[1]贾培飞,张金洪,高秉勋.进行性核上性麻痹的临床特征分析[J].卒中与神经疾病杂志,2024,(01):81-86.[doi:10.3969/j.issn.1007-0478.2024.01.014]
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进行性核上性麻痹的临床特征分析()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
期数:
2024年01期
页码:
81-86
栏目:
论著
出版日期:
2024-02-20

文章信息/Info

文章编号:
1007-0478(2024)01-0081-06
作者:
贾培飞; 张金洪; 高秉勋
014030 内蒙古自治区包头市内蒙古科技大学包头医学院第二附属医院神经内科\[贾培飞 高秉勋（通信作者）\]；河北省沧州市人民医院神经内科（张金洪）
关键词:
进行性核上性麻痹; 临床特征; 认知功能障碍
分类号:
R742
DOI:
10.3969/j.issn.1007-0478.2024.01.014
文献标志码:
A
摘要:
目的 分析进行性核上性麻痹(Progressive supranuclear palsy,PSP)的临床特征。 方法 对PSP患者的人口学及临床特点进行回顾性分析，收集2017年10月-2020年10月全国PSP研究联盟中的11个中心的门诊及住院PSP患者302例，对研究对象的一般资料、临床特征及相应量表进行归纳分析。 结果 PSP亚型中PSP理查森型（PSP-Richardsons syndrome，RS）型最多，共178例，占比58.9%；其次为PSP帕金森综合征型（PSP-Parkinsonism，P）型92例，占比30.4%；其余依次为PSP纯少动伴冻结步态型（PSP-pure akiesia with gait freezing，PGF）型16例(5.2%)、PSP变异型额颞叶痴呆（PSP-behavioral variant frontotemproal dementia，F）型10例(3.3%)、PSP皮质基底节综合征型（PSP-corticobasal syndrome，CBS）型6例(2.0%)。性别年龄分层中男182例，女140例；其中60~70岁为发病高峰，共148例，占比49.3%。首发症状主要以姿势不稳和行动迟缓为主，分别为111、97例，占比分别为36.8%、32.1%；PSP患者中70.3%出现上、下视障碍，尤以PSP-RS型居多，占比80.5%。113例完成整体认知功能评价，其中痴呆51例，占比44.8%；轻度认知功能障碍35例，占比31.1%。 结论 PSP患者中PSP-RS型占比最多，男女比例相当，60~70岁为发病高峰，首发症状主要以步态不稳、运动迟缓为主，垂直性核上性麻痹与认知功能障碍是PSP的核心特征。

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更新日期/Last Update: 2024-02-20