参考文献/References:
[1] Mulder M,Lingsma HF,Dippel D.Letter by mulder et al regarding article,"2018 guidelines for the early management of patients with acute ischemic stroke:a guideline for healthcare professionals from the American heart association/American stroke association[J].Stroke,2019,50(7):e211.
[2] Beck H,Plate KH.Angiogenesis after cerebral ischemia[J].Acta Neuropathol,2009,117(5):481-496.
[3] Milner R,Campbell IL.The integrin family of cell adhesion molecules has multiple functions within the CNS[J].Neurosci Res,2002,69(3):286-291.
[4] Zhang L,Zhang ZG,Zhang C,et al.Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model[J].Stroke,2004,35(12):2890-2895.
[5] Mozaffarian D,Benjamin EJ,Go AS,et al.Heart disease and stroke statistics-2016 update a report from the American heart association[J].Circulation,2016,133(4):E38-E360.
[6] Khoshnam SE,Winlow W,Farzaneh MA,et al.Pathogenic mechanisms following ischemic stroke[J].Neurological Sciences,2017,38(7):1167-1186.
[7] Khatri R,Mckinney AM,Swenson BA.Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke[J].Neurology,2012,79(13, 1):S52-S57.
[8] Cheon SY,Kim EJ,Kim JM,et al.Cell type-specific mechanisms in the pathogenesis of ischemic stroke: the role of apoptosis signal-regulating kinase 1[J].Oxid Med Cell Longev,2018,2018:2596043.
[9] Rodrigo R,Fernandez-Gajardo R,Gutierrez RA,et al.Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities[J].CNS Neurol Disord Drug Targets,2013,12(5):698-714.
[10] Chen AQ,Fang Z,Chen XL,et al.Microglia-derived TNF-alpha mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke[J].Cell Death Dis,2019,10(7):487.
[11] Gj H.Stroke[J].Lancet,2017,389(10069):641-654.
[12] Taylor RA,Sansing LH.Microglial responses after ischemic stroke and intracerebral hemorrhage[J].Clin Dev Immunol,2013,2013:746068.
[13] 张婷,易黎.小胶质细胞在脑缺血中发挥双相作用[J].卒中与神经疾病,2016,23(6):471-475.
[14] Fan H,Zhang K,Shan LQ,et al.Reactive astrocytes undergo M1 microglia/macrohpages- induced necroptosis in spinal cord injury[J].Mol Neurodegener,2016,11:14.
[15] Gaire BP,Song MR,Choi JW.Sphingosine 1-phosphate receptor subtype 3(S1P(3))contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization[J].J Neuroinflammation,2018,15(1):284.
[16] De Marco R,Tolomelli A,Juaristi EA.Integrin ligands with alpha/ beta-Hybrid peptide structure: design, bioactivity, and conformational aspects[J].Med Res Rev,2016,36(3):389-424.
[17] Hynes RO.Integrins: bidirectional, allosteric signaling machines[J].Cell,2002,110(6):673-687.
[18] Adorno-Cruz V,Liu H.Regulation and functions of integrin alpha2 in cell adhesion and disease[J].Genes Dis,2019,6(1):16-24.
[19] Mitroulis I,Alexaki VI,Kourtzelis IA,et al.Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease[J].Pharmacol Ther,2015,147:123-135.
[20] Lu ZW,Mathew S,Chen J,et al.Implications of the differing roles of the beta 1 and beta 3 transmembrane and cytosplasmic domains for integrin function[J].Elife,2016,5:e18633.
[21] Conroy KP,Kitto LJ,Henderson NC.Alpha v integrins: key regulators of tissue fibrosis[J].Cell Tissue Res,2016,365(3):511-519.
[22] Lowin T,Straub RH.Integrins and their ligands in rheumatoid arthritis[J].Arthritis Res Ther,2011,13(5):244.
[23] Turaga RC,Yin L,Yang JJ,et al.Rational design of a protein that binds integrin alpha(v)beta(3)outside the ligand binding site[J].Nat Commun,2016,7:11675.
