[1]彭勃,库小维,饶立,等.选择运动功能缺损的脑梗死大鼠模型的制作[J].卒中与神经疾病杂志,2024,(01):28-31.[doi:10.3969/j.issn.1007-0478.2024.01.005]
 Peng Bo*,Ku Xiaowei,Rao Li,et al.Establishment of a rat model of cerebral infarction with selected motor function deficits[J].Stroke and Nervous Diseases,2024,(01):28-31.[doi:10.3969/j.issn.1007-0478.2024.01.005]
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选择运动功能缺损的脑梗死大鼠模型的制作()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
期数:
2024年01期
页码:
28-31
栏目:
论著
出版日期:
2024-02-20

文章信息/Info

Title:
Establishment of a rat model of cerebral infarction with selected motor function deficits
文章编号:
1007-0478(2024)01-0028-04
作者:
彭勃库小维饶立李涛
430060 武汉大学人民医院东院神经内科、医疗部(彭勃),神经内科\[李涛(通信作者)\],内分泌科(库小维), 老年病科(饶立)
Author(s):
Peng Bo* Ku Xiaowei Rao Li et al.
*Department of Neurology, Peoples Hospital of Wuhan University, Wuhan 430060
关键词:
光化学法孟加拉红行为学评价组织学评价
Keywords:
Photodynamic method Rose Bengal Behavioral evaluation Histological evaluation
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2024.01.005
文献标志码:
A
摘要:
目的 确立一种制作皮层梗死部位大小一致、梗死后症状大致一致的脑梗死大鼠模型方法。 方法 利用光化学法结合大鼠皮层运动功能区图谱制作运动功能缺损的脑梗死大鼠模型;采用行为学及组织学评价;评估不同照射时间组运动神经功能的缺损程度。 结果 利用运动皮层定位技术成功制作选择运动神经功能缺损的脑梗死大鼠模型,这个模型的梗死灶的部位、大小相近,面积不超过4 mm×4 mm,而且有一侧前后肢运动功能缺失;发现照射40 min有血管再通现象,而照射60 min无血管再通现象,梗死灶的部位更恒定,大鼠运动功能缺损症状更明显。 结论 采用光化学法结合大鼠皮层运动功能区图谱成功制作运动功能缺损的脑梗死大鼠模型。
Abstract:
Objective〖WTBZ〗 To establish a method for creating a consistent rat model of cortical infarction in terms of the size of the infarcted area and the resulting symptoms. 〖WTHZ〗Methods 〖WTBZ〗 We used the photodynamic method combined with a rat cortical motor functional area map to create a rat model of motor functional deficit due to cerebral infarction. Through behavioral and histological evaluations, we assessed the degree of motor nerve function impairment in different irradiation time groups. 〖WTHZ〗Results 〖WTBZ〗 Using motor cortex localization techniques, we successfully created a rat model of cerebral infarction with selective motor nerve function deficits. The infarcted area in this model was similar in location and size, not exceeding 4 mm×4 mm, and resulted in impaired movement of the limbs on one side. We found that a 40-minute irradiation resulted in reperfusion of the blood vessels, whereas a 60-minute irradiation did not, leading to a more consistent infarcted area and more pronounced symptoms of motor functional deficit in the rats. 〖WTHZ〗Conclusion 〖WTBZ〗 The rat model of cerebral infarction with motor function deficit was successfully made by photodynamic method combined with cortical motor functional area map.

参考文献/References:

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更新日期/Last Update: 2024-02-20