.
[17] Yu RJ, Liu B, Wang LL, et al. Enhanced functional connectivity between putamen and supplementary motor area in parkinson's disease patients[J]. PLOS One, 2013, 8(3):e5971701-e5971708.
[18] Sheng K, Fang WD, Su ML, et al. Altered spontaneous brain activity in patients with parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the Prefrontal-Limbic system[J]. PLOS One, 2014, 9(1):e8470501-e8470510.
[19] Pavese N,Rivero-Bosch M,Lewis SJ,et al.Progression of monoaminergic dysfunction in Parkinson's disease:a longitudinal 18Fdopa PET study[J]. Neuroimage, 2011, 56(3):1463-1468
[20] Lin SC,Lin KJ,Hsiao IT. In vivo detection of monoaminergic degeneration in early Parkinson disease by 18F-9-fluoropropyl-(+)-dihydrotetrabenzazinePET[J]. Nucl Med, 2014, 55(1):73-79.
[21] Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series[J]. Sleep Medicine, 2013, 14(8):744-748.
[22] Wu P, Yu H, Peng SC, et al. Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder[J]. Brain, 2014, 137(12):3122-3128.
[23] Wu P, Wang J, Peng S, et al. Metabolic brain network in the Chinese patients with Parkinson's disease based on18F-FDG PET imaging[J]. Parkinsonism & Related Disorders, 2013, 19(6):622-627.
[24] Park J, Chang WH, Cho JW, et al. Usefulness of transcranial magnetic stimulation to assess motor function in patients with parkinsonism[J]. Annals of Rehabilitation Medicine, 2016, 40(1):81-87.
[25] Zhang YC, Hu H, Luo WF, et al. Alteration of brainstem raphe measured by transcranialsonography in depression patients with or without Parkinson's disease[J]. Neurological Sciences, 2016, 37(1):45-50.
[26] Budisic M, Trkanjec Z, Bosnjak J, et al. Distinguishing parkinson's disease and essential tremor with transcranial sonography[J]. Acta Neurologica Scandinavica, 2009, 119(1):17-21.
[27] Bruggink KA, Kuiperij HB, Ekholm-Pettersson F, et al. Detection of elevated levels of α-synuclein oligomers in CSF from paients with Parkinson disease[J]. Neurology, 2010, 77(5):510-510.
[28] Fleming SM, Tetreault NA, Mulligan CK, et al. Olfactory deficits in mice overexpressing human wildtype a-synuclein[J]. European Journal of Neuroscience, 2008, 28(2):247-256.
[29] Ladinska M, Elizabeta B. Parkinson's disease:diagnostic relevance of elevated levels of soluble α-synuclein oligomers in cerebrospinal fluid[J]. Future Neurology, 2011, 6(2):159-163.
[30] Giannoccaro MP, Donadio V, Incensi AA, et al. Skin biopsy and 1-123 MIBG scintigraphy findings in idiopathic parkinson's disease and parkinsonism: a comparative study[J]. Movement Disorders, 2015, 30(7):986-989.
[31] Lamotte G, Morello R, Lebasnier A,et al.Accuracy and cut off values of delayed heart to mediastinum ratio with 123I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses[J]. BMC Neurol, 2015, 15:83-90.
[32] Hoyles K, Sharma JC. Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: a pragmatic approach[J]. Journal of Neurology, 2013, 260(12):2951-2958.
[33] Korten JJ, Meulstee J. Olfactory disturbances in Parkinsonism[J]. Clinical Neurology and Neurosurgery, 1980, 82(2):113-118.
[34] Braak H, Del Tredici K, RÜB U, et al. Staging of brain pathology related to sporadic Parkinson's disease[J]. Neurobiology of Aging, 2002, 24(2):197-211.
[35] Herting B, Schulze S, Reichmann H, et al. A longitudinal study of olfactory fun-ction in patients with idiopathic Parkinson's disease[J]. Neurol, 2008, 255(3):367-370.
[36] Tunc S, Graf J, Tadic V, et al. A Population-Based study on combined markers for early parkinson's disease[J]. Movement Disorders, 2015, 30(4):531-537.
[37] 前三位作者缺失.皮肤样本或有助于帕金森病早期诊断[J].中华中医药刊,2016,34(6):1491-1491.
[38] 科技部.德国发明早期诊断帕金森方法[R].科技之光,2017,87.