[24] Jiao Y,Feng XE,Zhan YP,et al.Matrix metalloproteinase-2 promotes alpha v beta 3 integrin-mediated adhesion and migration of human melanoma cells by cleaving fibronectin[J].PLoS One,2012,7(7):e41591.
[25] Ma Y,Ai GH,Zhang CY,et al.Novel linear peptides with high affinity to alpha v beta 3 integrin for precise tumor identification[J].Theranostics,2017,7(6):1511-1523.
[26] 刘莉,丁丽君.靶向整合素α_vβ_3药物的研究进展[J].中国新药与临床杂志,2017,36(9):505-510.
[27] Hatley RJ,Macdonald SJ,Slack RJ,et al.An alpha v-RGD integrin inhibitor toolbox: drug discovery insight, challenges and opportunities[J].Angewandte Chemie-International Edition,2018,57(13):3298-3321.
[28] Morshed A,Abbas AB,Hu J,et al.Shedding new light on the role of ανβ3 and α5β1 integrins in rheumatoid arthritis[J].Molecules,2019,24(8):1537.
[29] Abumiya T,Lucero J,Heo JH,et al.Activated microvessels express vascular endothelial growth factor and integrin alpha(V)beta(3)during focal cerebral ischemia[J].Journal of Cerebral Blood Flow and Metabolism,1999,19(9):1038-1050.
[30] Fang T,Zhou D,Lu L,et al.LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats[J].Brazilian Journal of Medical and Biological Research,2016,49(9):e5287.
[31] Kiessling JW,Cines DB,Higazi AA,et al.Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia[J].Am J Physiol Heart Circ Physiol,2009,296(3):H862-H867.
[32] Shimamura N,Matchett G,Solaroglu IA,et al.Inhibition of integrin alpha vP3 reduces blood-brain barrier breakdown in focal ischernia in rats[J].J Neurosci Res,2006,84(8):1837-1847.
[33] Sajib S,Zahra FT,Lionakis MS,et al.Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions[J].Angiogenesis,2018,21(1):1-14.
[34] Avraamides CJ,Garmy-Susini B,Varner JA.Integrins in angiogenesis and lymphangiogenesis[J].Nat Rev Cancer,2008,8(8):604-617.
[35] Brooks PC,Clark RA,Cheresh DA.Requirement of vascular integrin alpha v beta 3 for angiogenesis[J].Science,1994,264(5158):569-571.
[36] Shimamura N,Matchett G,Yatsushige H,et al.Inhibition of integrin alphavbeta3 ameliorates focal cerebral ischemic damage in the rat middle cerebral artery occlusion model[J].Stroke,2006,37(7):1902-1909.
[37] 陆林清,方婷,周达,童晓欣,等.整合素αvβ3抑制剂西仑吉肽在大鼠急性脑缺血中的作用机制[J].中华医学杂志, 2016,96(7):559-564.
[38] Stupp R,Hegi ME,Gorlia T,et al.Van den bent MJ,hicking C,markivskyy a,picard M,weller M.cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter(CENTRIC EORTC 26071-22072 study):a multicentre,randomised,open-label,phase 3 trial[J].Lancet Oncol,2014,15(10):1100-1108.
[39] Jia J,Li C,Zhang T,et al.Attenuates LPS-induced inflammation in BV2 microglia[J].Cell Mol Neurobiol,2019,39(8):1125-1137.
[40] Xiao W,Wang Y,Lau EY,et al.The use of one-bead one-compound combinatorial library technology to discover high-affinity alphavbeta3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle[J].Mol Cancer Ther,2010,9(10):2714-2723.
[41] Jia JJ,Zhang T,Chi JS,et al.Neuroprotective effect of CeO2@PAA-LXW7 against H2O2-Induced cytotoxicity in NGF-Differentiated PC12 cells[J].Neurochem Res,2018,43(7):1439-1453.