[1]甘泉,石明,方玉婷,等.血小板参数与血液透析相关性头痛[J].卒中与神经疾病杂志,2024,(01):58-62.[doi:10.3969/j.issn.1007-0478.2024.01.010]
　Gan Quan*,Shi Ming,Fang Yuting*,et al.The relationship between the mean platelet volume/platelet ratio and hemodialysis-related headache[J].Stroke and Nervous Diseases,2024,(01):58-62.[doi:10.3969/j.issn.1007-0478.2024.01.010]
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血小板参数与血液透析相关性头痛()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
期数:
2024年01期
页码:
58-62
栏目:
论著
出版日期:
2024-02-20

文章信息/Info

Title:
The relationship between the mean platelet volume/platelet ratio and hemodialysis-related headache
文章编号:
1007-0478(2024)01-0058-05
作者:
甘泉; 石明; 方玉婷; 肖哲曼
430060 武汉大学人民医院神经内科\[甘泉 方玉婷 肖哲曼（通信作者）\]，透析中心（石明）
Author(s):
Gan Quan*;  Shi Ming;  Fang Yuting*;  et al.
Department Of Neurology, Renmin Hospital Of Wuhan University, Wuhan 430060
关键词:
血液透析相关性头痛; 平均血小板体积/血小板比值; 危险因素; 严重程度; 生活质量
Keywords:
Hemodialysis-related headache Mean platelet volume/platelet ratio Risk factor Severity Quality of life
分类号:
R741.041
DOI:
10.3969/j.issn.1007-0478.2024.01.010
文献标志码:
A
摘要:
目的 探讨血小板参数及中性粒细胞与淋巴细胞比值(Neutrophil to lymphocyte ratio，NLR)与血液透析相关性头痛（Hemodialysis-related headache，HRH）的关系。 方法 选取2022年10月-2022年12月在武汉大学人民医院接受血液透析治疗的127例患者，根据国际头痛第3版分类诊断标准分为HRH组（n=55）和对照（comparative control,CC，n=72）组；比较2组基线资料；视觉模拟评分（Visual analogue score，VAS）、头痛影响测试（Headache impact test，HIT-6）、抑郁自评量表（Self-rating depression scale，SDS）和焦虑自评量表（Self-rating anxiety scale，SAS）分别用来评估HRH的严重程度、头痛患者的生活质量以及抑郁焦虑程度。 结果 与CC组比较，HRH组血小板计数（Platelet counts，PLT）、血小板比积（Platelet hematocrit，PCT）较低，平均血小板体积（Mean platelet volume，MPV）、血小板体积分布密度（Platelet distribution width，PDW）、大血小板比率（Platelet large cell ratio，P-LCR）以及MPV/PLT较高（P＜0.05)；多变量Logistic回归分析显示MPV,PDW,PCT以及P-LCR是HRH的危险因素（P＜0.05)；受试者工作特性曲线（Receiver operating characteristic curve，ROC）显示MPV/PLT诊断HRH的灵敏度和特异性最高；HRH患者的MPV/PLT水平与VAS和HIT-6评分呈正相关(r≥0.308，P＜0.05)。 结论 PLT，PCT，MPV以及MPV/PLT是HRH的独立危险因素，MPV/PLT水平与HRH的严重程度和生活质量呈正相关。
Abstract:
Objective〖WTBZ〗 To investigate the relationship between platelet parameters, the neutrophil-to-lymphocyte ratio (NLR) and hemodialysis-related headache (HRH). 〖WTHZ〗Methods 〖WTBZ〗 A total of 127 patients receiving hemodialysis at the Renmin Hospital of Wuhan University from October to December 2022 were included. They were divided into a hemodialysis-related headache group (HRH group, n=55) and a comparative control group (CC group, n=72) based on the criteria of the 3rd edition of the International Classification of Headache Disorders (ICHD-3). Compared and analyzed the baseline data of the two groups. The visual analog scale (VAS), headache impact test (HIT-6), self-rating depression scale (SDS), and self-rating anxiety scale (SAS) were used to evaluate the severity, the quality of life, and the degree of depression and anxiety of the HRH patients. 〖WTHZ〗Results 〖WTBZ〗 Compared to the CC group, the HRH group had lower platelet count (PLT) and platelet percentage (PCT), but higher average platelet volume (MPV), platelet volume distribution width (PDW), and large platelet ratio (P-LCR) (P<0.05). Multivariable Logistic regression analysis showed that MPV, PDW, PCT, and P-LCR were risk factors for HRH (P<0.05). The ROC curve showed that MPV/PLT had the highest sensitivity and specificity for diagnosing HDH. The MPV/PLT level of HDH patients was positively related to the VAS and HIT-6 scores (P<0.05). 〖WTHZ〗Conclusion 〖WTBZ〗 PLT, PCT, MPV, and MPV/PLT were independent risk factors for HRH. The level of MPV/PLT was positively related to the severity and the quality of life of HRH.

参考文献/References:

[1] Gozubatik-Celik G,Uluduz D,Goksan B,et al.Hemodialysis-related headache and how to prevent it[J].Eur J Neurol,2019,26(1):100-105.
[2] The International Classification of Headache Disorders, 3rd edition (beta version)[J]. Cephalalgia:an International Journal of Headache,2013,33(9):629-808. 
[3] Yang Y,Meng F,Zhu H,et al.The applicability research of the diagnostic criteria for 10.2 heamodialysis-related headache in the international classification of headache disorders-3rd edition[J].The Journal of Headache and Pain,2023,24(1):19. 
[4] Kalantar-Zadeh K,Lockwood MB,Rhee CM,et al.Patient-centred approaches for the management of unpleasant symptoms in kidney disease[J].Nat Rev Nephrol,2022,18(3):185-198.
[5] Sousa ME,Carrilho AF.Sampaio Rocha-Filho P:dialysis headache:a narrative review[J].Headache,2017,57(1):161-164.
[6] Gksan B,Karaali-Savrun F,Ertan S,et al.Haemodialysis-related headache[J]. Cephalalgia:an International Journal of Headache,2004,24(4):284-287.
[7] Goksel BK,Torun D,Karaca S,et al.Is low blood Magnesium level associated with hemodialysis headache?[J].Headache,2006,46(1):40-45.
[8] Alessandri M,Massanti L,Geppetti P,et al.Plasma changes of calcitonin gene-related peptide and substance P in patients with dialysis headache[J].Cephalalgia,2006,26(11):1287-1293.
[9] Ramachandran R.Neurogenic inflammation and its role in migraine[J].Semin Immunopathol,2018,40(3):301-314.
[10]Lee SH,Kim JH,Kwon YS,et al.Role of peripheral inflammatory markers in patients with acute headache attack to differentiate between migraine and non-migraine headache[J].J Clin Med,2022,11(21):6538.
[11]zdemir HH,Dnder A.Evaluation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein in tension-type headache patients[J].J Neurosci Rural Pract,2021,12(3):566-570.
[12]Daugirdas JT,Bernardo AA.Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia[J].Kidney Int,2012,82(2):147-157.
[13]Borgdorff P,Tangelder GJ.Migraine: possible role of shear-induced platelet aggregation with serotonin release[J].Headache,2012,52(8):1298-1318.
[14]左晨羲,王孟坤.平均血小板体积/血小板比值对急性脑梗死严重程度及预后的评估价值[J].中风与神经疾病杂志,2022,39(4):324-327.
[15]〖JP2〗Sansanayudh N,Anothaisintawee T,Muntham D,et al.Mean platelet volume and coronary artery disease: a systematic review and meta-analysis[J].Int J Cardiol,2014,175(3):433-440. 
[16]Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition [J].Cephalalgia :an International Journal of Headache,2018,38(1):1-211. 
[17]Luo DG,Luo YM,Zou YH,et al.Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis[J].Lipids Health Dis,2021,20(1):159.
[18]Ling T,Cccjckyjy Y.Validation of the dialysis dementia risk score:a retrospective.Population-based,nested case-control study[J].Eur J Neurol,2022,29(1):59-68.
[19]Boonpheng B,Thongprayoon C,Cheungpasitporn W.The comparison of risk of stroke in patients with peritoneal dialysis and hemodialysis: a systematic review and meta-analysis[J].J Evid Based Med,2018,11(3):158-168.
[20]Kauffmann M,Bobot M,Robert T,et al.Disease activity and adverse events in patients with ANCA-associated vasculitides undergoing long-term dialysis[J].Clin J Am Soc Nephrol,2021,16(11):1665-1675.
[21]杨怡尧.苏州地区透析性头痛临床特征及影响因素分析.硕士[Z],2019.
[22]Lano G,Sallée M,Pelletier M,et al.Mean platelet volume predicts vascular access events in hemodialysis patients[J].J Clin Med,2019,8(5):608. 
[23]Stegner D,vanEeuwijk JMM,Angay O,et al.Thrombopoiesis is spatially regulated by the bone marrow vasculature[J].Nat Commun,2017,8(1):127.
[24]肖明锋,刘基铎,吴培洁,等.血小板参数在血小板减少性疾病中的应用[J].国际检验医学杂志,2013,34(4):418-420.
[25]Sari O,Bashir AM. Early change in platelet count and MPV levels of patients who received hemodialysis for the first time:mogadishu somalia experience[Z], 2022: 1503227.
[26]Eicher JD,Chami N,Kacprowski T,et al.Platelet-related variants identified by exomechip meta-analysis in 157,293 individuals[J].Am J Hum Genet,2016,99(1):40-55.
[27]Harriott AM,Karakaya F,Ayata C.Headache after ischemic stroke:a systematic review and meta-analysis[J].Neurology,2020,94(1):e75-e86.
[28]高洁,徐格林.卒中与头痛[J].实用老年医学,2015,29(10):799-802.
[29]Oliveira FAA,Sampaio Rocha-Filho PA.Headaches attributed to ischemic stroke and transient ischemic attack[J].Headache,2019,59(3):469-476.
[30]梁春婷,杜晓刚.维持性血液透析患者贫血相关指标与心脑血管事件的相关性[J].中国中西医结合肾病杂志,2021,22(4):364-366.

更新日期/Last Update: 2024-02-20